DiseaseID 5498
Pick综合征
disease
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive muscular paralysis reflecting degeneration of motor neurons in the primary motor cortex, corticospinal t
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Disease: 1Experiment: 10Formula: 15Herb: 12Symptom: 12Target: 24Links: 73
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Record Fields
Scalar fields from the final disease record.
- Disease Id
- 5498
- Core Entity Id
- 62010
- Source Entity Count
- 1
- Preferred Name
- Pick Complex
- Name Cn
- Pick综合征
- Name Pinyin
- Pick Zong He Zheng
- Name En
- Pick Complex
- Name Latin
- Bilingual Status
- complete
- Disease Type
- disease
- Umls Disease Type
- Disease or Syndrome
- Disgenet Type
- disease
- Mesh Class
- Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System DiseasesMental Disorders; Nervous System DiseasesMental Disorders; Nervous System Diseases; Pathological Conditions, Signs and SymptomsNervous System DiseasesNervous System Diseases; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Respiratory Tract DiseasesNervous System Diseases; Mental Disorders; Nutritional and Metabolic DiseasesNervous System Diseases; Nutritional and Metabolic Diseases
- Do Class
- disease of anatomical entitydisease of anatomical entity; genetic diseasedisease of mental health; disease of anatomical entitydisease of mental health; disease of anatomical entity; genetic disease
- Hpo Class
- Abnormality of the nervous system
- Mesh Class Name
- Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System DiseasesCongenital, Hereditary, and Neonatal Diseases and Abnormalities; Respiratory Tract Diseases; Nervous System DiseasesNervous System DiseasesNervous System Diseases; Mental DisordersNutritional and Metabolic Diseases; Nervous System DiseasesNutritional and Metabolic Diseases; Nervous System Diseases; Mental DisordersPathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders
- Hpo Class Name
- Abnormality of the nervous system
- Do Class Name
- disease of anatomical entitydisease of anatomical entity; disease of mental healthgenetic disease; disease of anatomical entitygenetic disease; disease of anatomical entity; disease of mental health
- Disease Definition
- Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive muscular paralysis reflecting degeneration of motor neurons in the primary motor cortex, corticospinal t
- Version
- v1
- Suppressed
- No
Names
Preferred names, aliases, and source labels retained in the final schema.
Name
Pick Complex
Role
preferred
Name
Amyotrophic Lateral Sclerosis 1
Role
preferred
Name
Amyotrophic Lateral Sclerosis 11
Role
preferred
Name
Amyotrophic Lateral Sclerosis 12
Role
preferred
Name
Amyotrophic Lateral Sclerosis 15 With Or Without Frontotemporal Dementia
Role
