DiseaseID 4570
胶质瘤
disease
HPO2016_07_04:A tumor arising from glia in the central nervous system with macroscopic regions of necrosis and hemorrhage. Microscopically, glioblastoma multiforme is characterized by regions of pseudopalisading necrosis
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Disease: 1Experiment: 7Formula: 15Herb: 12Symptom: 12Target: 22Links: 70
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Record Fields
Scalar fields from the final disease record.
- Disease Id
- 4570
- Core Entity Id
- 60939
- Source Entity Count
- 1
- Preferred Name
- Glioma
- Name Cn
- 胶质瘤
- Name Pinyin
- Jiao Zhi Liu
- Name En
- Glioma
- Name Latin
- Bilingual Status
- complete
- Disease Type
- disease
- Umls Disease Type
- Finding
- Disgenet Type
- disease
- Mesh Class
- NeoplasmsNeoplasms; Musculoskeletal DiseasesNervous System Diseases; NeoplasmsNervous System Diseases; Skin and Connective Tissue Diseases; Neoplasms
- Do Class
- disease of anatomical entity; disease of cellular proliferationdisease of cellular proliferation
- Hpo Class
- NeoplasmNeoplasm; Abnormality of the nervous system
- Mesh Class Name
- NeoplasmsNeoplasms; Musculoskeletal DiseasesNeoplasms; Nervous System DiseasesNeoplasms; Skin and Connective Tissue Diseases; Nervous System Diseases
- Hpo Class Name
- Abnormality of the nervous system; NeoplasmNeoplasm
- Do Class Name
- disease of anatomical entity; disease of cellular proliferationdisease of cellular proliferation
- Disease Definition
- HPO2016_07_04:A tumor arising from glia in the central nervous system with macroscopic regions of necrosis and hemorrhage. Microscopically, glioblastoma multiforme is characterized by regions of pseudopalisading necrosis, pleomorphic nuclei and cells, and microvascular proliferation. [HPO:probinson, pmid:10841526]|CSP2006:malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage and necrosis; may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways.|CHV2011_02:a type of brain tumor|CHV2011_02:a type of brain tumor
- Version
- v1
- Suppressed
- No
Names
Preferred names, aliases, and source labels retained in the final schema.
Name
Glioma
Role
preferred
Name
Adult Glioblastoma
Role
preferred
Name
Adult Oligodendrogliomas
Role
preferred
Name
Adult Subependymal Astrocytoma
Role
preferred
Name
Anaplastic Astrocytoma
Role
preferred
Name
Anaplastic Ependymoma
Role
preferred
Name
Anaplastic Oligodendroglioma
Role
preferred
Name
Astrocytoma
Role
preferred
Name
Central Nervous System Neoplasms
Role
preferred
Name
Childhood Oligodendrogliomas
Role
preferred
Name
Desmoplastic Medulloblastoma
Role
preferred
Name
Diffuse Astrocytoma
Role
preferred
Name
Ependymoblastoma
Role
preferred
Name
Ependymoma
Role
preferred
Name
Ewing Sarcoma
Role
preferred
Name
Ewings Sarcoma-Primitive Neuroectodermal Tumor (Pnet)
Role
preferred
Name
Fibrillary Astrocytoma
Role
preferred
Name
Gemistocytic Astrocytoma
Role
preferred
Name
Giant Cell Glioblastoma
Role
preferred
Name
Glioblastoma
Role
preferred
Name
Glioblastoma Multiforme
Role
preferred
Name
Glioma Susceptibility 1
Role
preferred
Name
Juvenile Pilocytic Astrocytoma
Role
preferred
Name
Localized Primitive Neuroectodermal Tumor
Role
preferred
Name
Medulloblastoma
Role
preferred
Name
Medulloblastoma With Extensive Nodularity
Role
preferred
Name
Medulloblastoma, Adult
Role
preferred
Name
Medulloblastoma, Childhood
Role
preferred
Name
Medulloepithelioma
Role
preferred
Name
Medullomyoblastoma
Role
preferred
Name
Melanotic Medulloblastoma
Role
preferred
Name
Mixed Oligodendroglioma-Astrocytoma
Role
preferred
Name
Myxopapillary Ependymoma
Role
preferred
Name
Neuroectodermal Tumor, Primitive
Role
preferred
Name
Neuroectodermal Tumors
Role
preferred
Name
Oligodendroglioma
Role
preferred
Name
Pilocytic Astrocytoma
Role
preferred
Name
Protoplasmic Astrocytoma
Role
