Meta AnalysisID 6066
中医药治疗多囊卵巢综合征女性不孕的网状Meta分析
CRD42022375101
This network meta-analysis was developed to compare the efficacy of co-treatment with twelve classical prescriptions and Chinese patent medicines against western medicine monotherapy in the treatment of PCOS.
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Record Fields
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- Meta Analysis Id
- 6066
- Evidence Id
- 14624
- Core Evidence Id
- 14624
- Source Meta Analysis Id
- 6049
- Herb2 Meta Analysis Id
- HBMA006049
- Crd Id
- CRD42022375101
- Title
- A network meta-analysis of Traditional Chinese Medicine in the treatment of infertility in women with polycystic ovary syndrome
- Review Question
- This network meta-analysis was developed to compare the efficacy of co-treatment with twelve classical prescriptions and Chinese patent medicines against western medicine monotherapy in the treatment of PCOS.
- Study Type Included
- Randomized clinical trials will be include dirrespective of blinding, publication status or language.
- Condition Being Studied
- Polycystic ovary syndrome (PCOS) is an endocrine disease that affects gynecological health, clinical manifestations include obesity, infrequent menstruation, anovulation, hirsutism, acne, infertility and other symptoms.Treatment of infertility in women with PCOS remains a big challenge for clinicians.Studies have shown that traditional Chinese medicine has a significant effect on the treatment of polycystic ovary syndrome infertility, but the types of drugs are complex, and there is a lack of comparison between the effects of different drugs.Our research facilitates better clinical guidance.
- Participant
- We used the following inclusion criteria: 1)Participants: patients with ovulatory disorders (e.g., ovulatory infertility and polycystic ovary syndrome) requiring fertility treatment 2) Intervention: any kind of Chinese patent medicine or classical prescriptions combined with western medicine 3) Comparison: western medicine alone 4) Outcomes: change in ovulation rate, pregnancy rate, and endometrial thickness after the treatment 5) Study design: randomized clinical trial (RCT) 6) Language: English or Chinese studies We excluded studies based on the following criteria: 1) studies not including the required outcomes 2) repeated publications 3) self-control studies and non-RCTs 4) preclinical studies, systematic reviews, case reports, and meta-analyses 5) protocols, unpublished studies, or duplicate studies 6) studies based on a research design with obvious defects or suspected fraud
- Animal
- Human Disease Modelled
- Intervention
- Chinese patent medicine and classical prescriptions are the main interventions.In the included studies, the experimental groups received a combination therapy, which included TCM and western medicine; the control groups were given western medicine alone.
- Comparator Control
- e.g., the experimental groups received a combination therapy, which included Ding Kun Dan and letrozole, the control groups were given letrozole alone.
- Main Outcome
- Treatment outcome indicators included: cycle ovulation rate, pregnancy rate, and endometrial thickness after the treatment. Measures of effect The ovulation and pregnancy rates are dichotomous variables,and the odds ratio (OR) was used to indicate the size of the effect.The endometrial thickness on the day of follicular maturity is a continuous variable, and the mean difference (MD) was used to indicate the quantity of the effect, and the 95% confidence interval (95% CI) of the OR and the MD were calculated.
- Outcome Measure
- Additional Outcome
- Luteinizing hormone (LH) to follicle-stimulating hormone (FSH) ratio, body mass index (BMI), total effective rate of symptom treatment, LH level, FSH level and safety evaluation. Measures of effect Heterogeneity was quantitatively determined using I², with I²< 50% and p > 0.1 indicating no statistical heterogeneity. A fixed-effect model was used for meta-analysis. If statistical heterogeneity was found between the studies, subgroup and other methods were used to find the source of the heterogeneity, and if it could not be found, the random-effect model was used for meta-analysis.
- Study Method
- Network meta-analysis, Systematic review
- Keyword
- China; Female; Humans; Infertility; Medicine, Chinese Traditional; Network Meta-Analysis; Nonprescription Drugs; Polycystic Ovary Syndrome; Prescriptions
- Contact
- Li kun Liu [email protected]
- Organisational Affiliation
- The Second Clinical Medical College, Beijing University of Chinese Medicine
- Funding Source
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Chinese patent medicine; Classical Prescriptions; ovulation disorder; polycystic ovary syndrome; meta-analysis
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2022-11-11
- Registration Date
- 2022-11-22
- Anticipated Start Date
- 2022-10-15
- Anticipated Completion Date
- 2022-12-31
- Title Cn
- 中医药治疗多囊卵巢综合征女性不孕的网状Meta分析
- Title En
- A network meta-analysis of Traditional Chinese Medicine in the treatment of infertility in women with polycystic ovary syndrome
- Bilingual Status
- complete