DiseaseID 26031

急性髓系白血病

Leukemia, Acute Myeloid

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Record Fields

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Disease Id: 26031
Core Entity Id: 118599
Source Entity Count: 1
Preferred Name: Leukemia, Acute Myeloid
Name Cn: 急性髓系白血病
Name Pinyin: Ji Xing Sui Xi Bai Xue Bing
Name En: Leukemia, Acute Myeloid
Name Latin
Bilingual Status: complete
Disease Type
Umls Disease Type
Disgenet Type
Mesh Class
Do Class
Hpo Class
Mesh Class Name
Hpo Class Name
Do Class Name
Disease Definition: NCI2016_NICHD_1602D:A rapidly progressive cancer of the blood and bone marrow consisting of the proliferation of abnormal myeloblasts, which are immature, dysfunctional white blood cells.|NCI2016_NCI-GLOSS_1602D:An aggressive (fast-growing) disease in which too many myeloblasts (immature white blood cells that are not lymphoblasts) are found in the bone marrow and blood.|NCI2016_02D:Acute myeloid leukemias that do not fulfill the criteria for inclusion in the group of acute myeloid leukemias which have recurrent genetic abnormalities or myelodysplastic changes, or are therapy-related. This category includes entities classified according to the French-American-British classification scheme.|NCI2016_02D:A clonal expansion of myeloid blasts in the bone marrow, blood or other tissues. The classification of acute myeloid leukemias (AMLs) encompasses four major categories: 1) AML with recurrent genetic abnormalities; 2) AML with multilineage dysplasia; 3) Therapy-related AML; 4) AML not otherwise categorized. The required bone marrow or peripheral blood blast percentage for the diagnosis of AML is 20% (WHO classification).|MSH2017_2016_08_12:Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that normally produce NEUTROPHILS; BASOPHILS; EOSINOPHILS; and MONOCYTES.|MEDLINEPLUS_20151021:<a href='https://www.nlm.nih.gov/medlineplus/leukemia.html'>Leukemia</a> is cancer of the white blood cells. White blood cells help your body fight infection. Your blood cells form in your bone marrow. In leukemia, however, the bone marrow produces abnormal white blood cells. These cells crowd out the healthy blood cells, making it hard for blood to do its work. In acute myeloid leukemia (AML), there are too many of a specific type of white blood cell called a myeloblast. AML is the most common type of acute leukemia in adults. This type of cancer usually gets worse quickly if it is not treated. Possible risk factors include smoking, previous chemotherapy treatment, and exposure to radiation. Symptoms of AML include: <ul> <li>Fever</li> <li>Shortness of breath</li> <li>Easy bruising or bleeding</li> <li>Bleeding under the skin</li> <li>Weakness or feeling tired</li> <li>Weight loss or loss of appetite</li> </ul> Tests that examine the blood and bone marrow diagnose AML. Treatments include chemotherapy, other drugs, radiation therapy, stem cell transplants, and targeted therapy. Targeted therapy uses substances that attack cancer cells without harming normal cells. Once the leukemia is in remission, you need additional treatment to make sure that it does not come back. NIH: National Cancer Institute|HPO2016_07_04:A form of leukemia characterized by overproduction of an early myeloid cell. [HPO:probinson]|CSP2006:leukemia commonly occurring after alkylating agent treatment; manifestations include pancytopenia, megaloblastic bone marrow, and nucleated red cells in peripheral marrow; patients usually have chromosomal abnormalities in marrow cells.|CSP2006:acute leukemia arising from myeloid tissue in which the granular, polymorphonuclear leukocytes and their precursors predominate.
Version: v1
Suppressed: No

Names

Preferred names, aliases, and source labels retained in the final schema.

Name

Leukemia, Acute Myeloid

Role

preferred

Cross References

Trusted external identifiers retained for this final record.

Umls

C0023467C3275959

Sym Map

SMDE01654

Etcm Disease

Leukemia, Acute Myeloid

Itcmdb Generated

ITX-DISEASE-3CA3E72C822C

Attributes

Merged source attributes and domain-specific metadata.

Version

Suppress

Page Title

Disease Leukemia, Acute Myeloid Details page

Basic Information

Disease Name

Leukemia, Acute Myeloid

Global Category

Cancer diseases;Genetic diseases;Rare diseases

Anatomical Category

Blood diseases;Immune diseases

Disease Definition

NCI2016_NICHD_1602D:A rapidly progressive cancer of the blood and bone marrow consisting of the proliferation of abnormal myeloblasts, which are immature, dysfunctional white blood cells.|NCI2016_NCI-GLOSS_1602D:An aggressive (fast-growing) disease in which too many myeloblasts (immature white blood cells that are not lymphoblasts) are found in the bone marrow and blood.|NCI2016_02D:Acute myeloid leukemias that do not fulfill the criteria for inclusion in the group of acute myeloid leukemias which have recurrent genetic abnormalities or myelodysplastic changes, or are therapy-related. This category includes entities classified according to the French-American-British classification scheme.|NCI2016_02D:A clonal expansion of myeloid blasts in the bone marrow, blood or other tissues. The classification of acute myeloid leukemias (AMLs) encompasses four major categories: 1) AML with recurrent genetic abnormalities; 2) AML with multilineage dysplasia; 3) Therapy-related AML; 4) AML not otherwise categorized. The required bone marrow or peripheral blood blast percentage for the diagnosis of AML is 20% (WHO classification).|MSH2017_2016_08_12:Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that normally produce NEUTROPHILS; BASOPHILS; EOSINOPHILS; and MONOCYTES.|MEDLINEPLUS_20151021:<a href='https://www.nlm.nih.gov/medlineplus/leukemia.html'>Leukemia</a> is cancer of the white blood cells. White blood cells help your body fight infection. Your blood cells form in your bone marrow. In leukemia, however, the bone marrow produces abnormal white blood cells. These cells crowd out the healthy blood cells, making it hard for blood to do its work. In acute myeloid leukemia (AML), there are too many of a specific type of white blood cell called a myeloblast. AML is the most common type of acute leukemia in adults. This type of cancer usually gets worse quickly if it is not treated. Possible risk factors include smoking, previous chemotherapy treatment, and exposure to radiation. Symptoms of AML include: <ul> <li>Fever</li> <li>Shortness of breath</li> <li>Easy bruising or bleeding</li> <li>Bleeding under the skin</li> <li>Weakness or feeling tired</li> <li>Weight loss or loss of appetite</li> </ul> Tests that examine the blood and bone marrow diagnose AML. Treatments include chemotherapy, other drugs, radiation therapy, stem cell transplants, and targeted therapy. Targeted therapy uses substances that attack cancer cells without harming normal cells. Once the leukemia is in remission, you need additional treatment to make sure that it does not come back. NIH: National Cancer Institute|HPO2016_07_04:A form of leukemia characterized by overproduction of an early myeloid cell. [HPO:probinson]|CSP2006:leukemia commonly occurring after alkylating agent treatment; manifestations include pancytopenia, megaloblastic bone marrow, and nucleated red cells in peripheral marrow; patients usually have chromosomal abnormalities in marrow cells.|CSP2006:acute leukemia arising from myeloid tissue in which the granular, polymorphonuclear leukocytes and their precursors predominate.