preferred
Name
Subependymal Giant Cell Astrocytoma
Role
preferred
Name
Subependymal Glioma
Role
preferred
Name
Well Differentiated Oligodendroglioma
Role
preferred
Name
Adult Medulloblastoma
Role
preferred
Name
Adult Oligodendroglioma
Role
preferred
Name
Adult Subependymoma
Role
preferred
Name
Anaplastic Oligoastrocytoma
Role
preferred
Name
Askin'S Tumor
Role
preferred
Name
Astrocytoma, Low Grade
Role
preferred
Name
Cellular Ependymoma
Role
preferred
Name
Central Nervous System Embryonal Tumor, Not Otherwise Specified
Role
preferred
Name
Central Nervous System Neoplasms, Primary
Role
preferred
Name
Cerebral Astrocytoma
Role
preferred
Name
Cerebral Primitive Neuroectodermal Tumor
Role
preferred
Name
Childhood Cerebral Astrocytoma
Role
preferred
Name
Childhood Medulloblastoma
Role
preferred
Name
Childhood Oligodendroglioma
Role
preferred
Name
Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor
Role
preferred
Name
Ewings Sarcoma
Role
preferred
Name
Glioblastoma, IDH-Wildtype
Role
preferred
Name
Grade I Astrocytoma
Role
preferred
Name
Intracranial Astrocytoma
Role
preferred
Name
Juvenile Astrocytoma
Role
preferred
Name
Localized Ewing Sarcoma
Role
preferred
Name
Malignant Central Nervous System Neoplasm
Role
preferred
Name
Malignant Glioma
Role
preferred
Name
Mixed Gliomas
Role
preferred
Name
Mixed Oligoastrocytoma
Role
preferred
Name
Mixed Oligodendroglioma-Ependymoma
Role
preferred
Name
Neuroepithelioma, Peripheral
Role
preferred
Name
Oligodendroblastoma
Role
preferred
Name
Oligodendroglial Neoplasm
Role
preferred
Name
Papillary Ependymoma
Role
preferred
Name
Round Cell Sarcoma
Role
preferred
Name
Spongioblastoma
Role
preferred
Name
Supratentorial Embryonal Tumor, Not Otherwise Specified
Role
preferred
Name
Tanycytic Ependymoma
Role
preferred
Name
Undifferentiated Round Cell Sarcoma
Role
preferred
Name
ASKIN TUMOR
Role
alias
Name
Astrocytoma, Anaplastic
Role
alias
Name
Astrocytoma, Gemistocytic
Role
alias
Name
Astrocytoma, Grade Ii
Role
alias
Name
Astrocytoma, Protoplasmic
Role
alias
Name
Benign Ependymoma
Role
alias
Name
Central Nervous System Cancer
Role
alias
Name
Central Nervous System, Unspecified
Role
alias
Name
Central Primitive Neuroectodermal Tumor
Role
alias
Name
ES
Role
alias
Name
Ependymoma, Myxopapillary
Role
alias
Name
Ependymoma, Papillary
Role
alias
Name
Ewing'S Sarcoma
Role
alias
Name
GBM
Role
alias
Name
GLIOMA OF BRAIN, FAMILIAL
Role
alias
Name
GLM
Role
alias
Name
GLM1
Role
alias
Name
Glioma, Subependymal
Role
alias
Name
Gliomas, Mixed
Role
alias
Name
Grade Iii Astrocytoma
Role
alias
Name
MBEN
Role
alias
Name
MDB
Role
alias
Name
MEDULLOBLASTOMA, DESMOPLASTIC
Role
alias
Name
Malignant Neoplasm of Central Nervous System, Unspecified
Role
alias
Name
Malignant Neoplasm of The Central Nervous System
Role
alias
Name
Melanocytic Medulloblastoma
Role
alias
Name
Mixed Glioma
Role
alias
Name
Neoplasia of The Central Nervous System
Role
alias
Name
Neoplasm of The Central Nervous System
Role
alias
Name
Neuroectodermal Neoplasm
Role
alias
Name
Neuroectodermal Tumor
Role
alias
Name
Neuroectodermal Tumor, Peripheral
Role
alias
Name
Neuroectodermal Tumors, Primitive
Role
alias
Name
Neuroectodermal Tumors, Primitive, Peripheral
Role
alias
Name
Nodular Medulloblastoma
Role
alias
Name
Oligoastrocytoma, Mixed
Role
alias
Name
PNE
Role
alias
Name
Peripheral Neuroepithelioma
Role
alias
Name
Peripheral Primitive Neuroectodermal Neoplasm
Role
alias
Name
Primitive Neuroectodermal Tumor
Role
alias
Name
SUBEPENDYMOMA
Role
alias
Name
Sarcoma, Ewing
Role
alias
Name
Sarcoma, Ewings
Role
alias
Name
Small Cell Sarcoma
Role
alias
Name
Subependymal Astrocytoma, Adult
Role
alias
Name
Supratentorial Primitive Neuroectodermal Tumor
Role
alias
Name
Tumors of The Central Nervous System
Role
alias
Cross References
Trusted external identifiers retained for this final record.
