Meta AnalysisID 537
桑叶或桑叶提取物对血糖指标的影响：系统评价与Meta分析
CRD42022379199
Bioactive components in mulberry leaves extracts are mainly divided into flavonoids, phenolics, phytosterols, terpenes, γ-aminobutyric acid, alkaloids, and polysaccharides. They play an important role in the treatment of
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Record Fields
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- Meta Analysis Id
- 537
- Evidence Id
- 9095
- Core Evidence Id
- 9095
- Source Meta Analysis Id
- 515
- Herb2 Meta Analysis Id
- HBMA000515
- Crd Id
- CRD42022379199
- Title
- Effect of mulberry leaf or mulberry leaf extracts on glycemic traits: A systematic review and meta-analysis
- Review Question
- Bioactive components in mulberry leaves extracts are mainly divided into flavonoids, phenolics, phytosterols, terpenes, γ-aminobutyric acid, alkaloids, and polysaccharides. They play an important role in the treatment of metabolic diseases including diabetes, dyslipidemia, obesity, atherosclerosis and hypertension. Diabetes mellitus (DM) has become a major global problem with a significant health impact in many countries due to changes in lifestyle and dietary habits. DM is linked to chronic hyperglycemia and abnormal metabolism of carbohydrates, lipids and lipoproteins with an inadequate production of insulin and/or insulin action. A predominant insulin resistance, accompanied by deficient hormone activity, leads to an increase in its secretion. Diabetes control needs essential changes in life-style and behaviors in addition to the process of disease control and management. Nowadays, numerous reporters have found that mulberry leaf extracts (MLE) or mulberry leaf powder (MLP) exhibit significant hypoglycemic effect in high-fat diet, high-fat and high-sugar diet or streptozotocin-induced diabetic animals and cells. Several reviews have previously been published and focused on the active principles in mulberry leaves, and their functional properties. However, there was no meta-analysis on the effect of MLE/MLP on glycemic traits. The aim of the present study was to assess evidence from randomized clinical trials of the effects of MLE/MLP on fasting blood glucose (FBG), glycosylated hemoglobin (HbA1c), and fasting plasma insulin (FPI) in healthy people, diabetics, obese, and other people consuming MLE/MLP compared with the controls.
- Study Type Included
- Study design was RCT, including parallel rows and crossover interventions
- Condition Being Studied
- To study the mechanism of bioactive components from plants on lipid and glucose metabolism based on cell and animal models.
- Participant
- (1) the study design was RCT, including parallel rows and crossover interventions; (2) participants aged between 18 to 75 years old and had unlimited medical conditions, including health, overweight, obesity or diabetes; (3) the intervention duration was not less than 2 weeks; (4) data were presented as means with standard deviations (SD) or standard errors (SE) at baseline or endpoint or both for the outcomes investigated; (5) outcomes included FBG, FPI, and HbA1c;. (6) in studies with ≥ three intervention arms, of which two or three were eligible, only the eligible arms were included.
- Animal
- Human Disease Modelled
- Intervention
- Mulberry leaf-derived products in the form of powders, extracts, tablets, tea, and capsules are now available as functional foods and dietary supplements for controlling blood glucose. The bioactive components in mulberry leaves are mainly divided into flavonoids, phenolics, phytosterols, terpenes, γ-aminobutyric acid, alkaloids, and polysaccharides. 1-DNJ, as a main alkaloid in the mulberry leaves, is an inhibitor of α-glucosidase, which inhibits the elevation of postprandial blood glucose. These active components in mulberry leaves play an important role in the treatment of metabolic diseases including diabetes, dyslipidemia, obesity, atherosclerosis and hypertension. Nowadays, numerous reporters have found that mulberry leaf extracts (MLE) or mulberry leaf powder (MLP) intervention significant suppress the peak glucose level in T2DM patients and non-T2DM patients. The aim of the present study will to assess evidence from randomized clinical trials (RCTs) of the effects of MLE/MLP on fasting blood glucose (FBG), glycosylated hemoglobin (HbA1c), and fasting plasma insulin (FPI) in healthy people, diabetics, obese, and other people consuming MLE/MLP compared with the controls, and to evaluate the medicinal potential of MLE/MLP on the control of glycemic traits.
- Comparator Control
- We expect to find clinical trials examining healthy, prediabetic, diabetic, obese, and other subjects. Thus, the comparators to be included in our study include no treatment and placebo.
- Main Outcome
- The outcomes are primarily fasting blood glucose (FBG), glycosylated hemoglobin (HbA1c), and fasting plasma insulin (FPI) in healthy people, diabetics, obese, and other people consuming MLE/MLP compared with the controls.
- Outcome Measure
- Additional Outcome
- Study Method
- Systematic review
- Keyword
- Alkaloids; Aminobutyrates; Animals; Atherosclerosis; Diabetes Mellitus; Dyslipidemias; Fasting; Flavonoids; Glucose; Glycated Hemoglobin; Habits; Humans; Hyperglycemia; Hypoglycemic Agents; Insulin; Insulin Resistance; Life Style; Lipoproteins; Morus; Obesity; Phytosterols; Polysaccharides; Powders; Randomized Controlled Trials as Topic; Streptozocin; Sugars; Terpenes
- Contact
- Anwei Cheng [email protected]
- Organisational Affiliation
- College of Food Science and Technology, Hunan Agricultural University No. 1 Nongda Road, Changsha, Hunan Province, 410128, China
- Funding Source
- This work was supported by China Agriculture Research System of MOF and MARA, and Science and Technology Innovation Team of Hunan Province.
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2022-11-26
- Registration Date
- 2022-12-07
- Anticipated Start Date
- 2022-10-01
- Anticipated Completion Date
- 2022-12-26
- Title Cn
- 桑叶或桑叶提取物对血糖指标的影响：系统评价与Meta分析
- Title En
- Effect of mulberry leaf or mulberry leaf extracts on glycemic traits: A systematic review and meta-analysis
- Bilingual Status
- complete