Meta AnalysisID 7115
非法阿片类药物滥用者与健康对照者干预期间基于fMRI的功能连接差异
CRD42023418691
Does the impact of an intervention on fMRI-based functional connectivity differ between individuals who misuse illicit opioids and healthy controls?
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 7115
- Evidence Id
- 15673
- Core Evidence Id
- 15673
- Source Meta Analysis Id
- 7102
- Herb2 Meta Analysis Id
- HBMA007102
- Crd Id
- CRD42023418691
- Title
- Differences in fMRI-based functional connectivity during interventions between individuals who misuse illicit opioids and healthy controls
- Review Question
- Does the impact of an intervention on fMRI-based functional connectivity differ between individuals who misuse illicit opioids and healthy controls?
- Study Type Included
- Include= interventional trials such as RCT and observational studies, including cohort and case-control Inclusion: Adults Humans Misuse of illicit opioids defined as attachment to treatment services or formal diagnosis Studies using fMRI to measure functional connectivity Any date of publication English language publication Original research journal articles- experimental [RCTs] and observational [cohort, case-control] Peer reviewed and pre-print articles Interventions such as tasks, pharmacological, or psychological Includes healthy controls Exclusion: Severe psychiatric co-morbidity eg schizophrenia, bipolar disorder Severe physical comorbidity Neurodegenerative disease/Traumatic brain injury Non-fMRI- such as only: EEG, PET, endogenous opioid receptor, DTI No adults Only pre-clinical/animal studies Non-English language One-off opioid exposure/overdose Reviews, Conference abstracts, Dissertations, Qualitative studies- case studies, opinion pieces, letters, comments, editorials, news No full text Substance use disorder without opioid use disorder Only prescription opioid users No functional connectivity analysis No healthy controls
- Condition Being Studied
- Illicit opioid use disorder
- Participant
- Inclusion Human adults (over 18 years of age) who misuse illicit opioids (heroin or opium). Participants must have had contact with treatment services or been diagnosed with opioid use disorder/abuse/dependence to standardise level of severity of opioid misuse. Exclusion Children (under 18 years of age). Participants only misusing prescription opioids or mild opioids eg codeine. Severe physical disability. Neurodegenerative disease Traumatic brain injury Non-human animals Addiction/substance use disorder without opioid use disorder Only prescription opioid users
- Animal
- Human Disease Modelled
- Intervention
- Interventions explored may be pharmacological, sociological, clinical or cognitive tasks. Exposure is misuse of illicit opioids.
- Comparator Control
- Healthy adult controls with no personal history of opioid abuse.
- Main Outcome
- Differences in fMRI-based functional connectivity between healthy controls and people who misuse opioids Within- and between group differences in changes in functional connectivity associated with an intervention Whether within- or between group differences in functional connectivity relates to clinical or behavioural outcome measure Owing to the heterogeneity in approaches to functional connectivity analyses, the specific metric of functional connectivity reported will be the primary metric reported in each study, although multiple metrics will be extracted to facilitate the possibility of comparison across studies.
- Outcome Measure
- Additional Outcome
- Study Method
- Narrative synthesis, Systematic review
- Keyword
- Analgesics, Opioid; Humans; Magnetic Resonance Imaging
- Contact
- Anusha Prabhu [email protected]
- Organisational Affiliation
- Division of Psychiatry, Dept of Brain Sciences, Imperial College London
- Funding Source
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Hayes, A., Herlinger, K., Paterson, L., & Lingford-Hughes, A. (2020). The neurobiology of substance use and addiction: Evidence from neuroimaging and relevance to treatment. BJPsych Advances, 26(6), 367-378. doi:10.1192/bja.2020.68
- Published Protocol
- Review Type
- Language
- English
- Country
- England
- Review Stage
- Review Ongoing
- First Submission Date
- 2023-04-20
- Registration Date
- 2023-04-25
- Anticipated Start Date
- 2023-04-05
- Anticipated Completion Date
- 2023-07-01
- Title Cn
- 非法阿片类药物滥用者与健康对照者干预期间基于fMRI的功能连接差异
- Title En
- Differences in fMRI-based functional connectivity during interventions between individuals who misuse illicit opioids and healthy controls
- Bilingual Status
- complete