Hpo
HP:0002885HP:0002888HP:0006717HP:0009592HP:0009718HP:0009733HP:0012174HP:0012254HP:0030061HP:0030065HP:0030066HP:0030067HP:0030070HP:0030071HP:0100006HP:0100836
Herb
HBDIS000268HBDIS000946HBDIS001169HBDIS001170HBDIS001882HBDIS002166HBDIS003249HBDIS004297HBDIS004298HBDIS004308HBDIS004332HBDIS004404HBDIS004451HBDIS005485HBDIS006956HBDIS007040HBDIS007042HBDIS007058HBDIS007188HBDIS007198HBDIS007199HBDIS007201HBDIS007203HBDIS007210HBDIS007599HBDIS007600HBDIS007601HBDIS007602HBDIS007603HBDIS007604HBDIS007605HBDIS007608HBDIS007609HBDIS007611HBDIS007646HBDIS008212HBDIS008430HBDIS009305HBDIS010106HBDIS010154HBDIS010155HBDIS010190HBDIS010580HBDIS010687HBDIS011092HBDIS011093HBDIS011225HBDIS011275HBDIS011276HBDIS011386HBDIS011413HBDIS012215HBDIS012318HBDIS013129HBDIS013466HBDIS013524HBDIS013820HBDIS013875HBDIS013887HBDIS013989HBDIS014054HBDIS014083HBDIS014375HBDIS014663HBDIS014734HBDIS019895HBDIS021434HBDIS021606HBDIS022739HBDIS025307
Me Sh
D001254D004806D005909D005910D008527D009837D012512D016543D017599D018241D018242D018315
Omim
137800155255612219
Umls
C0004114C0014474C0017636C0017638C0025149C0028945C0085136C0205768C0205769C0205833C0206093C0206663C0206725C0278510C0278876C0278878C0279070C0280475C0280783C0280785C0280788C0280793C0281328C0334579C0334580C0334581C0334582C0334583C0334588C0334590C0334596C0553580C0684337C0700367C0751291C0751396C0877849C1275668C1334410C1334970C1621958C1842010C2750850C3489398
Icd10
C72.9
Sym Map
SMDE01512SMDE04543SMDE04820SMDE05589SMDE05597SMDE05606SMDE05821SMDE05831SMDE05835SMDE06100SMDE06854SMDE07021SMDE07840SMDE07906SMDE08338SMDE08339SMDE08531SMDE08532SMDE08733SMDE08974SMDE09023SMDE09047SMDE09049SMDE09051SMDE10136SMDE10502SMDE10803SMDE10805SMDE10806SMDE10807SMDE10808SMDE10823SMDE11056SMDE11272SMDE11433SMDE11434SMDE11594SMDE12169SMDE12494SMDE13708SMDE13709SMDE14359
Do Class
DOID:14566DOID:7
Dis Ge Net
C0004114C0014474C0017636C0017638C0025149C0028945C0085136C0205768C0205769C0205833C0206093C0206663C0206725C0259783C0278510C0278876C0278878C0279070C0280475C0280783C0280785C0280788C0280793C0281328C0334578C0334579C0334580C0334581C0334582C0334583C0334584C0334588C0334590C0334596C0338070C0344461C0348374C0431108C0547065C0553580C0553581C0555198C0684337C0700367C0750935C0750936C0751291C0751395C0751396C0751620C0751675C0863029C0877849C1275668C1314694C1321865C1334410C1334970C1335110C1336538C1370500C1384403C1514422C1621958C1704230C2750850C3489398C3536893C3887678C4048304
Umls Sty
T033T191
Hpo Class
HP:0000707HP:0002664
Me Sh Class
C04C05C10C17
Etcm Disease
Ewing SarcomaGlioma Susceptibility 1Medulloblastoma
Tcmbank Disease
1043910546111011121123111481118751201712148125081254126901270313072133791487915478154931558015706162321694218488185621871118735197372021207202138021662216952179923797238432418524350249032529925889260152607326176262752820828283285932930629714297430042300863025330318306053072431027313323189032137346039644196638669087032784680668277838684628685898991449603
Itcmdb Generated
ITX-DISEASE-0550CC8ED0CDITX-DISEASE-06118A7104CDITX-DISEASE-07F23D43BA5BITX-DISEASE-0AB5AF11F6D2ITX-DISEASE-1D02D7DC8BBEITX-DISEASE-1E6EFF5BE34EITX-DISEASE-22FC5E00817FITX-DISEASE-28B7F419A2F3ITX-DISEASE-2B4ABF8414C0ITX-DISEASE-372AA5260B81ITX-DISEASE-380F772975ACITX-DISEASE-3C55C66983CBITX-DISEASE-5143D97A75F2ITX-DISEASE-59151F440739ITX-DISEASE-5B21AD6E2535ITX-DISEASE-5DD6D2B4CAF5ITX-DISEASE-6B6D80AB819EITX-DISEASE-7FAD42185AB9ITX-DISEASE-8BC2E3E4DD27ITX-DISEASE-8E89D1A9E994ITX-DISEASE-904964BBB0DCITX-DISEASE-91417876661BITX-DISEASE-91653036F7C8ITX-DISEASE-99168650C8DBITX-DISEASE-A33AA671D6BCITX-DISEASE-A631B01933B7ITX-DISEASE-ABA6FCC32847ITX-DISEASE-AD4E325B1A17ITX-DISEASE-ADF2EE9A7B8EITX-DISEASE-B1FEF37E94D8ITX-DISEASE-B3BA11ABA52BITX-DISEASE-B3CD7E7F2689ITX-DISEASE-B65A281060AAITX-DISEASE-B71E298D7ADBITX-DISEASE-B77CFF6A66A3ITX-DISEASE-BCBF81932FD3ITX-DISEASE-C5DE1DFE3854ITX-DISEASE-D896B75A4DB7ITX-DISEASE-EB7CFF3989FAITX-DISEASE-F73783587000ITX-DISEASE-F9040AA343CC
Attributes
Merged source attributes and domain-specific metadata.