preferred
Name
Amyotrophic Lateral Sclerosis 18
Role
preferred
Name
Amyotrophic Lateral Sclerosis 19
Role
preferred
Name
Amyotrophic Lateral Sclerosis 20
Role
preferred
Name
Amyotrophic Lateral Sclerosis 4, Juvenile
Role
preferred
Name
Amyotrophic Lateral Sclerosis, Sporadic
Role
preferred
Name
Frontotemporal Dementia
Role
preferred
Name
Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 3
Role
preferred
Name
Frontotemporal Lobar Degeneration With Tdp43 Inclusions, Grn-Related
Role
preferred
Name
Motor Neuron Disease
Role
preferred
Name
Pallidopontonigral Degeneration
Role
preferred
Name
Pick Disease Of Brain
Role
preferred
Name
Primary Progressive Aphasia (Disorder)
Role
preferred
Name
AMYOTROPHIC LATERAL SCLEROSIS 1, AUTOSOMAL RECESSIVE
Role
preferred
Name
AMYOTROPHIC LATERAL SCLEROSIS 15, WITH OR WITHOUT FRONTOTEMPORAL DEMENTIA
Role
preferred
Name
AMYOTROPHIC LATERAL SCLEROSIS 2, JUVENILE (disorder)
Role
preferred
Name
AMYOTROPHIC LATERAL SCLEROSIS 6 (disorder)
Role
preferred
Name
AMYOTROPHIC LATERAL SCLEROSIS 8 (disorder)
Role
preferred
Name
Amyotrophic Lateral Sclerosis
Role
preferred
Name
Amyotrophic Lateral Sclerosis 5
Role
preferred
Name
Amyotrophic Lateral Sclerosis With Dementia
Role
preferred
Name
Amyotrophic Lateral Sclerosis, Familial
Role
preferred
Name
Amyotrophic Lateral Sclerosis, Guam Form
Role
preferred
Name
Anterior Horn Cell Disease
Role
preferred
Name
Atrophy, Muscular, Spinobulbar
Role
preferred
Name
Behavioral Variant Of Frontotemporal Dementia
Role
preferred
Name
Familial Motor Neuron Disease
Role
preferred
Name
Juvenile Amyotrophic Lateral Sclerosis
Role
preferred
Name
Kennedy Disease
Role
preferred
Name
Lateral Sclerosis
Role
preferred
Name
Motor Neuron Disease, Lower
Role
preferred
Name
Motor Neuron Disease, Secondary
Role
preferred
Name
Motor Neuron Disease, Upper
Role
preferred
Name
Pick Disease of The Brain
Role
preferred
Name
Primary Lateral Sclerosis Juvenile
Role
preferred
Name
Primary Lateral Sclerosis, Adult, 1
Role
preferred
Name
Primary Lateral Sclerosis, Juvenile
Role
preferred
Name
Progressive Non-Fluent Aphasia
Role
preferred
Name
SPINAL MUSCULAR ATROPHY WITH RESPIRATORY DISTRESS 1
Role
preferred
Name
Semantic Dementia
Role
preferred
Name
Spastic Paralysis, Infantile-Onset Ascending
Role
preferred
Name
ALS1
Role
alias
Name
ALS11
Role
alias
Name
ALS12
Role
alias
Name
ALS15
Role
alias
Name
ALS18
Role
alias
Name
ALS19
Role
alias
Name
ALS20
Role
alias
Name
ALS4
Role
alias
Name
AMYOTROPHIC LATERAL SCLEROSIS 1, AUTOSOMAL DOMINANT
Role
alias
Name
AMYOTROPHIC LATERAL SCLEROSIS 1, FAMILIAL
Role
alias
Name
APHASIA, PRIMARY PROGRESSIVE
Role
alias
Name
Abnormal Anterior Horn Cell Morphology
Role
alias
Name
Abnormality of The Anterior Horn Cells
Role
alias
Name
Als6
Role
alias
Name
Amyotrophic Lateral Sclerosis 2, Juvenile
