Meta AnalysisID 6095
复方丹参滴丸对糖尿病周围神经病变的疗效：随机对照试验的系统评价与Meta分析
CRD42020220760
Diabetic peripheral neuropathy (DPN) is one of the most common neurological complications of diabetes mellitus, which brings diabetic patients with much physical pain and their living inconvenience. At present, although
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Record Fields
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- Meta Analysis Id
- 6095
- Evidence Id
- 14653
- Core Evidence Id
- 14653
- Source Meta Analysis Id
- 6077
- Herb2 Meta Analysis Id
- HBMA006077
- Crd Id
- CRD42020220760
- Title
- Efficacy of Compound Danshen Dropping Pills on Diabetic Peripheral Neuropathy: A Systematic Review and Meta-analysis of Randomized Controlled Trials
- Review Question
- Diabetic peripheral neuropathy (DPN) is one of the most common neurological complications of diabetes mellitus, which brings diabetic patients with much physical pain and their living inconvenience. At present, although there are many clinical treatments of DPN by Compound Danshen dripping pills (CDDP), there is no certain meta-analysis to ensure the safety and positive effectiveness of those treatments. The purpose of this study was to evaluate the clinical features of CDDP in treating DPN.
- Study Type Included
- RCT
- Condition Being Studied
- As a kind of progressive disease, diabetic peripheral neuropathy (DPN) could cause impairment to the sensory movement of peripheral nervous system, with autonomic nervous system involvement and motor function which is the most common complication of diabetes.For this kind of neuropathy, the symptoms or clinical signs start with the foot, involve more and more proximal parts of the lower limbs, and end up affecting the distal parts of the upper limbs. Then, the shorter sensory axon is involved, causing more neuropathy in the proximal and anterior trunk of the limb, for which it is called the dying back syndrome.
- Participant
- A total of 1924 participants were involved in this RCT study.Firstly, it is randomized controlled clinical trial (RCT) Secondly, all cases involved met the diagnostic criteria for diabetes published by the World Health Organization in 2020. Thirdly, the patients suffered from diabetic neuropathy, such as pain numbness in the feet, weakness, burning sensation and other limb dysfunction, or physical examination of the Achilles tendon and knee reflex weakened, or disappeared or the nerve conduction speed is lower than normal. Fourthly, the age and follow-up time of patients are unrestricted, with the publication language limited to Chinese and English. The literature with the following characteristics is excluded from this meta-analysis. Firstly, it does not include RCT or repeated publications. Secondly, it is related to animal experiments or cell research. Thirdly, it is a review of articles. Fourthly, it applies other traditional Chinese medicine (TCM) in the control groups. Fifthly, DPN is not referred to in the text. Sixthly, CDDP is applied in the control group. Lastly, there is no complete results data.
- Animal
- Human Disease Modelled
- Intervention
- Compound Danshen Dripping Pills 15 pills(Tianjin Tianshili Pharmaceutical Co., Ltd,.oral, three times per day)
- Comparator Control
- Basic treatment of diabetes (drugs, exercise, diet control), patients with hypertension, hyperlipidemia, appropriate antihypertensive, lipid-lowering therapy.
- Main Outcome
- Sensory nerve conduction velocity (SCV), Motor nerve conduction velocity (MCV) Measures of effect relative risks, odds ratios
- Outcome Measure
- Additional Outcome
- None Measures of effect None
- Study Method
- Meta-analysis, Systematic review
- Keyword
- Diabetes Mellitus; Diabetic Neuropathies; Drugs, Chinese Herbal; Humans; Randomized Controlled Trials as Topic; Salvia miltiorrhiza
- Contact
- Xinchen Wang [email protected]
- Organisational Affiliation
- School of Food and Pharmaceutical Engineering, Zhaoqing College
- Funding Source
- Guangdong Province University Colleges and Universities Special Innovation Project (2019KTSCX023) Jiao-tai-wan molecular mechanism for improving insulin resistance through circadian rhythm mediated by the SCN-HPA-GC circadian clock pathway. Grant number(s) <span style=font-size: 14px>State the funder, grant or award number and the date of award</span> Guangdong Province University Colleges and Universities Special Innovation Project (2019KTSCX023) Jiao-tai-wan molecular mechanism for improving insulin resistance through circadian rhythm mediated by the SCN-HPA-GC circadian clock pathway.
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2020-11-14
- Registration Date
- 2020-12-14
- Anticipated Start Date
- 2020-08-02
- Anticipated Completion Date
- 2020-12-25
- Title Cn
- 复方丹参滴丸对糖尿病周围神经病变的疗效：随机对照试验的系统评价与Meta分析
- Title En
- Efficacy of Compound Danshen Dropping Pills on Diabetic Peripheral Neuropathy: A Systematic Review and Meta-analysis of Randomized Controlled Trials
- Bilingual Status
- complete