Version
v1v1,v2v2
Suppress
0
Page Title
Disease Ewing Sarcoma Details pageDisease Glioma Susceptibility 1 Details pageDisease Medulloblastoma Details page
Do Class Name
disease of anatomical entity; disease of cellular proliferationdisease of cellular proliferation
Disease Type
diseasegroupphenotype
Hpo Class Name
Abnormality of the nervous system; NeoplasmNeoplasm
Do Disease Class
disease of anatomical entity; disease of cellular proliferationdisease of cellular proliferation
Hpo Disease Class
NeoplasmNeoplasm; Abnormality of the nervous system
Umls Disease Type
FindingNeoplastic Process
Basic Information
Disease Name
Ewing Sarcoma
Global Category
Cancer diseases;Genetic diseases;Rare diseases
Anatomical Category
Bone diseases;Neuronal diseases;Respiratory diseases
Disease Name
Glioma Susceptibility 1
Global Category
Cancer diseases;Genetic diseases;Rare diseases
Anatomical Category
Neuronal diseases
Disease Name
Medulloblastoma
Global Category
Cancer diseases;Fetal diseases;Genetic diseases;Rare diseases
Anatomical Category
Immune diseases;Neuronal diseases
Disease Definition
HPO2016_07_04:A tumor arising from glia in the central nervous system with macroscopic regions of necrosis and hemorrhage. Microscopically, glioblastoma multiforme is characterized by regions of pseudopalisading necrosis, pleomorphic nuclei and cells, and microvascular proliferation. [HPO:probinson, pmid:10841526]|CSP2006:malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage and necrosis; may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways.|CHV2011_02:a type of brain tumor|CHV2011_02:a type of brain tumorMSH2017_2016_08_12:A relatively slow-growing glioma that is derived from oligodendrocytes and tends to occur in the cerebral hemispheres, thalamus, or lateral ventricle. They may present at any age, but are most frequent in the third to fifth decades, with an earlier incidence peak in the first decade. Histologically, these tumors are encapsulated, relatively avascular, and tend to form cysts and microcalcifications. Neoplastic cells tend to have small round nuclei surrounded by unstained nuclei. The tumors may vary from well-differentiated to highly anaplastic forms. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, p2052; Adams et al., Principles of Neurology, 6th ed, p655)MSH2017_2016_08_12:Malignant neoplasms arising in the neuroectoderm, the portion of the ectoderm of the early embryo that gives rise to the central and peripheral nervous systems, including some glial cells.|HPO2016_07_04:A neoplasm arising in the neuroectoderm, the portion of the ectoderm of the early embryo that gives rise to the central and peripheral nervous systems, including some glial cells. []NCI2016_02D:A benign, slowly growing tumor (WHO grade I) typically arising in the wall of the lateral ventricles and composed of large ganglioid astrocytes. It is the most common CNS neoplasm in patients with tuberous sclerosis complex and typically occurs during the first two decades of life. (WHO)|HPO2016_07_04:A demarcated, largely intraventricular tumor in the region of the foramen of Monro composed of spindle to large plump or ganglion-like cells with eosinophilic to amphophilic cytoplasm and somewhat pleomorphic nuclei with occasional prominent nucleoli. These tumors are almost always associated with tuberous sclerosis. [HPO:curators]NCI2016_02D:A medulloblastoma characterized by nodularity and neuronal differentiation.NCI2016_02D:A medulloblastoma characterized by the presence of nodular, collagenous areas which do not contain reticulin, surrounded by hypercellular areas which contain an intercellular reticulin fiber network.NCI2016_02D:A medulloblastoma occurring in adults.NCI2016_02D:A medulloblastoma occurring in children.NCI2016_02D:A rare histological variant of glioblastoma (WHO grade IV) with a predominance of bizarre, multinucleated giant cells, an occasionally abundant stromal reticulin network, and a high frequency of TP53 mutations. (WHO)NCI2016_02D:A rare malignant embryonal neoplasm arising from the cerebellum. It is characterized by the morphologic features of a medulloblastoma and the presence of a striated muscle component. Its clinical behavior is similar to medulloblastoma.NCI2016_02D:A rare malignant embryonal neoplasm characterized by the presence of small cells which resemble the cells of classic medulloblastoma and a minor population of melanin-forming neuroepithelial cells. It usually has an unfavorable clinical course.NCI2016_02D:A rare variant of diffuse astrocytoma. It is characterized by the presence of a conspicuous, though variable, fraction of gemistocytic neoplastic astrocytes. Gemistocytes are round to oval astrocytes with abundant, glassy, non-fibrillary cytoplasm which appears to displace the dark, angulated nucleus to the periphery of the cell. To make the diagnosis of gemistocytic astrocytoma, gemistocytes should amount to more than approximately 20% of all tumor cells. (Adapted from WHO)NCI2016_02D:A rare variant of diffuse astrocytoma. It is predominantly composed of neoplastic astrocytes showing a small cell body with few, flaccid processes with a low content of glial filaments and scant GFAP expression. This lesion is not well defined and is considered by some authors as an occasional histopathological feature rather than a reproducibly identifiable variant. When occurring in children, this neoplasm may be difficult to separate from pilocytic juvenile astrocytoma. (Adapted from WHO)NCI2016_02D:A rare, usually aggressive malignant embryonal neoplasm of the central nervous system occurring in children. It is characterized by the presence of neuroepithelial cells which form papillary, trabecular, or tubular structures. Symptoms include headache, nausea, and vomiting.