Role
alias
Name
Amyotrophic Lateral Sclerosis 5, Juvenile
Role
alias
Name
Amyotrophic Lateral Sclerosis 6 With Or Without Frontotemporal Dementia
Role
alias
Name
Amyotrophic Lateral Sclerosis 8
Role
alias
Name
Amyotrophic Lateral Sclerosis Type 1
Role
alias
Name
Amyotrophic Lateral Sclerosis Type 11
Role
alias
Name
Amyotrophic Lateral Sclerosis Type 12
Role
alias
Name
Amyotrophic Lateral Sclerosis Type 15
Role
alias
Name
Amyotrophic Lateral Sclerosis Type 18
Role
alias
Name
Amyotrophic Lateral Sclerosis Type 19
Role
alias
Name
Amyotrophic Lateral Sclerosis Type 2
Role
alias
Name
Amyotrophic Lateral Sclerosis Type 20
Role
alias
Name
Amyotrophic Lateral Sclerosis Type 4
Role
alias
Name
Amyotrophic Lateral Sclerosis Type 5
Role
alias
Name
Amyotrophic Lateral Sclerosis Type 6
Role
alias
Name
Amyotrophic Lateral Sclerosis Type 8
Role
alias
Name
Amyotrophic Lateral Sclerosis-Parkinsonism/Dementia Complex 1
Role
alias
Name
Anomaly of The Anterior Horn Cells
Role
alias
Name
DDPAC
Role
alias
Name
DEMENTIA WITH LOBAR ATROPHY AND NEURONAL CYTOPLASMIC INCLUSIONS
Role
alias
Name
DEMENTIA, FRONTOTEMPORAL, WITH PARKINSONISM
Role
alias
Name
DEMENTIA, HEREDITARY DYSPHASIC DISINHIBITION
Role
alias
Name
DISINHIBITION-DEMENTIA-PARKINSONISM-AMYOTROPHY COMPLEX
Role
alias
Name
Dementia, Frontotemporal
Role
alias
Name
Distal Spinal Muscular Atrophy 1
Role
alias
Name
FALS
Role
alias
Name
FLDEM
Role
alias
Name
FRONTOTEMPORAL DEMENTIA WITH PARKINSONISM
Role
alias
Name
FRONTOTEMPORAL DEMENTIA WITH TDP43 INCLUSIONS, GRN-RELATED
Role
alias
Name
FRONTOTEMPORAL DEMENTIA, UBIQUITIN-POSITIVE
Role
alias
Name
FRONTOTEMPORAL LOBAR DEGENERATION WITH TAU INCLUSIONS
Role
alias
Name
FRONTOTEMPORAL LOBAR DEGENERATION WITH UBIQUITIN-POSITIVE INCLUSIONS
Role
alias
Name
FRONTOTEMPORAL LOBE DEMENTIA
Role
alias
Name
FTD
Role
alias
Name
FTDALS3
Role
alias
Name
FTDP17
Role
alias
Name
FTDU
Role
alias
Name
FTLD WITH TAU INCLUSIONS
Role
alias
Name
FTLD-TDP, GRN-RELATED
Role
alias
Name
FTLDU
Role
alias
Name
Grn-Related Frontotemporal Lobar Degeneration With Tdp43 Inclusions
Role
alias
Name
Guam Disease
Role
alias
Name
HDDD
Role
alias
Name
LOBAR ATROPHY OF BRAIN
Role
alias
Name
Lou Gehrig'S Disease
Role
alias
Name
MSTD
Role
alias
Name
MULTIPLE SYSTEM TAUOPATHY WITH PRESENILE DEMENTIA
Role
alias
Name
Mesulam Syndrome
Role
alias
Name
NEURONOPATHY, DISTAL HEREDITARY MOTOR, WITH PYRAMIDAL FEATURES
Role
alias
Name
PPA
Role
alias
Name
PPND
Role
alias
Name
Pick'S Disease
Role
alias
Name
Spinal Muscular Atrophy, Distal, Autosomal Recessive, 1
Role
alias
Name
WILHELMSEN-LYNCH DISEASE
Role
alias
Name
WLD
Role
alias
Cross References
Trusted external identifiers retained for this final record.
Hpo
HP:0002145HP:0006802HP:0007354HP:0030219
Herb
