Meta AnalysisID 601
鸦片消耗与人类癌症：系统评价与Meta分析
CRD42021236030
Does opium consumption [smoked or ingested] increase the risk of either incidence or mortality of cancer in adults?
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 601
- Evidence Id
- 9159
- Core Evidence Id
- 9159
- Source Meta Analysis Id
- 578
- Herb2 Meta Analysis Id
- HBMA000578
- Crd Id
- CRD42021236030
- Title
- Opium consumption and cancer in humans: a systematic review and meta-analysis
- Review Question
- Does opium consumption [smoked or ingested] increase the risk of either incidence or mortality of cancer in adults?
- Study Type Included
- Cohort and case-control studies.
- Condition Being Studied
- We will include as an outcome five different cancers types, namely, cancers in the larynx, lung, bladder, oesophagus and stomach. The outcomes of main interest are cancers of larynx, lung, and bladder, which are not the subject of any known in-progress meta-analyses; however, because there are new cohort studies examining cancers of oesophagus and stomach (in addition to the sites of primary interest), we will also incorporate analyses of these cancer outcomes.
- Participant
- The systematic review and meta-analysis will include studies of humans exposed environmentally to minimally processed opium via consumption. These studies will be of either (i) populations (cohorts) whose opium consumption patterns are examined and cancer experience followed prospectively, with cancer rates compared among exposed and unexposed and by exposure category; or (ii) case-control studies of populations (e.g., patients) diagnosed with or deceased from cancer for whom previous exposure to opium consumption has been estimated and compared with the opium exposure of persons who did not have cancer. The evaluation will include only populations exposed to minimally processed forms of opium (e.g., raw opium, opium dross, opium sap). Populations exposed only to other opiates (e.g., heroin, codeine) or opioids (e.g. fentanyl) will not be included.
- Animal
- Human Disease Modelled
- Intervention
- Individual or group levels (intensity and duration) of opium smoked or ingested, measured either through questionnaire interviewing or using biological metabolites, are the main exposure of interest. Variables may be categorized as “never” vs “ever” exposed to opium consumption, or by levels of duration or intensity of opium consumption, or to cumulative opium (e.g., nokhod-years).
- Comparator Control
- In cohort studies the comparison group will be represented by the individual non-exposed to opium consumption at the baseline of study; and control group in case-control studies are those patients without cancer diagnosis or cancer death.
- Main Outcome
- Diagnosis and death of any malignant neoplasm in humans. Measures of effect Relative risks, odds ratios
- Outcome Measure
- Additional Outcome
- None Measures of effect Not applicable
- Study Method
- Epidemiologic, Meta-analysis, Systematic review
- Keyword
- Humans; Neoplasms; Opium
- Contact
- Organisational Affiliation
- Funding Source
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- Review Stage
- First Submission Date
- Registration Date
- Anticipated Start Date
- Anticipated Completion Date
- Title Cn
- 鸦片消耗与人类癌症：系统评价与Meta分析
- Title En
- Opium consumption and cancer in humans: a systematic review and meta-analysis
- Bilingual Status
- complete