ReferenceID 3376
Plant-Derived Exosomal MicroRNAs Shape the Gut Microbiota
Cell Host Microbe
The gut microbiota can be altered by dietary interventions to prevent and treat various diseases. However, the mechanisms by which food products modulate commensals remain largely unknown. We demonstrate that plant-deriv
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Record Fields
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- Reference Id
- 3376
- Evidence Id
- 19966
- Core Evidence Id
- 19966
- Source Reference Id
- 33
- Herb2 Reference Id
- HBREF000092
- Subject Paper Key
- HERB005017_30449315
- Pubmed Id
- 30449315
- Doi
- 10.1016/j.chom.2018.10.001
- Paper Title
- Plant-Derived Exosomal MicroRNAs Shape the Gut Microbiota
- Paper Abstract
- The gut microbiota can be altered by dietary interventions to prevent and treat various diseases. However, the mechanisms by which food products modulate commensals remain largely unknown. We demonstrate that plant-derived exosome-like nanoparticles (ELNs) are taken up by the gut microbiota and contain RNAs that alter microbiome composition and host physiology. Ginger ELNs (GELNs) are preferentially taken up by Lactobacillaceae in a GELN lipid-dependent manner and contain microRNAs that target various genes in Lactobacillus rhamnosus (LGG). Among these, GELN mdo-miR7267-3p-mediated targeting of the LGG monooxygenase ycnE yields increased indole-3-carboxaldehyde (I3A). GELN-RNAs or I3A, a ligand for aryl hydrocarbon receptor, are sufficient to induce production of IL-22, which is linked to barrier function improvement. These functions of GELN-RNAs can ameliorate mouse colitis via IL-22-dependent mechanisms. These findings reveal how plant products and their effects on the microbiome may be used to target specific host processes to alleviate disease.
- Journal
- Cell Host Microbe
- Publish Year
- 2018
- Experiment Subject
- mouse
- Experiment Type
- Animal Experiment
- Phenotype Related
- Paper Title Cn
- Paper Title En
- Plant-Derived Exosomal MicroRNAs Shape the Gut Microbiota
- Bilingual Status
- semi_complete