Meta AnalysisID 6586
中药方剂与中成药联合熊去氧胆酸治疗妊娠期肝内胆汁淤积症疗效比较：网状Meta分析
CRD42020188831
Compared with ursodeoxycholic acid alone, the effect of ursodeoxycholic acid combined with Chinese prescriptions or patent medicine for cholestasis during pregnancy. In addition, which is the best treatment option?
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Record Fields
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- Meta Analysis Id
- 6586
- Evidence Id
- 15144
- Core Evidence Id
- 15144
- Source Meta Analysis Id
- 6568
- Herb2 Meta Analysis Id
- HBMA006568
- Crd Id
- CRD42020188831
- Title
- Comparison of Chinese prescriptions and patent medicine combine with UDCA in the treatment efficacy of cholestasis during pregnancy: a network meta-analysis
- Review Question
- Compared with ursodeoxycholic acid alone, the effect of ursodeoxycholic acid combined with Chinese prescriptions or patent medicine for cholestasis during pregnancy. In addition, which is the best treatment option?
- Study Type Included
- We will include in the related clinical randomized controlled trial.
- Condition Being Studied
- Cholestasis of pregnancy is a complication occurring during pregnancy, mainly in the middle and later stages of pregnancy.The disease can lead to premature delivery, amniotic fluid pollution, neonatal asphyxia, neonatal pneumonia and a series of adverse perinatal outcomes.At the same time, studies have found that women with a history of ICP have a higher risk of cholelithiasis, cholecystitis, hypothyroidism, pancreatic disease and digestive disease
- Participant
- Inclusion: 1.The patient has itchy skin as the main symptom during pregnancy. 2.The level of related indicators including ALT (alanine aminotransferase), AST (aspartate transaminase), TBA ( total biliary acid) increased. Exclusion: Other liver and gallbladder diseases such as viral hepatitis.
- Animal
- Human Disease Modelled
- Intervention
- Accoding to the treatment option， there are 6 interbentions including B: yinzhihuang oral liquid + UDCA; C: salvia injection + UDCA; D: yinchenhao decoction (yinchen > 15g, zhizi > 9g, dahunag > 5g) + UDCA; E: the change of yinchenhao decoction 1 (yinchen > 15g, zhizi < 9g, dahunag > 5g) + UDCA; F: the change of yinchenhao decoction 2 (yinchen > 15g, zhizi > 9g, dahunag < 5g) + UDCA; G: the change of yinchenhao decoction 3 (yinchen > 15g, zhizi < 9g, dahunag < 5g) + UDCA; H: other Traditional Chinese Medicine prescriptions (yinchen < 15g, zhizi < 9g, dahunag < 5g) + UDCA.
- Comparator Control
- The treatment option A: using UDCA (ursodeoxycholic acid) alone was as the control group.
- Main Outcome
- Main outcome include in pruritus score which is based on the standards set by Ribalta and the level of ALT (alanine aminotransferase), AST (aspartate transaminase), TBA ( total biliary acid). Measures of effect Mean differences is our main effect measure.
- Outcome Measure
- Additional Outcome
- None. Measures of effect None.
- Study Method
- Meta-analysis, Systematic review
- Keyword
- China; Cholestasis, Intrahepatic; Female; Humans; Network Meta-Analysis; Nonprescription Drugs; Pregnancy; Prescriptions; Treatment Outcome
- Contact
- Yin Xiao Jiang [email protected]
- Organisational Affiliation
- Chengdu University of Traditional Chinese Medicine
- Funding Source
- Sichuan Science and Technology Program (2019YJ0492)
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2020-08-09
- Registration Date
- 2020-09-09
- Anticipated Start Date
- 2020-08-09
- Anticipated Completion Date
- 2020-09-10
- Title Cn
- 中药方剂与中成药联合熊去氧胆酸治疗妊娠期肝内胆汁淤积症疗效比较：网状Meta分析
- Title En
- Comparison of Chinese prescriptions and patent medicine combine with UDCA in the treatment efficacy of cholestasis during pregnancy: a network meta-analysis
- Bilingual Status
- complete