ReferenceID 636
Citri Reticulatae Pericarpium (Chenpi) Protects against Endothelial Dysfunction and Vascular Inflammation in Diabetic Rats
Nutrients
Dried tangerine peel ( Citri reticulatae Pericarpium , CRP; Chenpi in Chinese) possesses medicine and food homology with hypolipidemic, anti-inflammatory and antioxidant activities. This study aimed to explore the protec
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Record Fields
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- Reference Id
- 636
- Evidence Id
- 17226
- Core Evidence Id
- 17226
- Source Reference Id
- 1259
- Herb2 Reference Id
- HBREF002056
- Subject Paper Key
- HERB000775_36558380
- Pubmed Id
- 36558380
- Doi
- 10.3390/nu14245221
- Paper Title
- Citri Reticulatae Pericarpium (Chenpi) Protects against Endothelial Dysfunction and Vascular Inflammation in Diabetic Rats
- Paper Abstract
- Dried tangerine peel ( Citri reticulatae Pericarpium , CRP; Chenpi in Chinese) possesses medicine and food homology with hypolipidemic, anti-inflammatory and antioxidant activities. This study aimed to explore the protective effect of CRP extract on endothelial function and inflammation in type 2 diabetic rats and the related mechanisms. Type 2 diabetes mellitus was induced by high-fat diet (HFD)/streptozotocin (STZ) in male Sprague Dawley rats, and CRP extract was orally administered at 400 mg/kg/day for 4 weeks. Rat and mouse aortas were treated with high glucose and CRP extract ex vivo. The data showed that the ethanolic extract of CRP normalized blood pressure and the plasma lipid profile as well as the plasma levels of liver enzymes in diabetic rats. Impaired endothelium-dependent relaxations in aortas, carotid arteries and renal arteries were improved. CRP extract suppressed vascular inflammatory markers and induced AMPK activation in aortas of diabetic rats. Exposure to high glucose impaired vasodilation in aortas of rats and mice, and this impairment was prevented by co-incubation with CRP extract. In conclusion, our findings suggest that CRP extract protects endothelial function by inhibiting the vascular inflammatory state on activation of AMPK in diabetic rats.
- Journal
- Nutrients
- Publish Year
- 2022
- Experiment Subject
- mouse; rat; sprague-dawley rat
- Experiment Type
- Animal Experiment
- Phenotype Related
- Diabetic; Type 2 Diabetes Mellitus; Type 2 Diabetic
- Paper Title Cn
- Paper Title En
- Citri Reticulatae Pericarpium (Chenpi) Protects against Endothelial Dysfunction and Vascular Inflammation in Diabetic Rats
- Bilingual Status
- semi_complete