ReferenceID 892
Triglyceride-induced cardiac lipotoxicity is mitigated by Silybum marianum
Atherosclerosis
BACKGROUND AND AIMS: Silybum marianum (SM) is an herbal product with cytoprotective and antioxidant properties. We have previously demonstrated that SM ameliorates ventricular remodeling and improves cardiac performance.
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- Reference Id
- 892
- Evidence Id
- 17482
- Core Evidence Id
- 17482
- Source Reference Id
- 1770
- Herb2 Reference Id
- HBREF002567
- Subject Paper Key
- HERB005162_33857761
- Pubmed Id
- 33857761
- Doi
- 10.1016/j.atherosclerosis.2021.03.014
- Paper Title
- Triglyceride-induced cardiac lipotoxicity is mitigated by Silybum marianum
- Paper Abstract
- BACKGROUND AND AIMS: Silybum marianum (SM) is an herbal product with cytoprotective and antioxidant properties. We have previously demonstrated that SM ameliorates ventricular remodeling and improves cardiac performance. Here, we evaluated whether SM could exert beneficial effects against cardiac lipotoxicity in a pig model of closed-chest myocardial infarction (MI). METHODS: Study 1 investigated the effect of SM administration on lipid profile and any potential SM-related adverse effects. Animals received SM or placebo during 10 days and were afterward sacrificed. Study 2 evaluated the effectiveness of SM daily administration in reducing cardiac lipotoxicity in animals subjected to a 1.5h myocardial infarction (MI), who were subsequently reperfused for 2.5h and euthanized or kept under study for three weeks and then sacrificed. RESULTS: Animals administered a 10-day SM regime presented a sharp decline in plasma triglyceride levels vs. controls, with no other modifications in lipid profile. The decrease in triglyceride concentration was accompanied by a marked reduction in triglyceride intestinal absorption and glycoprotein-P expression. Three weeks post-MI the triglyceride content in the ischemic myocardium of the SM-treated animals was significantly lower than in the ischemic myocardium of placebo-controls. This effect was associated with an enhanced cardiac expression of PPARgamma and triglyceride clearance receptors. This long-term SM-administration induced a lower expression of lipid receptors in subcutaneous adipose tissue. No SM-related side-effects were registered. CONCLUSION: SM administration reduces plasma triglyceride levels through attenuation of triglyceride intestinal absorption and modulates cardiac lipotoxicity in the ischemic myocardium, likely contributing to improve ventricular remodeling.
- Journal
- Atherosclerosis
- Publish Year
- 2021
- Experiment Subject
- Experiment Type
- Animal Experiment
- Phenotype Related
- Cardiac Lipotoxicity; 1.5h Myocardial Infarction; Closed-chest Myocardial Infarction
- Paper Title Cn
- Paper Title En
- Triglyceride-induced cardiac lipotoxicity is mitigated by Silybum marianum
- Bilingual Status
- semi_complete