HBDIS000134HBDIS003238HBDIS003874HBDIS003875HBDIS005051HBDIS006492HBDIS006493HBDIS007251HBDIS007659HBDIS007663HBDIS008663HBDIS009818HBDIS009877HBDIS010039HBDIS010040HBDIS011606HBDIS015604HBDIS015667HBDIS015951HBDIS016054HBDIS016950HBDIS017551HBDIS017719HBDIS017991HBDIS017993HBDIS018219HBDIS018703HBDIS019379HBDIS020660HBDIS021088HBDIS021407HBDIS021653HBDIS021777HBDIS022141HBDIS022142HBDIS022976HBDIS025732HBDIS027378HBDIS029032
Me Sh
D000690D016472D018888D020774D057180
Omim
105400105500172700205100205250300857600274602433604320606353607485608030608627612577613435614808615426615515616437
Umls
C0002736C0085084C0236642C0282513C0338451C0393547C0520716C0751706C0752353C1838313C1843792C1853396C1862939C1862941C1865409C2675491C2931441C3150692C3275459C3542025C3553719C3715155C3715156C4225326
Icd10
G12.2G12.20G31.0G31.01
Med Dra
1002954210068600
Sym Map
SMDE00420SMDE00788SMDE00990SMDE01018SMDE01315SMDE01402SMDE01573SMDE02051SMDE03051SMDE03077SMDE03344SMDE03361SMDE03438SMDE04062SMDE04176SMDE04342SMDE04577SMDE04869SMDE05054SMDE05807SMDE06158SMDE11094SMDE11826SMDE12160SMDE12455
Do Class
DOID:150DOID:630DOID:7
Dis Ge Net
C0002736C0085084C0154681C0154682C0236642C0270763C0270764C0282513C0338451C0338462C0393554C0520716C0521659C0543858C0543859C0752353C1837728C1838313C1842675C1843792C1853396C1858517C1859807C1862939C1862941C1865409C1865864C1968845C2675491C3150692C3275459C3468114C3542025C3553719C3715155C3715156C4011788C4225326C4551993
Orphanet
100070247604275864293168300605481803
Umls Sty
T047T048
Hpo Class
HP:0000707
Me Sh Class
C08C10C16C18C23F03
Etcm Disease
Amyotrophic Lateral Sclerosis 1Amyotrophic Lateral Sclerosis 11Amyotrophic Lateral Sclerosis 12Amyotrophic Lateral Sclerosis 15 with or Without Frontotemporal DementiaAmyotrophic Lateral Sclerosis 18Amyotrophic Lateral Sclerosis 19Amyotrophic Lateral Sclerosis 20Amyotrophic Lateral Sclerosis 4, JuvenileFrontotemporal DementiaFrontotemporal Dementia and/or Amyotrophic Lateral Sclerosis 3Frontotemporal Lobar Degeneration with Tdp43 Inclusions, Grn-RelatedJuvenile Amyotrophic Lateral Sclerosis
Tcmbank Disease
10269109511039131621422144511627616421164391650316779172881826418291198892115522117227292277323955241452443025573256582636826823269072693528369317573627431647884987647066528356864993919819
Itcmdb Generated
ITX-DISEASE-03B229DDA5FFITX-DISEASE-0D49DFE58742ITX-DISEASE-133EFA44FE29ITX-DISEASE-23CF5E845790ITX-DISEASE-3360A7688FD8ITX-DISEASE-5E396A99E4D8ITX-DISEASE-5E43FB638BA3ITX-DISEASE-7AFAADDCBB14ITX-DISEASE-7C651AD5F7F3ITX-DISEASE-848BE782EE13ITX-DISEASE-8A5393269C83ITX-DISEASE-93A0865371D6ITX-DISEASE-9D7D01E9147DITX-DISEASE-A9183DA5B9B3ITX-DISEASE-B4FCD5D959E7ITX-DISEASE-B56709DF3F5BITX-DISEASE-B693ED16707EITX-DISEASE-C6A1388AED69ITX-DISEASE-CEE609EB0137ITX-DISEASE-E03B3A52F29FITX-DISEASE-E292E567B822
Attributes
Merged source attributes and domain-specific metadata.