|NCI2016_02D:A rare, unilateral, benign or malignant embryonic neoplasm typically presenting as a cilliary body mass during childhood. It is composed of medullary epithelial cells.|HPO2016_07_04:A primitive neuroectodermal tumor that originates from the cells of the embryonic medullary canal. [pmid:17566306]NCI2016_02D:A subependymoma that occurs during adulthood.NCI2016_02D:An oligodendroglioma occurring during adulthood.NCI2016_02D:An oligodendroglioma that arises from the central nervous system and occurs during childhood.NCI2016_02D:The most frequent histological variant of diffuse astrocytoma. It is predominantly composed of fibrillary neoplastic astrocytes. Nuclear atypia is a diagnostic criterion but mitotic activity, necrosis and microvascular proliferation are absent. The occasional or regional occurrence of gemistocytic neoplastic cells is compatible with the diagnosis of fibrillary astrocytoma. (WHO)NCI2016_CDISC_1602D:A benign neoplasm of ependymal origin.|NCI2016_02D:A slow growing, WHO grade I glioma which generally occurs in young adults. It arises almost exclusively in the conus medullaris, cauda equina, and filum terminale of the spinal cord. It generally has a favorable prognosis and is characterized histologically by tumor cells arranged in a papillary manner around vascularized mucoid stromal cores. (Adapted from WHO).NCI2016_CDISC_1602D:A benign neoplasm of the brain localized in the vicinity of a ventricular wall and is composed of glial tumor cell clusters embedded in an abundant fibrillary matrix with frequent microcystic changes.|NCI2016_02D:A benign, slow growing neoplasm which is typically attached to a ventricular wall. It is composed of glial tumor cell clusters embedded in an abundant fibrillary matrix with frequent microcystic change. Some lesions have the histological features of both subependymoma and ependymoma. It is often detected incidentally and has a very favorable prognosis. (Adapted from WHO.)|MSH2017_2016_08_12:Rare, slow-growing, benign intraventricular tumors, often asymptomatic and discovered incidentally. The tumors are classified histologically as ependymomas and demonstrate a proliferation of subependymal fibrillary astrocytes among the ependymal tumor cells. (From Clin Neurol Neurosurg 1997 Feb;99(1):17-22)NCI2016_CDISC_1602D:A benign neoplasm of the brain or spinal cord arising from astrocytes associated with single or multiple cysts.|NCI2016_02D:A WHO grade I, relatively circumscribed, slowly growing, often cystic astrocytoma occurring in children and young adults. Histologically it is characterized by a biphasic pattern with compacted bipolar cells associated with Rosenthal fibers and multipolar cells associated with microcysts and eosinophilic bodies/hyaline droplets. (WHO)NCI2016_CDISC_1602D:A malignant astrocytic neoplasm characterized by a high degree of cellular differentiation, slow growth, and diffuse infiltration of neighboring brain structures.|NCI2016_02D:A low-grade (WHO grade II) astrocytic neoplasm. It is characterized by a high degree of cellular differentiation, slow growth, and diffuse infiltration of neighboring brain structures. These lesions typically affect young adults and have an intrinsic tendency for malignant progression to anaplastic astrocytoma and, ultimately, glioblastoma. According to the prevailing cells type, three major variants can be distinguished: fibrillary astrocytoma, gemistocytic astrocytoma, and protoplasmic astrocytoma. (Adapted from WHO)NCI2016_CDISC_1602D:A malignant neoplasm of ependymal origin with anaplastic cellular morphology.|NCI2016_02D:A WHO grade III malignant glioma of ependymal origin with accelerated growth and an unfavorable clinical outcome, particularly in children. It is characterized by high mitotic activity, often accompanied by microvascular proliferation and pseudo-palisading necrosis. (Adapted from WHO)NCI2016_CDISC_1602D:A malignant neoplasm of the brain or spinal cord originating from astrocytes, exhibiting poor differentiation (anaplasia).|NCI2016_02D:A diffusely infiltrating, WHO grade III astrocytoma with focal or dispersed anaplasia, and a marked proliferative potential. It may arise from a low-grade astrocytoma, but it can also be diagnosed at first biopsy, without indication of a less malignant precursor lesion. It has an intrinsic tendency for malignant progression to glioblastoma. (WHO)NCI2016_CDISC_1602D:A malignant neoplasm of the central nervous system arising from oligodendrocytes, exhibiting poor differentiation (anaplasia).|NCI2016_02D:A WHO grade III oligodendroglioma with focal or diffuse malignant morphologic features (prominent nuclear pleomorphism, mitoses, and increased cellularity).NCI2016_NCI-GLOSS_1602D:A brain tumor that forms from both oligodendrocytes and astrocytes, which are types of glial cells (cells that cover and protect nerve cells in the brain and spinal cord and help them work the way they should). An oligoastrocytoma is a type of mixed glioma.