Meta AnalysisID 557
石榴与氯己定对儿童及年轻人牙菌斑和牙龈炎的疗效比较：一项系统评价
CRD42021150616
Is Punica Granautum more effective in reducing plaque and gingivitis as compared to chlorhexidine among children and young adults?
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Record Fields
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- Meta Analysis Id
- 557
- Evidence Id
- 9115
- Core Evidence Id
- 9115
- Source Meta Analysis Id
- 536
- Herb2 Meta Analysis Id
- HBMA000536
- Crd Id
- CRD42021150616
- Title
- Efficacy of punica granatum against dental plaque and gingivitis as compared to chlorhexidine among children and young adults: a systematic review
- Review Question
- Is Punica Granautum more effective in reducing plaque and gingivitis as compared to chlorhexidine among children and young adults?
- Study Type Included
- We will include randomised controlled trials in which Punica Granatum mouthrinse was delivered to test anti plaque and anti gingivitis efficacy as compared to chlorhexidine mouthwash.
- Condition Being Studied
- Gingivitis is a chronic inflammatory process limited to the gingiva, characterized by the accumulation of plaque biofilm at or below the gingival margin which is then associated with inappropriate and destructive host inflammatory immune response. Plaque is a naturally occuring sticky film containing bacteria, that builds up on teeth and causes the inflammation of surrounding gum tissues. Chemical therapeutic agents play a crucial role in controlling plaque. Among these agents, chlorhexidine is widely used and considered as the gold standard. However, chlorhexidine has several side effects such as staining and taste alteration. Thus for better oral health, there is a need of alternative economical products with equal efficacy and less side effects. From last few decades, natural products have expanded globally because of increased consumer awareness and fewer side effects i.e calendulla, Aloe-vera, Punica Granatum. In this review, we would like to evaluate the efficacy of Punica Granatum mouthrinse in reducing plaque and gingivitis.
- Participant
- Inclusion criteria: Children and young adults will be included. Minimum 20 sound, natural teeth (non-carious). Plaque index (Turesky-Gilmore Modification Of Quigley Hein Plaque Index) score of at least 1.5. Gingival index (Loe and Silness) score of at least 1.0. Subjects willing to give informed consent and follow the schedule. Subjects with good systemic health. Exclusion Criteria: Subjects with grossly decayed teeth, full crown or extensively restored teeth or undergoing orthodontic treatment. Subjects with any intra oral soft tissue pathology. Subjects allergic to punica granatum, subjects undergoing antibiotic treatment or had it in last one month. Subjects using antimicrobial mouthrinse. Subjects with smoking habits. Subjects having history of periodontal treatment within last 3 months.
- Animal
- Human Disease Modelled
- Intervention
- Punica Granatum mouthrinse is the intervention of interest. It is commonly known as pomegranate which belongs to family punicaceae. It contains polyphenols, tannins, ellagic acid and anthocyanins. It exhibits antibacterial, antifungal, anti-oxidants, anti-cariogenic and anti-inflammatory properties. Pomegranate peel mouthrinse has shown activity against a variety of bacteria seen mostly in dental plaque. It inhibits a common species of Streptococcus, preventing it from producing chemicals that create favorable conditions for fungi and other microorganisms to thrive. Plaque may involve a variety of organisms that together colonize the surface of the teeth. Pomegranate fights organisms‟ ability to adhere by interfering with production of the very chemicals the bacteria use as glue. Its extract suppresses the ability of these microorganisms to adhere to the surface of the tooth. Pomegranate components have properties that could reduce the risk of gingivitis and promote overall oral health.
- Comparator Control
- A commercially available chlorhexidine mouthwash is the comparator intervention.
- Main Outcome
- Efficacy of Punica Granatum against plaque and gingivitis i.e reduction in plaque and gingival index scores after using Punica granatum mouthrinse at different time intervals Measures of effect The standardized mean difference in Reduction of plaque and gingival score
- Outcome Measure
- Additional Outcome
- Not applicable Measures of effect Not applicable
- Study Method
- Intervention, Narrative synthesis, Prevention, Systematic review
- Keyword
- Child; Chlorhexidine; Dental Plaque; Gingivitis; Humans; Mouthwashes; Pomegranate; Young Adult
- Contact
- Swati Singroha [email protected]
- Organisational Affiliation
- Sudha Rustagi College of Dental Sciences and Research
- Funding Source
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- India
- Review Stage
- Review Ongoing
- First Submission Date
- 2019-10-04
- Registration Date
- 2021-01-13
- Anticipated Start Date
- 2021-01-01
- Anticipated Completion Date
- 2021-04-15
- Title Cn
- 石榴与氯己定对儿童及年轻人牙菌斑和牙龈炎的疗效比较：一项系统评价
- Title En
- Efficacy of punica granatum against dental plaque and gingivitis as compared to chlorhexidine among children and young adults: a systematic review
- Bilingual Status
- complete