Meta AnalysisID 565
基于川芎的中药疗法治疗紫杉烷类药物引起的外周神经毒性：一项系统评价与Meta分析
CRD42020193978
In view of the lack of systematic assessment on Rhizoma Chuanxiong based-Chinese medicine therapy for TIPN, this study was to evaluate the effectiveness and safety of this therapy on the prevention and treatment of TIPN
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 565
- Evidence Id
- 9123
- Core Evidence Id
- 9123
- Source Meta Analysis Id
- 544
- Herb2 Meta Analysis Id
- HBMA000544
- Crd Id
- CRD42020193978
- Title
- Rhizoma Chuanxiong based-Chinese Medicine Therapy for Taxanes-Induced Peripheral Neurotoxicity：A Systemic Review and Meta-Analysis
- Review Question
- In view of the lack of systematic assessment on Rhizoma Chuanxiong based-Chinese medicine therapy for TIPN, this study was to evaluate the effectiveness and safety of this therapy on the prevention and treatment of TIPN through systematic reviews and meta-analysis on the current available studies.
- Study Type Included
- Type of study was randomized controlled trial (RCT). English and Chinese were applied as language restriction.
- Condition Being Studied
- Taxanes-derived agents such as paclitaxel and docetaxel are chemotherapy drugs widely applied in many types of cancers such as non-small cell lung cancer, metastatic breast cancer and ovarian cancer, and usually used as the first-line treatment. However, Peripheral neurotoxicity is the dose-limiting adverse effect of taxanes, limits its clinical administration, often manifested as painful neuropathy, compromise the quality of the survivorship, and it is sometimes irreversible.The incidence of taxanes-induced peripheral neurotoxicity (TIPN) is high, ranging from 57%–83% overall and with severity in 2%–33% of patients treated with paclitaxel , 11%–64% overall and with severity 3%–14% of patients treated with docetaxel. Moreover, published neuropathy incidence and severity also seem greater when patient-reported outcome measures are considered in TIPN assessment.
- Participant
- patients will receive or have received taxanes containing chemotherapy regimens; age, race, nationality, and sex were not limited.
- Animal
- Human Disease Modelled
- Intervention
- The treatment groups received oral or external Chinese herbal medicine treatment which contains Rhizoma Chuanxiong.
- Comparator Control
- The controlled groups received conventional treatment or observation.
- Main Outcome
- (1) effective rate of TIPN;(2) the incidence of TIPN; Measures of effect The total improvement of TIPN and the incidence of TIPN were measured and presented with relative risk (risk ratio, RR) and 95% corresponding confidential intervals (CI).
- Outcome Measure
- Additional Outcome
- (3) motor nerve conduction velocity (MNCV);(4) sensory nerve conduction velocity (SNCV). Measures of effect MNCV and SNCV were presented as mean difference (MD), with 95% CI.
- Study Method
- Meta-analysis, Systematic review
- Keyword
- Humans
- Contact
- Lingling Sun [email protected]
- Organisational Affiliation
- The First Affiliated Hospital of Guangzhou University of Chinese Medicine
- Funding Source
- National Natural Science Foundation of China
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2020-06-24
- Registration Date
- 2020-07-25
- Anticipated Start Date
- 2020-05-01
- Anticipated Completion Date
- 2020-09-30
- Title Cn
- 基于川芎的中药疗法治疗紫杉烷类药物引起的外周神经毒性：一项系统评价与Meta分析
- Title En
- Rhizoma Chuanxiong based-Chinese Medicine Therapy for Taxanes-Induced Peripheral Neurotoxicity：A Systemic Review and Meta-Analysis
- Bilingual Status
- complete