|NCI2016_CDISC_1602D:A benign neoplasm of the central nervous system with an astrocytic and oligodendrocytic component.|NCI2016_02D:A WHO grade II tumor composed of a conspicuous mixture of two distinct neoplastic cell types morphologically resembling the tumor cells in oligodendroglioma and diffuse astrocytoma. (WHO)NCI2016_NCI-GLOSS_1602D:A fast-growing type of central nervous system tumor that forms from glial (supportive) tissue of the brain and spinal cord and has cells that look very different from normal cells. GBM usually occurs in adults and affects the brain more often than the spinal cord.|NCI2016_02D:The most malignant astrocytic tumor (WHO grade IV). It is composed of poorly differentiated neoplastic astrocytes and it is characterized by the presence of cellular polymorphism, nuclear atypia, brisk mitotic activity, vascular thrombosis, microvascular proliferation and necrosis. It typically affects adults and is preferentially located in the cerebral hemispheres. It may develop from diffuse astrocytoma WHO grade II or anaplastic astrocytoma (secondary glioblastoma), but more frequently, it manifests after a short clinical history de novo, without evidence of a less malignant precursor lesion (primary glioblastoma). Two histologic variants are recognized: giant cell glioblastoma and gliosarcoma. (WHO)|MSH2017_2016_08_12:A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures.|CHV2011_02:a type of brain tumor|CHV2011_02:a type of brain tumor|CHV2011_02:a type of brain tumor|CHV2011_02:a type of brain tumorNCI2016_NCI-GLOSS_1602D:A general term for tumors of the central nervous system, including astrocytomas, ependymal tumors, glioblastoma multiforme, and primitive neuroectodermal tumors.|NCI2016_CDISC_1602D:A neoplasm of the central nervous system composed of glial cells (astrocytes, oligodendrocytes, ependymal cells), for which the malignancy status has not been determined.|NCI2016_02D:A benign or malignant brain and spinal cord tumor that arises from glial cells (astrocytes, oligodendrocytes, ependymal cells). Tumors that arise from astrocytes are called astrocytic tumors or astrocytomas. Tumors that arise from oligodendrocytes are called oligodendroglial tumors. Tumors that arise from ependymal cells are called ependymomas.|MSH2017_2016_08_12:Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)|HPO2016_07_04:The presence of a glioma, which is a neoplasm of the central nervous system originating from a glial cell (astrocytes or oligodendrocytes). [HPO:probinson]|CSP2006:new abnormal neuroglial tissue in any one of its stages of development that grows by excessive cellular division and proliferation more rapidly than normal and continues to grow after the stimuli that initiated the new growth cease.|CHV2011_02:A general term for many types of tumors of the central nervous system|CHV2011_02:A general term for many types of tumors of the central nervous system|CHV2011_02:A general term for many types of tumors of the central nervous system|CHV2011_02:A general term for many types of tumors of the central nervous systemNCI2016_NCI-GLOSS_1602D:A rare, slow-growing tumor that begins in oligodendrocytes (cells that cover and protect nerve cells in the brain and spinal cord).|NCI2016_CDISC_1602D:A neoplasm of the central nervous system arising from oligodendrocytes, for which the malignancy status has not been determined.|NCI2016_02D:A well-differentiated (WHO grade II), diffusely infiltrating neuroglial tumor, typically located in the cerebral hemispheres. It is composed predominantly of cells which morphologically resemble oligodendroglia. The neoplastic cells have rounded homogeneous nuclei and, on paraffin sections, a swollen, clear cytoplasm ('honeycomb' appearance). (Adapted from WHO)NCI2016_NCI-GLOSS_1602D:A slow-growing type of central nervous system tumor that forms from glial (supportive) tissue of the brain and spinal cord. Juvenile pilocytic astrocytoma usually occurs in children and young adults. It forms in the brain more often than the spinal cord.|NCI2016_02D:A pilocytic astrocytoma that occurs during adolescence.NCI2016_NCI-GLOSS_1602D:A tumor of the central nervous system, including brain stem glioma, craniopharyngioma, medulloblastoma, and meningioma.|NCI2016_02D:A benign or malignant, primary or metastatic neoplasm that affects the brain, meninges, or spinal cord. Representative examples of primary neoplasms include astrocytoma, oligodendroglioma, ependymoma, and meningioma. Representative examples of metastatic neoplasms include carcinoma and leukemia.|MSH2017_2016_08_12:Benign and malignant neoplastic processes that arise from or secondarily involve the brain, spinal cord, or meninges.|HPO2016_07_04:A neoplasm of the central nervous system. [HPO:probinson]|CSP2006:new abnormal central nervous system tissue that grows by excessive cellular division and proliferation more rapidly than normal and continues to grow after the stimuli that initiated the new growth cease; neoplastic processes that arise from or secondarily involve the brain, spinal cord, or meninges.NCI2016_NCI-GLOSS_1602D:A type of cancer that forms in bone or soft tissue.|NCI2016_02D:A small round cell tumor with neural differentiation arising from the soft tissues or bone.