Version
v1v1,v2v2
Suppress
0
Page Title
Disease Amyotrophic Lateral Sclerosis 1 Details pageDisease Amyotrophic Lateral Sclerosis 11 Details pageDisease Amyotrophic Lateral Sclerosis 12 Details pageDisease Amyotrophic Lateral Sclerosis 15 with or Without Frontotemporal Dementia Details pageDisease Amyotrophic Lateral Sclerosis 18 Details pageDisease Amyotrophic Lateral Sclerosis 19 Details pageDisease Amyotrophic Lateral Sclerosis 20 Details pageDisease Amyotrophic Lateral Sclerosis 4, Juvenile Details pageDisease Frontotemporal Dementia Details pageDisease Frontotemporal Dementia and/or Amyotrophic Lateral Sclerosis 3 Details pageDisease Frontotemporal Lobar Degeneration with Tdp43 Inclusions, Grn-Related Details pageDisease Juvenile Amyotrophic Lateral Sclerosis Details page
Do Class Name
disease of anatomical entitydisease of anatomical entity; disease of mental healthgenetic disease; disease of anatomical entitygenetic disease; disease of anatomical entity; disease of mental health
Disease Type
disease
Hpo Class Name
Abnormality of the nervous system
Do Disease Class
disease of anatomical entitydisease of anatomical entity; genetic diseasedisease of mental health; disease of anatomical entitydisease of mental health; disease of anatomical entity; genetic disease
Hpo Disease Class
Abnormality of the nervous system
Umls Disease Type
Disease or SyndromeMental or Behavioral Dysfunction
Basic Information
Disease Name
Amyotrophic Lateral Sclerosis 1
Global Category
Genetic diseases;Metabolic diseases;Rare diseases
Anatomical Category
Mental diseases;Neuronal diseases;Respiratory diseases
Disease Name
Amyotrophic Lateral Sclerosis 11
Global Category
Genetic diseases;Metabolic diseases;Rare diseases
Anatomical Category
Mental diseases;Neuronal diseases;Respiratory diseases
Disease Name
Amyotrophic Lateral Sclerosis 12
Global Category
Genetic diseases;Metabolic diseases;Rare diseases
Anatomical Category
Mental diseases;Neuronal diseases;Respiratory diseases
Disease Name
Amyotrophic Lateral Sclerosis 15 with or Without Frontotemporal Dementia
Global Category
Genetic diseases;Rare diseases
Anatomical Category
Mental diseases;Neuronal diseases
Disease Name
Amyotrophic Lateral Sclerosis 18
Global Category
Genetic diseases;Metabolic diseases;Rare diseases
Anatomical Category
Mental diseases;Neuronal diseases;Respiratory diseases
Disease Name
Amyotrophic Lateral Sclerosis 19
Global Category
Genetic diseases;Metabolic diseases;Rare diseases
Anatomical Category
Mental diseases;Neuronal diseases;Respiratory diseases
Disease Name
Amyotrophic Lateral Sclerosis 20
Global Category
Genetic diseases;Metabolic diseases;Rare diseases
Anatomical Category
Mental diseases;Neuronal diseases;Respiratory diseases
Disease Name
Amyotrophic Lateral Sclerosis 4, Juvenile
Global Category
Genetic diseases;Metabolic diseases;Rare diseases
Anatomical Category
Mental diseases;Neuronal diseases;Respiratory diseases
Disease Name
Frontotemporal Dementia
Global Category
Genetic diseases;Rare diseases
Anatomical Category
Mental diseases;Neuronal diseases
Disease Name
Frontotemporal Dementia and/or Amyotrophic Lateral Sclerosis 3
Global Category
Genetic diseases;Rare diseases
Anatomical Category
Bone diseases;Mental diseases;Neuronal diseases
Disease Name
Frontotemporal Lobar Degeneration with Tdp43 Inclusions, Grn-Related
Global Category
Genetic diseases;Rare diseases
Anatomical Category
Mental diseases;Neuronal diseases
Disease Name
Juvenile Amyotrophic Lateral Sclerosis
Global Category
Genetic diseases;Metabolic diseases;Rare diseases
Anatomical Category
Mental diseases;Neuronal diseases;Respiratory diseases
Disease Definition
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive muscular paralysis reflecting degeneration of motor neurons in the primary motor cortex, corticospinal tBehavioral variant of frontotemporal dementia (bv-FTD) is a form of frontotemporal dementia (FTD; see this term), characterized by progressive behavioral impairment and a decline in executive functionJuvenile amyotrophic lateral sclerosis (JALS) is a very rare severe motor neuron disease characterized by progressive upper and lower motor neuron degeneration causing facial spasticity, dysarthria, aKennedy's disease, also known as bulbospinal muscular atrophy (BSMA), is a rare X-linked recessive motor neuron disease characterized by proximal and bulbar muscle