Meta AnalysisID 6065
定坤丹联合促排卵药物治疗排卵障碍性不孕的疗效与安全性：一项Meta分析
CRD42022315316
To systematically evaluate the efficacy and safety of Dingkun Dan combined with ovulation-stimulating drugs for ovulatory dysfunctional infertility.
Relationship Network
Interactive first-hop connections across herbs, ingredients, formulas, targets, diseases, symptoms, syndromes, evidence, and monographs.
Click a node to open it in a new tab
Formula: 1Meta-analysis: 1Links: 1
Arranging relationship network...
Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 6065
- Evidence Id
- 14623
- Core Evidence Id
- 14623
- Source Meta Analysis Id
- 6048
- Herb2 Meta Analysis Id
- HBMA006048
- Crd Id
- CRD42022315316
- Title
- A meta-analysis: efficacy and safety of Dingkun Dan combined with ovulation-stimulating drugs for ovulatory dysfunctional infertility
- Review Question
- To systematically evaluate the efficacy and safety of Dingkun Dan combined with ovulation-stimulating drugs for ovulatory dysfunctional infertility.
- Study Type Included
- Randomized controlled trial (RCT).
- Condition Being Studied
- Infertility is a reproductive disorder caused by a variety of causes. The World Health Organization defines infertility as infertility when both spouses have regular sexual life without contraceptive measures for at least 12 months without pregnancy.It has been reported in the literature that about 8-12% of couples worldwide are infertile.The factors that cause infertility include male and female factors. Among the female infertility factors, ovulation disorder accounts for about 52.12%.Ovulatory infertility is a common endocrine disorder in gynecology. The lesions of the hypothalamus, pituitary, and ovarian reproductive axis can lead to ovulation disorders in women.Ovulation stimulating drugs are often used to treat ovulatory infertility clinically, but there is a phenomenon of high output and low pregnancy when ovulation stimulating drugs are used, which will also lead to complications such as ovarian hyperstimulation syndrome (OHSS), multiple pregnancy, ectopic pregnancy and so on. And long-term use of ovulation drugs may also increase the risk of breast cancer and thyroid cancer
- Participant
- Participants:①met the diagnostic criteria set out in the 2019《diagnostic guidelines for infertility》[8]: every couple who had regular sex for at least 12 months and did not take contraceptive measures without pregnancy.②Exclude infertility caused by men and other non ovulatory factors.
- Animal
- Human Disease Modelled
- Intervention
- observation group:Dingkun dan combined with ovulation promoting drugs;
- Comparator Control
- Control group: single use of the same kind of ovulation promoting drugs.
- Main Outcome
- Outcome measures:①ovulation rate;②Clinical pregnancy rate;③Biochemical pregnancy rate;④Endometrial thickness on ovulation day (mm);⑤Incidence of adverse reactions. Measures of effect The relative risk ratio (RR) or risk difference (RD) is used as the effect quantity for binary variable, and the mean difference (MD) is used as the effect quantity for the continuity variable, providing its 95% CI.
- Outcome Measure
- Additional Outcome
- Study Method
- Meta-analysis, Systematic review
- Keyword
- Anovulation; Female; Humans; Infertility, Female
- Contact
- Maoya Li [email protected]
- Organisational Affiliation
- Chengdu University of TCM
- Funding Source
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Completed not published
- First Submission Date
- 2022-03-07
- Registration Date
- 2022-04-07
- Anticipated Start Date
- 2021-11-01
- Anticipated Completion Date
- 2022-09-30
- Title Cn
- 定坤丹联合促排卵药物治疗排卵障碍性不孕的疗效与安全性：一项Meta分析
- Title En
- A meta-analysis: efficacy and safety of Dingkun Dan combined with ovulation-stimulating drugs for ovulatory dysfunctional infertility
- Bilingual Status
- complete