|MSH2017_2016_08_12:A group of highly cellular primitive round cell neoplasms which occur extracranially in soft tissue and bone and are derived from embryonal neural crest cells. These tumors occur primarily in children and adolescents and share a number of characteristics with EWING SARCOMA.|HPO2016_07_04:A primitive neuroectodermal neoplasm that occurs extracranially in soft tissue and bone. []NCI2016_NCI-GLOSS_1602D:One of a group of cancers that develop from the same type of early cells, and share certain biochemical and genetic features. Some PNETs develop in the brain and central nervous system (CNS-PNET), and others develop in sites outside of the brain such as the limbs, pelvis, and chest wall (peripheral PNET).|NCI2016_02D:A malignant neoplasm that originates in the neuroectoderm. The neuroectoderm constitutes the portion of the ectoderm of the early embryo that gives rise to the central and peripheral nervous systems and includes some glial cell precursors.|MSH2017_2016_08_12:A group of malignant tumors of the nervous system that feature primitive cells with elements of neuronal and/or glial differentiation. Use of this term is limited by some authors to central nervous system tumors and others include neoplasms of similar origin which arise extracranially (i.e., NEUROECTODERMAL TUMORS, PRIMITIVE, PERIPHERAL). This term is also occasionally used as a synonym for MEDULLOBLASTOMA. In general, these tumors arise in the first decade of life and tend to be highly malignant. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, p2059)|HPO2016_07_04:A tumor that originates in cells from the primitive neural crest. This group of tumors is characteirzed by the presence of primitive cells with elements of neuronal and/or glial differentiation. []NCI2016_NICHD_1602D:A malignant neoplasm arising from ependymal cells that line the ventricles of the brain and the central canal of the spinal cord.|NCI2016_NCI-GLOSS_1602D:A type of brain tumor that begins in cells lining the spinal cord central canal (fluid-filled space down the center) or the ventricles (fluid-filled spaces of the brain). Ependymomas may also form in the choroid plexus (tissue in the ventricles that makes cerebrospinal fluid).|NCI2016_CDISC_1602D:A neoplasm of ependymal origin, for which the malignancy status has not been established.|NCI2016_02D:A WHO grade II, slow growing tumor of children and young adults, usually located intraventricularly. It is the most common ependymal neoplasm. It often causes clinical symptoms by blocking cerebrospinal fluid pathways. Key histological features include perivascular pseudorosettes and ependymal rosettes. (WHO)(from WHO)|MSH2017_2016_08_12:Glioma derived from EPENDYMOGLIAL CELLS that tend to present as malignant intracranial tumors in children and as benign intraspinal neoplasms in adults. It may arise from any level of the ventricular system or central canal of the spinal cord. Intracranial ependymomas most frequently originate in the FOURTH VENTRICLE and histologically are densely cellular tumors which may contain ependymal tubules and perivascular pseudorosettes. Spinal ependymomas are usually benign papillary or myxopapillary tumors. (From DeVita et al., Principles and Practice of Oncology, 5th ed, p2018; Escourolle et al., Manual of Basic Neuropathology, 2nd ed, pp28-9)|HPO2016_07_04:The presence of an ependymoma of the central nervous system. [HPO:probinson]|CSP2006:gliomas derived from ependymocytes that tend to present as malignant intracranial tumors in children and as benign intraspinal neoplasms in adults; may arise from any level of the ventricular system or central canal of the spinal cord; intracranial ependymomas most frequently originate in the fourth ventricle and histologically are densely cellular tumors which may contain ependymal tubules and perivascular pseudorosettes; spinal ependymomas are usually benign papillary or myxopapillary tumors.NCI2016_NICHD_1602D:A malignant neoplasm of the bone, or the soft tissue adjacent to bone, that is comprised of primitive neuroectodermal cells.|NCI2016_NCI-GLOSS_1602D:A type of cancer that forms in bone or soft tissue.|NCI2016_02D:A small round cell tumor that lacks morphologic, immunohistochemical, and electron microscopic evidence of neuroectodermal differentiation. It represents one of the two ends of the spectrum called Ewing sarcoma/peripheral neuroectodermal tumor. It affects mostly males under age 20, and it can occur in soft tissue or bone. Pain and the presence of a mass are the most common clinical symptoms.|MSH2017_2016_08_12:A malignant tumor of the bone which always arises in the medullary tissue, occurring more often in cylindrical bones. The tumor occurs usually before the age of 20, about twice as frequently in males as in females.|HPO2016_07_04:A malignant tumor of the bone which always arises in the medullary tissue, occurring more often in cylindrical bones. [HPO:probinson, pmid:17272319]|CSP2006:malignant tumor of bones which always arises in medullary tissue, occurring more often in cylindrical bones, with pain, fever, and leukocytosis.NCI2016_NICHD_1602D:A malignant neoplasm of the central nervous system that arises from astrocytes.|NCI2016_NCI-GLOSS_1602D:A tumor that begins in the brain or spinal cord in small, star-shaped cells called astrocytes.