Meta AnalysisID 6583
中药茵栀黄口服液联合光疗治疗新生儿黄疸：随机临床试验的系统评价
CRD42016037691
To systematically evaluate the effectiveness and safety of Chinese herbal medicine Yinzhihuang oral liquid combined with phototherapy for treating neonatal jaundice.
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Record Fields
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- Meta Analysis Id
- 6583
- Evidence Id
- 15141
- Core Evidence Id
- 15141
- Source Meta Analysis Id
- 6565
- Herb2 Meta Analysis Id
- HBMA006565
- Crd Id
- CRD42016037691
- Title
- Chinese herbal medicine Yinzhihuang oral liquid combined with phototherapy for treating neonatal jaundice: a systematic review of randomized clinical trials
- Review Question
- To systematically evaluate the effectiveness and safety of Chinese herbal medicine Yinzhihuang oral liquid combined with phototherapy for treating neonatal jaundice.
- Study Type Included
- Randomized clinical trials (RCT) will be included regardless of blinding, publication type or language.
- Condition Being Studied
- Neonatal jaundice is not an uncommon occurrence for newborn babies in pediatric department, in which the main performance is yellowish pigmentation of skin, mucous membranes or organs. It is estimated that, worldwide, severe hyperbilirubinaemia affects at least 481,000 term or near term newborn babies annually, of whom 114,000 die and more than 63,000 survive with moderate or severe disability. Bilirubin is the main metabolites of iron porphyrin compounds in the body and has neurovirulence. Without control it can progress to hyperbilirubinemia, which can cause bilirubin encephalopathy, or even be life-threatening. Due to the individual diversity, it is difficult to define an acceptable distinction between physiological and pathological jaundice. Chinese herbal medicine Yinzhihuang oral liquid, original recorded in the traditional Chinese medicine (TCM) classical Cold Damage and Golden Chamber, was approved by the Chinese Food and Drug Administration for treatment of jaundice. It is mainly composed of extraction of Herba Artemisiae Scopariae, Fructus Gardeniae, Radix Scutellariae and a small amount of Flos Lonicerae Japonicae. The oral liquid has the function of removing dampness in Chinese medicine theory so as to eliminate jaundice.
- Participant
- Infants from term labor, within 28 days from birth, who had a clinical feature of jaundice in sclera, body or limbs and so on, regardless of physiologic or pathologic nature, will be included in this systematic review.
- Animal
- Human Disease Modelled
- Intervention
- Chinese herbal medicine Yinzhihuang oral liquid combined with phototherapy (blue light) will be included regardless of dosage or treatment duration.
- Comparator Control
- Phototherapy (blue light) alone will be included in this systematic review.
- Main Outcome
- Failure of jaundice defecation, which is defined as the rate of participants without significant yellow fading in skin and/or sclera after treatment, or without serum decline in total bilirubin. Serious adverse events defined as any result that reported death, life-threatening, hospitalization, disability or permanent damage after therapy.
- Outcome Measure
- Additional Outcome
- Time of defecation, defined as the duration from beginning of intervention to jaundice fading. Serum total bilirubin level, which was tested by quantitative method. Non-serious adverse event. Any adverse events occurred after Yinzhihuang oral liquid given or control therapy was recorded, including vomiting, diarrhea or any medical event which may caused by the intervention.
- Study Method
- Keyword
- Complementary Therapies; Drugs, Chinese Herbal; Humans; Infant, Newborn; Jaundice, Neonatal; Phototherapy
- Contact
- Dr Wu [email protected]
- Organisational Affiliation
- Centre for Evidence-Based Chinese Medicine, Beijing University of Chinese Medicine
- Funding Source
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- Registration Date
- 2016-04-21
- Anticipated Start Date
- 2016-01-29
- Anticipated Completion Date
- 2016-05-31
- Title Cn
- 中药茵栀黄口服液联合光疗治疗新生儿黄疸：随机临床试验的系统评价
- Title En
- Chinese herbal medicine Yinzhihuang oral liquid combined with phototherapy for treating neonatal jaundice: a systematic review of randomized clinical trials
- Bilingual Status
- complete