ReferenceID 4232
Mulberry Fruit Prevents Diabetes and Diabetic Dementia by Regulation of Blood Glucose through Upregulation of Antioxidative Activities and CREB/BDNF Pathway in Alloxan-Induced Diabetic Mice
Oxid Med Cell Longev
Although mulberry fruit has various beneficial effects, its effect on diabetes-related dementia remains unknown. We investigated whether the ethyl acetate fraction of ethanolic extract of mulberry fruit (MFE) could allev
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Record Fields
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- Reference Id
- 4232
- Evidence Id
- 20822
- Core Evidence Id
- 20822
- Source Reference Id
- 1721
- Herb2 Reference Id
- HBREF002518
- Subject Paper Key
- HERB004832_32454931
- Pubmed Id
- 32454931
- Doi
- 10.1155/2020/1298691
- Paper Title
- Mulberry Fruit Prevents Diabetes and Diabetic Dementia by Regulation of Blood Glucose through Upregulation of Antioxidative Activities and CREB/BDNF Pathway in Alloxan-Induced Diabetic Mice
- Paper Abstract
- Although mulberry fruit has various beneficial effects, its effect on diabetes-related dementia remains unknown. We investigated whether the ethyl acetate fraction of ethanolic extract of mulberry fruit (MFE) could alleviate biochemical and behavioral deficits in alloxan-induced diabetic mice. In the diabetic mice, MFE considerably abolished multiple deficits, e.g., body weight reduction; water and food intake increase; and hyperglycemia, hyperlipidemia, hypoinsulinism, and hypertrophy of the liver, kidneys, spleen, and brain. A 200 mg/kg MFE dose reduced malondialdehyde levels and improved antioxidant enzyme activity in the liver, kidney, and brain tissues. MFE attenuated hyperglycemia-induced memory impairments and acetylcholine deprivation, protected neuronal cells in CA1 and CA3 regions via p-CREB/BDNF pathway activation, and reduced amyloid-beta precursor protein and p-Tau expressions in the brain tissue. In conclusion, MFE exerts antidiabetic and neuroprotective effects by upregulating antioxidative activities and p-CREB/BDNF pathway in chronic diabetes. Therefore, MFE may be used as a therapeutic agent for diabetes and diabetic neurodegenerative diseases.
- Journal
- Oxid Med Cell Longev
- Publish Year
- 2020
- Experiment Subject
- mouse; mulberry
- Experiment Type
- Animal Experiment
- Phenotype Related
- Diabetic Neurodegenerative Diseases; Diabetes-related Dementia; Diabetic; Chronic Diabetes; Hypertrophy Of The Liver; Hyperglycemia; Hyperlipidemia; Hypoinsulinism; Diabetes; Hyperglycemia-induced Memory Impairments
- Paper Title Cn
- Paper Title En
- Mulberry Fruit Prevents Diabetes and Diabetic Dementia by Regulation of Blood Glucose through Upregulation of Antioxidative Activities and CREB/BDNF Pathway in Alloxan-Induced Diabetic Mice
- Bilingual Status
- semi_complete