|NCI2016_CDISC_1602D:A neoplasm of the brain or spinal cord exhibiting astrocytic differentiation, but in which the malignancy status has not been established.|NCI2016_02D:A tumor of the brain or spinal cord showing astrocytic differentiation. It includes the following clinicopathological entities: pilocytic astrocytoma, diffuse astrocytoma, anaplastic astrocytoma, pleomorphic xanthoastrocytoma, and subependymal giant cell astrocytoma.|NCI2016_02D:A glial tumor of the brain or spinal cord showing astrocytic differentiation. It includes the following clinicopathological entities: pilocytic astrocytoma, diffuse astrocytoma, anaplastic astrocytoma, pleomorphic xanthoastrocytoma, subependymal giant cell astrocytoma, and glioblastoma.|MSH2017_2016_08_12:Neoplasms of the brain and spinal cord derived from glial cells which vary from histologically benign forms to highly anaplastic and malignant tumors. Fibrillary astrocytomas are the most common type and may be classified in order of increasing malignancy (grades I through IV). In the first two decades of life, astrocytomas tend to originate in the cerebellar hemispheres; in adults, they most frequently arise in the cerebrum and frequently undergo malignant transformation. (From Devita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2013-7; Holland et al., Cancer Medicine, 3d ed, p1082)|HPO2016_07_04:Astrocytoma is a neoplasm of the central nervous system derived from astrocytes. Astrocytes are a type of glial cell, and thus astrocytoma is a subtype of glioma. [HPO:curators]|CSP2006:neoplasms composed of astrocytes of the brain and spinal cord derived from glial cells which vary from histologically benign forms to highly anaplastic and malignant tumors.|CHV2011_02:a kind of brain tumor|CHV2011_02:a kind of brain tumor|CHV2011_02:a kind of brain tumor|CHV2011_02:a kind of brain tumorNCI2016_NICHD_1602D:A rapidly progressive cancer of the brain that originates in the cerebellum.|NCI2016_NCI-GLOSS_1602D:A malignant brain tumor that begins in the lower part of the brain and that can spread to the spine or to other parts of the body. Medulloblastomas are a type of primitive neuroectodermal tumor (PNET).|NCI2016_CDISC_1602D:A malignant, invasive embryonal neoplasm arising from the cerebellum.|NCI2016_02D:A malignant, invasive embryonal neoplasm arising from the cerebellum. It occurs predominantly in children and has the tendency to metastasize via the cerebrospinal fluid pathways. Signs and symptoms include truncal ataxia, disturbed gait, lethargy, headache, and vomiting. There are four histologic variants: anaplastic medulloblastoma, desmoplastic/nodular medulloblastoma, large cell medulloblastoma, and medulloblastoma with extensive nodularity.|MSH2017_2016_08_12:A malignant neoplasm that may be classified either as a glioma or as a primitive neuroectodermal tumor of childhood (see NEUROECTODERMAL TUMOR, PRIMITIVE). The tumor occurs most frequently in the first decade of life with the most typical location being the cerebellar vermis. Histologic features include a high degree of cellularity, frequent mitotic figures, and a tendency for the cells to organize into sheets or form rosettes. Medulloblastoma have a high propensity to spread throughout the craniospinal intradural axis. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2060-1)|HPO2016_07_04:A rapidly growing embryonic tumor arising in the posterior part of the cerebellar vermis and neuroepithelial roof of the fourth ventricle in children. More rarely, medulloblastoma arises in the cerebellum in adults. [HPO:probinson]|CSP2006:malignant cerebellar neoplasm composed of undifferentiated neuroepithelial cells that may be classified either as a glioma or as a primitive neuroectodermal tumor of childhood; tumor occurs most frequently in the first decade of life with the most typical location being the cerebellar vermis.SNOMEDCT_US_2016_09_01:A rare type of primitive neuroectodermal tumour (PNET) that usually occurs in young children under the age of 2 and is histologically distinguished by the production of ependymoblastic rosettes. It is associated with an aggressive course and a poor prognosis.|SNOMEDCT_US_2016_09_01:A rare type of primitive neuroectodermal tumor (PNET) that usually occurs in young children under the age of 2 and is histologically distinguished by the production of ependymoblastic rosettes. It is associated with an aggressive course and a poor prognosis.|NCI2016_02D:An aggressive malignant embryonal neoplasm arising from the central nervous system. It is characterized by the presence of multilayered rosettes formation, and increased cellularity.|HPO2016_07_04:A highly malignant embryonal tumor of infancy and young childhood characterized by neuroectodermal elements organized in distinctive multilayered rosettes. Ependymoblastomas are large lesions that occur in the supratentorial compartment, typically displaying a physical connection to the ventricular system. []
Me Sh Disease Class
NeoplasmsNeoplasms; Musculoskeletal DiseasesNervous System Diseases; NeoplasmsNervous System Diseases; Skin and Connective Tissue Diseases; Neoplasms
Dis Ge Net Disease Type
diseasegroupphenotype
Disease Class Name Me Sh
NeoplasmsNeoplasms; Musculoskeletal DiseasesNeoplasms; Nervous System DiseasesNeoplasms; Skin and Connective Tissue Diseases; Nervous System Diseases
Umls Semantic Type Name
FindingNeoplastic Process