DiseaseID 6208
肝母细胞瘤
disease
MEDLINEPLUS_20151021:<p>Your liver is the largest organ inside your body. It helps your body digest food, store energy, and remove poisons. Primary liver cancer starts in the liver. Metastatic liver cancer starts somewhe
Relationship Network
Interactive first-hop connections across herbs, ingredients, formulas, targets, diseases, symptoms, syndromes, evidence, and monographs.
Click a node to open it in a new tab
Disease: 1Herb: 12Symptom: 12Target: 23Links: 48
Arranging relationship network...
Record Fields
Scalar fields from the final disease record.
- Disease Id
- 6208
- Core Entity Id
- 62827
- Source Entity Count
- 1
- Preferred Name
- Hepatoblastoma
- Name Cn
- 肝母细胞瘤
- Name Pinyin
- Gan Mu Xi Bao Liu
- Name En
- Hepatoblastoma
- Name Latin
- Bilingual Status
- complete
- Disease Type
- disease
- Umls Disease Type
- Neoplastic Process
- Disgenet Type
- disease
- Mesh Class
- Digestive System Diseases; NeoplasmsNeoplasmsNervous System Diseases; Neoplasms
- Do Class
- disease of anatomical entity; disease of cellular proliferation
- Hpo Class
- Abnormality of the nervous system; Abnormality of the integument; NeoplasmNeoplasm; Abnormality of the digestive systemNeoplasm; Abnormality of the nervous system
- Mesh Class Name
- Digestive System Diseases; NeoplasmsNeoplasmsNeoplasms; Nervous System Diseases
- Hpo Class Name
- Abnormality of the digestive system; NeoplasmAbnormality of the integument; Abnormality of the nervous system; Neoplasm
- Do Class Name
- disease of anatomical entity; disease of cellular proliferation
- Disease Definition
- MEDLINEPLUS_20151021:<p>Your liver is the largest organ inside your body. It helps your body digest food, store energy, and remove poisons. Primary liver cancer starts in the liver. Metastatic liver cancer starts somewhere else and spreads to your liver. </p> <p>Risk factors for primary liver cancer include </p> <ul> <li>Having <a href='https://www.nlm.nih.gov/medlineplus/hepatitisb.html'>hepatitis B</a> or <a href='https://www.nlm.nih.gov/medlineplus/hepatitisc.html'>C</a></li> <li>Heavy alcohol use</li> <li>Having <a href='https://www.nlm.nih.gov/medlineplus/cirrhosis.html'>cirrhosis</a>, or scarring of the liver</li> <li>Having <a href='https://www.nlm.nih.gov/medlineplus/hemochromatosis.html'>hemochromatosis</a>, an iron storage disease</li> <li>Obesity and diabetes</li> </ul> <p>Symptoms can include a lump or pain on the right side of your abdomen and yellowing of the skin. However, you may not have symptoms until the cancer is advanced. This makes it harder to treat. Doctors use tests that examine the liver and the blood to diagnose liver cancer. Treatment options include surgery, radiation, chemotherapy, or <a href='https://www.nlm.nih.gov/medlineplus/livertransplantation.html'>liver transplantation</a>. </p> <p >NIH: National Cancer Institute</p>
- Version
- v1
- Suppressed
- No
Names
Preferred names, aliases, and source labels retained in the final schema.
Name
Hepatoblastoma
Role
preferred
Name
Hepatocellular Carcinoma
Role
preferred
Name
Liver Carcinoma
Role
preferred
Name
Liver Neoplasms
Role
preferred
Name
Malignant Neoplasm Of Liver
Role
preferred
Name
Choroid Plexus Carcinoma
Role
preferred
Name
Choroid Plexus Papilloma
Role
preferred
Name
Hepatoblastoma Caused By Somatic Mutation
Role
preferred
Name
Primary Malignant Liver Neoplasm
Role
preferred
Name
Resectable Malignant Liver Neoplasm
Role
preferred
Name
CANCER, HEPATOCELLULAR
Role
alias
Name
Cancer of Liver
Role
alias
Name
Carcinoma, Hepatocellular
Role
alias
Name
HCC
Role
alias
Name
HEPATOMA
Role
alias
Name
LCC
Role
alias
Name
LIVER CANCER
Role
alias
Name
LIVER CELL CARCINOMA
Role
alias
Name
Liver Tumor
Role
alias
Name
Liver, Unspecified
Role
alias
Name
Malignant Neoplasm of Liver, Unspecified
Role
alias
Name
Neoplasm of The Liver
Role
alias
Name
Neoplasms, Liver
Role
alias
Name
Papilloma of Choroid Plexus
Role
alias
Name
Papilloma, Choroid Plexus
Role
alias
Cross References
Trusted external identifiers retained for this final record.
