Meta AnalysisID 548

水蛭治疗骨关节炎 [Cochrane方案]

CRD42015017418

To assess the benefits and harms of leeches compared with placebo, no intervention or any other active treatment in people with osteoarthritis.

Back to Browse

Relationship Network

Interactive first-hop connections across herbs, ingredients, formulas, targets, diseases, symptoms, syndromes, evidence, and monographs.

Click a node to open it in a new tab

Herb: 1Meta-analysis: 1Links: 1

Arranging relationship network...

Record Fields

Scalar fields from the final meta_analysis record.

Meta Analysis Id: 548
Evidence Id: 9106
Core Evidence Id: 9106
Source Meta Analysis Id: 527
Herb2 Meta Analysis Id: HBMA000527
Crd Id: CRD42015017418
Title: Leeches (Hirudinea) for osteoarthritis [Cochrane Protocol]
Review Question: To assess the benefits and harms of leeches compared with placebo, no intervention or any other active treatment in people with osteoarthritis.
Study Type Included: Randomised controlled trials (RCTs) and controlled clinical trials. Studies may be single-blind, double-blind, triple-blind or unblinded (i.e. ‘open label’).
Condition Being Studied: The Cochrane Musculoskeletal Group
Participant: Participants will be persons of any age with clinically- or radiologically-confirmed primary osteoarthritis.
Animal
Human Disease Modelled
Intervention: We will consider studies for inclusion where: any leech species is administered to a human host; in any dose (i.e. number of applied leeches, periodicity of exposure); and at any anatomical site.</ul> Leech-derived molecular products are outside the scope of this review, and are not included. Control The control group will receive placebo (i.e. sham leech exposure), no treatment, or any other active intervention.
Comparator Control: The control group will receive placebo (i.e. sham leech exposure), no treatment, or any other active intervention.
Main Outcome: Major outcomes Pain (see Appendix 6 for our proposed hierarchy of data extraction). Function (see Appendix 7 for our proposed hierarchy of data extraction). Radiographic joint structure changes (see Appendix 8 for our proposed hierarchy of data extraction). Change in Quality of Life score. Number of participants experiencing any adverse event. Number of participants experiencing serious adverse events, defined as events resulting in hospitalisation, persistent or significant disability, congenital abnormality or birth defect in offspring, or other life-threatening event or death (European Commission 2010). Dropouts (all-cause study withdrawal, number of participants withdrawing because of adverse effects). If pain or function outcomes are reported at several time points, we will extract the measure at the end of the trial or at a maximum of three months after termination of therapy, whichever came first. Minor outcomes Number of participants experiencing non-serious local adverse events (e.g. pain, itching, infection). Number of participants experiencing non-serious systemic adverse events (e.g. fever, headache, confusion). We will report the above secondary outcomes as additional tables in our review, if appropriate.
Outcome Measure
Additional Outcome: Number of participants experiencing non-serious local adverse events (e.g. pain, itching, infection). Number of participants experiencing non-serious systemic adverse events (e.g. fever, headache, confusion).
Study Method
Keyword: Animals; Leeches; Leeching; Humans; Osteoarthritis
Contact: Ashley M Croft [email protected]
Organisational Affiliation: The Cochrane Collaboration http://www.cochrane.org/
Funding Source: None specified
Other Selection Criteria
Final Publication
Same Topic Review
Published Protocol
Review Type
Language: English
Country: England
Review Stage: Review Ongoing
First Submission Date
Registration Date: 2015-03-09
Anticipated Start Date: 2014-02-15
Anticipated Completion Date: 2016-02-15
Title Cn: 水蛭治疗骨关节炎 [Cochrane方案]
Title En: Leeches (Hirudinea) for osteoarthritis [Cochrane Protocol]
Bilingual Status: complete