Meta AnalysisID 551
水蛭制剂治疗肾病综合征伴高凝状态和高脂血症：系统评价与Meta分析
CRD42022326897
What is the effectiveness of leech preparations on nephrotic syndrome patients with hypercoagulable and hyperlipidemia?
Relationship Network
Interactive first-hop connections across herbs, ingredients, formulas, targets, diseases, symptoms, syndromes, evidence, and monographs.
Click a node to open it in a new tab
Herb: 1Meta-analysis: 1Links: 1
Arranging relationship network...
Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 551
- Evidence Id
- 9109
- Core Evidence Id
- 9109
- Source Meta Analysis Id
- 530
- Herb2 Meta Analysis Id
- HBMA000530
- Crd Id
- CRD42022326897
- Title
- Leech Preparations in the Treatment of Nephrotic Syndrome with Hypercoagulability and Hyperlipidemia: A Systematic Review and Meta-Analyses
- Review Question
- What is the effectiveness of leech preparations on nephrotic syndrome patients with hypercoagulable and hyperlipidemia?
- Study Type Included
- Inclusion Criteria: The study is a randomized controlled trial (RCT). Exclusion Criteria: Non-RCT trials.
- Condition Being Studied
- Nephrotic syndrome is a clinical syndrome of hyperlipidemia, edema, and various complications due to increased glomerular filtration membrane permeability leading to massive proteinuria and hypoalbuminemia. Among them, hypercoagulability and hyperlipidemia are typical characteristics of NS. Due to platelet activation, enhanced erythrocyte aggregation, and imbalance between procoagulant and anticoagulant factors, blood hypercoagulability is prone to occur. Hypoproteinemia promotes increased lipoprotein synthesis in the liver, leading to hyperlipidemia. Hyperlipidemia can make the blood thicker and promote thrombosis. Leech contains hirudin, a natural thrombin-specific inhibitor that can act as an anticoagulant, lower blood lipids, anti-inflammatory, anti-fibrosis, improve renal function, and protect the kidneys.
- Participant
- We will include systematic reviews of randomised controlled trials on human subjects diagnosed with Nephrotic syndrome.
- Animal
- Human Disease Modelled
- Intervention
- Inclusion Criteria: Leech preparations. (leech powder, leech injection, pulse blood sampling, and other symptomatic treatments) Exclusion Criteria: Use other Chinese medicine treatments besides leech preparations.
- Comparator Control
- Inclusion Criteria: Routine treatment (glucocorticoids, immunosuppressive agents, anticoagulation, and other symptomatic treatments) Exclusion Criteria: Use other Chinese medicine treatments.
- Main Outcome
- We will be evaluating improvement or decline from baseline in quantitative and objective measures. Main outcome: Reducing 24h urine total protein, total cholesterol, triglyceride, fibrinogen, increasing plasma albumin. Measures of effect Mean Difference
- Outcome Measure
- Additional Outcome
- Prolonging activated partial thromboplastin time Measures of effect Mean Difference
- Study Method
- Systematic review
- Keyword
- Humans; Hyperlipidemias; Nephrotic Syndrome; Thrombophilia
- Contact
- Dong liwen [email protected]
- Organisational Affiliation
- Henan University of Traditional Chinese Medicine
- Funding Source
- Supported by the Natural Science Foundation of Henan Province Grant number(s) <span style=font-size: 14px>State the funder, grant or award number and the date of award</span> Supported by the Natural Science Foundation of Henan Province（182300410346）
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2022-04-19
- Registration Date
- 2022-05-10
- Anticipated Start Date
- 2022-01-15
- Anticipated Completion Date
- 2022-05-19
- Title Cn
- 水蛭制剂治疗肾病综合征伴高凝状态和高脂血症：系统评价与Meta分析
- Title En
- Leech Preparations in the Treatment of Nephrotic Syndrome with Hypercoagulability and Hyperlipidemia: A Systematic Review and Meta-Analyses
- Bilingual Status
- complete