Hpo
HP:0001402HP:0002884HP:0002896HP:0030392HP:0200022
Herb
HBDIS001772HBDIS001842HBDIS004299HBDIS004369HBDIS008291HBDIS009306HBDIS011962HBDIS018998HBDIS019427
Me Sh
D006528D008113D018197D020288
Omim
114550260500
Umls
C0023903C0206624C0345904C2239176C2676033
Icd10
C22.0C22.2C22.9
Sym Map
SMDE01307SMDE07086SMDE07090SMDE09386SMDE10481SMDE10490SMDE10689
Do Class
DOID:14566DOID:7
Dis Ge Net
C0023903C0024620C0205770C0206624C0345904C0431109C0854795C2239176C2676033
Umls Sty
T191
Hpo Class
HP:0000707HP:0001574HP:0002664HP:0025031
Me Sh Class
C04C06C10
Etcm Disease
Hepatocellular Carcinoma
Tcmbank Disease
112361395154961689517808207592200522162290623665307388118987
Itcmdb Generated
ITX-DISEASE-2F9DF5A2A795ITX-DISEASE-3F9FD1998A81ITX-DISEASE-635B0D1E2B8BITX-DISEASE-7A1EA1348AD2ITX-DISEASE-AB2B76C10B0DITX-DISEASE-CAE5413EE03EITX-DISEASE-D679B74D9ABC
Attributes
Merged source attributes and domain-specific metadata.
Version
v1v2
Suppress
0
Page Title
Disease Hepatocellular Carcinoma Details page
Do Class Name
disease of anatomical entity; disease of cellular proliferation
Disease Type
diseasegroup
Hpo Class Name
Abnormality of the digestive system; NeoplasmAbnormality of the integument; Abnormality of the nervous system; Neoplasm
Do Disease Class
disease of anatomical entity; disease of cellular proliferation
Hpo Disease Class
Abnormality of the nervous system; Abnormality of the integument; NeoplasmNeoplasm; Abnormality of the digestive systemNeoplasm; Abnormality of the nervous system
Umls Disease Type
Neoplastic Process
Basic Information
Disease Name
Hepatocellular Carcinoma
Global Category
Cancer diseases;Genetic diseases;Rare diseases
Anatomical Category
Endocrine diseases;Gastrointestinal Diseases;Liver diseases
Disease Definition
MEDLINEPLUS_20151021:<p>Your liver is the largest organ inside your body. It helps your body digest food, store energy, and remove poisons. Primary liver cancer starts in the liver. Metastatic liver cancer starts somewhere else and spreads to your liver. </p> <p>Risk factors for primary liver cancer include </p> <ul> <li>Having <a href='https://www.nlm.nih.gov/medlineplus/hepatitisb.html'>hepatitis B</a> or <a href='https://www.nlm.nih.gov/medlineplus/hepatitisc.html'>C</a></li> <li>Heavy alcohol use</li> <li>Having <a href='https://www.nlm.nih.gov/medlineplus/cirrhosis.html'>cirrhosis</a>, or scarring of the liver</li> <li>Having <a href='https://www.nlm.nih.gov/medlineplus/hemochromatosis.html'>hemochromatosis</a>, an iron storage disease</li> <li>Obesity and diabetes</li> </ul> <p>Symptoms can include a lump or pain on the right side of your abdomen and yellowing of the skin. However, you may not have symptoms until the cancer is advanced. This makes it harder to treat. Doctors use tests that examine the liver and the blood to diagnose liver cancer. Treatment options include surgery, radiation, chemotherapy, or <a href='https://www.nlm.nih.gov/medlineplus/livertransplantation.html'>liver transplantation</a>. </p> <p >NIH: National Cancer Institute</p>MSH2017_2016_08_12:Tumors or cancer of the LIVER.|HPO2016_07_04:A tumor (abnormal growth of tissue) of the liver. [HPO:probinson]|CSP2006:new abnormal liver tissue that grows by excessive cellular division and proliferation more rapidly than normal and continues to grow after the stimuli that initiated the new growth cease; do not confuse with intrahepatic neoplasm as that may refer to bile duct neoplasm (BILIARY TRACT NEOPLASM).NCI2016_CDISC_1602D:A benign neoplasm of the choroid plexus of the central nervous system.|NCI2016_02D:A benign, slow growing tumor which may cause symptoms by blocking cerebrospinal fluid pathways. It is characterized by the presence of delicate fibrovascular connective tissue fronds covered by a single layer of epithelial cells. Mitotic activity is extremely low. Surgical resection is usually curative. (Adapted from WHO)|MSH2017_2016_08_12:A usually benign neoplasm that arises from the cuboidal epithelium of the choroid plexus and takes the form of an enlarged CHOROID PLEXUS, which may be associated with oversecretion of CSF. The tumor usually presents in the first decade of life with signs of increased intracranial pressure including HEADACHES; ATAXIA; DIPLOPIA; and alterations of mental status. In children it is most common in the lateral ventricles and in adults it tends to arise in the fourth ventricle. Malignant transformation to choroid plexus carcinomas may rarely occur. (Adams et al., Principles of Neurology, 6th ed, p667; DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, p2072)|HPO2016_07_04:Choroid plexus papilloma is a histologically benign neoplasm located in the ventricular system of the choroid plexus. [HPO:skoehler]NCI2016_CDISC_1602D:A malignant neoplasm arising from the choroid plexus of the brain.