Meta AnalysisID 6055
中药灯盏细辛注射液治疗急性缺血性脑卒中：随机对照试验的系统评价和Meta分析
CRD42016038413
Is Chinese herbal medicine Dengzhan Xixin injection effective and safe for treatment of acute ischemic stroke?
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Record Fields
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- Meta Analysis Id
- 6055
- Evidence Id
- 14613
- Core Evidence Id
- 14613
- Source Meta Analysis Id
- 6038
- Herb2 Meta Analysis Id
- HBMA006038
- Crd Id
- CRD42016038413
- Title
- Chinese herbal medicine Dengzhan Xixin injection for acute ischemic stroke: a systematic review and meta-analysis of randomized controlled trials
- Review Question
- Is Chinese herbal medicine Dengzhan Xixin injection effective and safe for treatment of acute ischemic stroke?
- Study Type Included
- We included only randomized controlled trials (RCTs) studying Dengzhanxixin injection for acute ischemic stroke. Quasi-RCTs which allocated the patients by dates of birth, or day of the week, alternation, the sequence of admission, case record numbers were excluded. Both published and unpublished trials were included. We applied no restrictions regarding the language of publication and combined multiple publications reporting the same trial into one study.
- Condition Being Studied
- Stroke is a neurological impairment due to an acute focal injury of the central nervous system (CNS) by a vascular cause, including cerebral infarction, intracerebral hemorrhage (ICH), and subarachnoid hemorrhage (SAH). It often leads to physical disability and death. According to the World Health Organization, stroke has become the second most common cause of death across the world. Acute ischemic stroke or cerebral infarction is the most common type of stroke, accounting for 60 to 80 percent of all strokes, so we focused on acute ischemic stroke in this research.
- Participant
- Participants who were diagnosed with acute ischemic stroke by computerized tomography (CT) or magnetic resonance imaging (MRI) scan regardless of their sex, age or race were eligible.
- Animal
- Human Disease Modelled
- Intervention
- Chinese herbal medicine Dengzhan Xixin injection (extraction of Erigeron breviscapus) was regarded as the intervention, regardless of its dosage, duration.
- Comparator Control
- Placebo, or a Western therapy. We also allowed a co-intervention (conventional western medicine) if applied in all arms.
- Main Outcome
- (1) Death (2) Disability or dependence defined as Barthel Index (BI) scores <60 or the modified Rankin scale (MRS) scores >3 (People who are severly disabled and have to depend on help from other people for their activities of daily living). (3) Serious adverse events: fatal, life threatening, requiring change of treatment regimen. Measures of effect at the end of the scheduled treatment or follow up period
- Outcome Measure
- Additional Outcome
- (4) Changes of neurological deficit after treatment. The measures can focus on specific impairment (e.g., motor deficit or cognitive impairment) or global neurological deficit (e.g., the National Institutes of Health Stroke Scale (NIHSS); European Stroke Scale (ESS); the Neurological Function Deficit Score (NFDS), a nationwide accepted scoring system recommended at the Fourth National Cerebrovascular Diseases Conference in China[15]; or the Scandinavian Stroke Scale (SSS)). (5) Quality of life if assessed in the included trials by validated scale without limitations on the specific scales used. (6) Treatment failure, defined as reduction of NFDS less than 18% or death according to the nationally approved criteria in China. (7) Non-serious adverse event specifically associated with Dengzhan Xixin injection such as allergic reaction, palpitation, flushing, etc. Measures of effect At the end of the scheduled treatment or follow up period
- Study Method
- Intervention, Meta-analysis, Systematic review
- Keyword
- Complementary Therapies; Drugs, Chinese Herbal; Humans; Injections; Randomized Controlled Trials as Topic; Stroke
- Contact
- Organisational Affiliation
- Funding Source
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- Review Stage
- First Submission Date
- Registration Date
- Anticipated Start Date
- Anticipated Completion Date
- Title Cn
- 中药灯盏细辛注射液治疗急性缺血性脑卒中：随机对照试验的系统评价和Meta分析
- Title En
- Chinese herbal medicine Dengzhan Xixin injection for acute ischemic stroke: a systematic review and meta-analysis of randomized controlled trials
- Bilingual Status
- complete