wasting.MSH2017_2016_08_12:Diseases characterized by a selective degeneration of the motor neurons of the spinal cord, brainstem, or motor cortex. Clinical subtypes are distinguished by the major site of degeneration. In AMYOTROPHIC LATERAL SCLEROSIS there is involvement of upper, lower, and brainstem motor neurons. In progressive muscular atrophy and related syndromes (see MUSCULAR ATROPHY, SPINAL) the motor neurons in the spinal cord are primarily affected. With progressive bulbar palsy (BULBAR PALSY, PROGRESSIVE), the initial degeneration occurs in the brainstem. In primary lateral sclerosis, the cortical neurons are affected in isolation. (Adams et al., Principles of Neurology, 6th ed, p1089)|CSP2006:disorders of motor neurons which result in atrophy, fasciculation and fibrillations, spasticity, decreased muscle tone, loss of or overactive tendon reflexes, and abnormal extensor reflexes.NCI2016_02D:A rare neurodegenerative disorder leading to dementia. It is characterized by frontotemporal lobar degeneration with accumulation of tau proteins which form Pick bodies.|MSH2017_2016_08_12:A rare form of DEMENTIA that is sometimes familial. Clinical features include APHASIA; APRAXIA; CONFUSION; ANOMIA; memory loss; and personality deterioration. This pattern is consistent with the pathologic findings of circumscribed atrophy of the poles of the FRONTAL LOBE and TEMPORAL LOBE. Neuronal loss is maximal in the HIPPOCAMPUS, entorhinal cortex, and AMYGDALA. Some ballooned cortical neurons contain argentophylic (Pick) bodies. (From Brain Pathol 1998 Apr;8(2):339-54; Adams et al., Principles of Neurology, 6th ed, pp1057-9)NCI2016_02D:A rare neurologic progressive disorder characterized by impairment of the language and speech abilities.|MSH2017_2016_08_12:A progressive form of dementia characterized by the global loss of language abilities and initial preservation of other cognitive functions. Fluent and nonfluent subtypes have been described. Eventually a pattern of global cognitive dysfunction, similar to ALZHEIMER DISEASE, emerges. Pathologically, there are no Alzheimer or PICK DISEASE like changes, however, spongiform changes of cortical layers II and III are present in the TEMPORAL LOBE and FRONTAL LOBE. (From Brain 1998 Jan;121(Pt 1):115-26)NCI2016_02D:A syndrome caused by progressive degeneration of the frontal or temporal lobes of the brain. It is manifested with personality changes and deterioration of the language skills.|MSH2017_2016_08_12:The most common clinical form of FRONTOTEMPORAL LOBAR DEGENERATION, this dementia presents with personality and behavioral changes often associated with disinhibition, apathy, and lack of insight.|HPO2016_07_04:A dementia associated with degeneration of the frontotemporal lobe and clinically associated with personality and behavioral changes such as disinhibition, apathy, and lack of insight. The hallmark feature of frontotemporal dementia is the presentation with focal syndromes such as progressive language dysfunction, or aphasia, or behavioral changes characteristic of frontal lobe disorders. [HPO:probinson, pmid:24966676]Progressive non-fluent aphasia (PNFA) is a form of frontotemporal dementia (FTD; see this term), characterized by agrammatism, laborious speech, alexia, and agraphia, frequently accompanied by apraxia
Me Sh Disease Class
Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System DiseasesMental Disorders; Nervous System DiseasesMental Disorders; Nervous System Diseases; Pathological Conditions, Signs and SymptomsNervous System DiseasesNervous System Diseases; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Respiratory Tract DiseasesNervous System Diseases; Mental Disorders; Nutritional and Metabolic DiseasesNervous System Diseases; Nutritional and Metabolic Diseases
Dis Ge Net Disease Type
disease
Disease Class Name Me Sh
Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System DiseasesCongenital, Hereditary, and Neonatal Diseases and Abnormalities; Respiratory Tract Diseases; Nervous System DiseasesNervous System DiseasesNervous System Diseases; Mental DisordersNutritional and Metabolic Diseases; Nervous System DiseasesNutritional and Metabolic Diseases; Nervous System Diseases; Mental DisordersPathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders
Umls Semantic Type Name
Disease or SyndromeMental or Behavioral Dysfunction