Meta AnalysisID 4023

蛋白酶抑制剂及母亲抗逆转录病毒治疗时机对小于胎龄儿风险的影响:一项系统评价与Meta分析

CRD42020218091

What is the risk of giving birth to an SGA infant for women receiving HAART with a PI during pregnancy compared to those receiving HAART without a PI? Is there any difference in the risk of giving birth to an SGA infant

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Record Fields

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Meta Analysis Id
4023
Evidence Id
12581
Core Evidence Id
12581
Source Meta Analysis Id
3981
Herb2 Meta Analysis Id
HBMA003981
Crd Id
CRD42020218091
Title
Protease inhibitors and timing of maternal antiretroviral treatment on the risk of having a small for gestational age infant: a systematic review and meta-analysis
Review Question
What is the risk of giving birth to an SGA infant for women receiving HAART with a PI during pregnancy compared to those receiving HAART without a PI? Is there any difference in the risk of giving birth to an SGA infant when HAART was initiated before conception compared to after conception?
Study Type Included
All studies will be included, except case reports and letters.
Condition Being Studied
HIV
Participant
Women on highly active antiretroviral treatment in pregnancy
Animal
Human Disease Modelled
Intervention
1: Maternal use of HAART that include a protease inhibitor. 2: Maternal use of HAART that is initiated from before pregnancy.
Comparator Control
1: HAART that does not include a protease inhibitor. 2: Maternal use of HAART initiated in pregnancy.
Main Outcome
Small for gestational age (defined as < 10th percentile for their gestational age) Measures of effect Relative risks, odds ratios. Pooled estimate will be adjusted odds ratio.
Outcome Measure
Additional Outcome
Study Method
Epidemiologic, Meta-analysis, Systematic review
Keyword
Anti-Retroviral Agents; Enzyme Therapy; Gestational Age; HIV Infections; Humans; Infant; Infant, Newborn; Infant, Small for Gestational Age; Protease Inhibitors
Contact
Tormod Rebnord [email protected]
Organisational Affiliation
University of Bergen www.uib.no
Funding Source
University of Bergen Grant number(s) <span style=font-size: 14px>State the funder, grant or award number and the date of award</span>
Other Selection Criteria
Final Publication
Same Topic Review
Published Protocol
Review Type
Language
English
Country
Norway
Review Stage
Review Completed not published
First Submission Date
2020-10-29
Registration Date
2020-11-29
Anticipated Start Date
2020-10-30
Anticipated Completion Date
2023-04-01
Title Cn
蛋白酶抑制剂及母亲抗逆转录病毒治疗时机对小于胎龄儿风险的影响:一项系统评价与Meta分析
Title En
Protease inhibitors and timing of maternal antiretroviral treatment on the risk of having a small for gestational age infant: a systematic review and meta-analysis
Bilingual Status
complete