Meta AnalysisID 4024
泛素特异性蛋白酶26基因突变与男性不育的相关性：一项Meta分析
CRD42021225251
Whether the mutation in Ubiquitin-specific protease 26 is associtated with male infertility, the currently available results are inconsistent and controversial.The purpose of this investigation is to explore the relation
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 4024
- Evidence Id
- 12582
- Core Evidence Id
- 12582
- Source Meta Analysis Id
- 3982
- Herb2 Meta Analysis Id
- HBMA003982
- Crd Id
- CRD42021225251
- Title
- The association between mutation in Ubiquitin-specific protease 26 and male infertility:a meta-analysis
- Review Question
- Whether the mutation in Ubiquitin-specific protease 26 is associtated with male infertility, the currently available results are inconsistent and controversial.The purpose of this investigation is to explore the relationship between Ubiquitin-specific protease 26 and male infertility.
- Study Type Included
- Case–control studies testing the association of USP26 polymorphisms with male infertility were included.
- Condition Being Studied
- Until now, the group of men whose fertility problems cannot be explained remains large. Genetic factors may explain part of the fertility problems.The ubiquitin-specific protease 26 (USP26) gene is an X-linked gene specifically expressed in testis tissue.This gene is therefore a potential infertility gene.
- Participant
- We aimed to investigate the population classified as azoospermia and oligozoospermia
- Animal
- Human Disease Modelled
- Intervention
- The exposure was the haplotypes of ubiquitin-specific protease 26 in participants
- Comparator Control
- The control was the people proven to be normozoospermia
- Main Outcome
- The incidence rate of infertility in participants and control Measures of effect Odds ratios
- Outcome Measure
- Additional Outcome
- None Measures of effect Odds ratios
- Study Method
- Meta-analysis, Systematic review
- Keyword
- Cysteine Endopeptidases; Humans; Infertility, Male; Male; Mutation; Ubiquitin-Specific Proteases
- Contact
- Qinyu Li [email protected]
- Organisational Affiliation
- Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
- Funding Source
- National Natural Science Foundation of China (Grant Number: 82072838, 81702518) Huazhong University of Science and Technology (Grant Number: 2019kfyXKJC06)
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2020-12-14
- Registration Date
- 2021-01-13
- Anticipated Start Date
- 2020-12-14
- Anticipated Completion Date
- 2021-01-16
- Title Cn
- 泛素特异性蛋白酶26基因突变与男性不育的相关性：一项Meta分析
- Title En
- The association between mutation in Ubiquitin-specific protease 26 and male infertility:a meta-analysis
- Bilingual Status
- complete