|NCI2016_02D:A malignant neoplasm arising from the choroid plexus. It shows anaplastic features and usually invades neighboring brain structures. Cerebrospinal fluid metastases are frequent. (Adapted from WHO)|HPO2016_07_04:Intraventricular papillary neoplasm derived from choroid plexus epithelium. Plexus tumors are most common in the lateral and fourth ventricles; while 80% of lateral ventricle tumors present in children, fourth ventricle tumors are evenly distributed in all age groups. Clinically, choroid plexus tumors tend to cause hydrocephalus and increased intracranial pressure. Histologically, choroid plexus papillomas correspond to WHO grade I, choroid plexus carcinomas to WHO grade III. [HPO:probinson, pmid:11135453]NCI2016_NCI-GLOSS_1602D:A type of adenocarcinoma and the most common type of liver tumor.|NCI2016_CDISC_1602D:A malignant neoplasm arising from hepatocytes.|NCI2016_02D:A malignant tumor that arises from hepatocytes. Hepatocellular carcinoma is relatively rare in the United States but very common in all African countries south of the Sahara and in Southeast Asia. Most cases are seen in patients over the age of 50 years, but this tumor can also occur in younger individuals and even in children. Hepatocellular carcinoma is more common in males than females and is associated with hepatitis B, hepatitis C, chronic alcohol abuse and cirrhosis. Serum elevation of alpha-fetoprotein occurs in a large percentage of patients with hepatocellular carcinoma. Grossly, hepatocellular carcinoma may present as a single mass, as multiple nodules, or as diffuse liver involvement. Microscopically, there is a wide range of differentiation from tumor to tumor (well differentiated to poorly differentiated tumors). Hepatocellular carcinomas quickly metastasize to regional lymph nodes and lung. The overall median survival of untreated liver cell carcinoma is about 4 months. The most effective treatment of hepatocellular carcinoma is complete resection of the tumor. Lately, an increasing number of tumors have been treated with liver transplantation.|MSH2017_2016_08_12:A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.|HPO2016_07_04:A kind of neoplasm of the liver that originates in hepatocytes and presents macroscopically as a soft and hemorrhagic tan mass in the liver. [HPO:probinson]|CSP2006:primary malignant neoplasm of epithelial liver cells; it ranges from a well-differentiated tumor with epithelial cells indistinguishable from normal hepatocytes to a poorly differentiated neoplasm; the cells may be uniform or markedly pleomorphic, or form giant cells; associations exist with chronic hepatitis B virus infection, some types of cirrhosis, and hepatitis C virus infection.NCI2016_NICHD_1602D:A malignant neoplasm of embryonal origin arising within the liver|NCI2016_NCI-GLOSS_1602D:A type of liver tumor that occurs in infants and children.|NCI2016_CDISC_1602D:A malignant liver neoplasm composed of immature hepatocytic elements.|NCI2016_02D:A malignant liver neoplasm that occurs almost exclusively in infants, although isolated cases in older children and adults have been reported. Grossly, hepatoblastoma is solid, well circumscribed, and more often solitary than multiple. Microscopically, most of the tumors are composed exclusively of immature hepatocytic elements. About a fourth of hepatoblastomas contain a stromal component that may be undifferentiated or develop into bone or cartilage. The treatment of choice for hepatoblastoma is surgical excision with adjuvant therapy. Liver transplantation is being increasingly used as well.|MSH2017_2016_08_12:A malignant neoplasm occurring in young children, primarily in the liver, composed of tissue resembling embryonal or fetal hepatic epithelium, or mixed epithelial and mesenchymal tissues. (Stedman, 25th ed)|HPO2016_07_04:A kind of neoplasm of the liver that originates from immature liver precursor cells and macroscopically is composed of tissue resembling fetal or mature liver cells or bile ducts. [eMedicine:986802, HPO:probinson]|CSP2006:malignant liver neoplasm occurring in children and composed of tissue resembling fetal or mature liver cells or bile ducts.
Me Sh Disease Class
Digestive System Diseases; NeoplasmsNeoplasmsNervous System Diseases; Neoplasms
Dis Ge Net Disease Type
diseasegroup
Disease Class Name Me Sh
Digestive System Diseases; NeoplasmsNeoplasmsNeoplasms; Nervous System Diseases
Umls Semantic Type Name
Neoplastic Process