DiseaseID 4284

免疫球蛋白E水平增高

disease

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Disease: 1Formula: 7Herb: 12Symptom: 12Target: 23Links: 55

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Record Fields

Scalar fields from the final disease record.

Disease Id: 4284
Core Entity Id: 60610
Source Entity Count: 2
Preferred Name: Increased Ige Level
Name Cn: 免疫球蛋白E水平增高
Name Pinyin: Mian Yi Qiu Dan Bai E Shui Ping Zeng Gao
Name En: Increased Ige Level
Name Latin
Bilingual Status: complete
Disease Type: disease
Umls Disease Type: Disease or Syndrome
Disgenet Type: disease
Mesh Class: Immune System DiseasesImmune System Diseases; Respiratory Tract Diseases
Do Class
Hpo Class: Abnormality of metabolism/homeostasis; Abnormality of the immune system; Abnormal cellular phenotype
Mesh Class Name: Immune System DiseasesRespiratory Tract Diseases; Immune System Diseases
Hpo Class Name: Abnormality of metabolism/homeostasis; Abnormality of the immune system; Abnormal cellular phenotype
Do Class Name
Disease Definition: NCI2016_NICHD_1602D:An immunoglobulin E (IgE) mediated hypersensitivity reaction. These usually occur within an hour of exposure to an allergen.|NCI2016_02D:Immediate hypersensitivity reaction - type I reaction, involves immunoglobulin E (IgE)-mediated release of chemical mediators from mast cells and basophils. Th2 cells produce IL-4 and IL-13, which then act on B cells to promote the production of antigen-specific IgE. Reexposure to the antigen can then result in the antigen binding to and cross-linking the bound IgE antibodies on the mast cells and basophils. This causes the release of preformed mediators (histamine, tryptase, tryptase, chemotactic factors), newly synthesized mediators (leukotrienes, prostaglandin, thromboxane, platelet-activating factor, adenosine, bradykinin), and cytokines from these cells that results in structural and functional changes to the affected tissue.|MSH2017_2016_08_12:Hypersensitivity reactions which occur within minutes of exposure to challenging antigen due to the release of histamine which follows the antigen-antibody reaction and causes smooth muscle contraction and increased vascular permeability.|GO2016_05_01:An inflammatory response driven by antigen recognition by antibodies bound to Fc receptors on mast cells or basophils, occurring within minutes after exposure of a sensitized individual to the antigen, and leading to the release of a variety of inflammatory mediators such as histamines. [GOC:add, ISBN:0781735149]|CSP2006:hypersensitivity reactions which occur within minutes of exposure to challenging antigen due to the release of histamine which follows the antigen-antibody reaction and causes smooth muscle contraction and increased vascular permeability.
Version: v1,v2
Suppressed: No

Names

Preferred names, aliases, and source labels retained in the final schema.

Name

Increased Ige Level

Role

preferred

Name

ATOPY, SUSCEPTIBILITY TO (finding)

Role

preferred

Name

IgE RESPONSIVENESS, ATOPIC

Role

preferred

Name

Immediate Hypersensitivity

Role

preferred

Name

Atopic Hypersensitivity

Role

alias

Name

Atopy, Susceptibility To

Role

alias

Name

Elevated Immunoglobulin E

Role

alias

Name

Elevated Serum Ige

Role

alias

Name

High Immunoglobulin E

Role

alias

Name

Hypersensitivity, Immediate

Role

alias

Name

Ige, Elevated Level Of

Role

alias

Cross References

Trusted external identifiers retained for this final record.

Hpo

HP:0003212

Herb

HBDIS001458HBDIS005049HBDIS015830HBDIS015831

Me Sh

D006969

Omim

147050

Umls

C0020523C0236175C1840253C1840254

Sym Map

SMDE03599SMDE09786

Dis Ge Net

C0020523C0236175C1840253C1840254

Umls Sty

T033T046T047

Hpo Class

HP:0001939HP:0002715HP:0025354

Me Sh Class

C08C20

Etcm Disease

Ige Responsiveness, Atopic

Tcmbank Disease

135471637528790288515727

Itcmdb Generated

ITX-DISEASE-2BF740AE99C5ITX-DISEASE-604CBEE0915BITX-DISEASE-6A6231AC640C

Attributes

Merged source attributes and domain-specific metadata.

Version

v1,v2v2

Suppress

Page Title

Disease Ige Responsiveness, Atopic Details page

Disease Type

diseasephenotype

Hpo Class Name

Abnormality of metabolism/homeostasis; Abnormality of the immune system; Abnormal cellular phenotype

Hpo Disease Class

Abnormality of metabolism/homeostasis; Abnormality of the immune system; Abnormal cellular phenotype

Umls Disease Type

Disease or SyndromeFindingPathologic Function

Basic Information

Disease Name

Ige Responsiveness, Atopic

Global Category

Genetic diseases

Anatomical Category

Immune diseases

Disease Definition

NCI2016_NICHD_1602D:An immunoglobulin E (IgE) mediated hypersensitivity reaction. These usually occur within an hour of exposure to an allergen.|NCI2016_02D:Immediate hypersensitivity reaction - type I reaction, involves immunoglobulin E (IgE)-mediated release of chemical mediators from mast cells and basophils. Th2 cells produce IL-4 and IL-13, which then act on B cells to promote the production of antigen-specific IgE. Reexposure to the antigen can then result in the antigen binding to and cross-linking the bound IgE antibodies on the mast cells and basophils. This causes the release of preformed mediators (histamine, tryptase, tryptase, chemotactic factors), newly synthesized mediators (leukotrienes, prostaglandin, thromboxane, platelet-activating factor, adenosine, bradykinin), and cytokines from these cells that results in structural and functional changes to the affected tissue.|MSH2017_2016_08_12:Hypersensitivity reactions which occur within minutes of exposure to challenging antigen due to the release of histamine which follows the antigen-antibody reaction and causes smooth muscle contraction and increased vascular permeability.|GO2016_05_01:An inflammatory response driven by antigen recognition by antibodies bound to Fc receptors on mast cells or basophils, occurring within minutes after exposure of a sensitized individual to the antigen, and leading to the release of a variety of inflammatory mediators such as histamines. [GOC:add, ISBN:0781735149]|CSP2006:hypersensitivity reactions which occur within minutes of exposure to challenging antigen due to the release of histamine which follows the antigen-antibody reaction and causes smooth muscle contraction and increased vascular permeability.

Me Sh Disease Class

Immune System DiseasesImmune System Diseases; Respiratory Tract Diseases

Dis Ge Net Disease Type

diseasephenotype

Disease Class Name Me Sh

Immune System DiseasesRespiratory Tract Diseases; Immune System Diseases

Umls Semantic Type Name

Disease or SyndromeFindingPathologic Function