Meta AnalysisID 4011
评估静脉性腿部溃疡渗出液中蛋白酶作为延迟愈合预后因素的作用：系统评价
CRD42014013745
The objective will be to evaluate the prognostic value of protease levels in venous leg ulcer exudate in predicting delayed healing.
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Record Fields
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- Meta Analysis Id
- 4011
- Evidence Id
- 12569
- Core Evidence Id
- 12569
- Source Meta Analysis Id
- 3970
- Herb2 Meta Analysis Id
- HBMA003970
- Crd Id
- CRD42014013745
- Title
- Evaluating the role of proteases in venous leg ulcer exudate as a prognostic factor for delayed healing: a systematic review
- Review Question
- The objective will be to evaluate the prognostic value of protease levels in venous leg ulcer exudate in predicting delayed healing.
- Study Type Included
- Eligible studies will be those of any design (but most likely to be observational) recruiting patients with venous leg ulcers, with protease level as the prognostic factor and healing as the outcome, with some sort of statistical analysis of the relationship between prognostic factor and outcome.
- Condition Being Studied
- Venous leg ulcers are a common and recurring type of chronic wound associated with impaired health-related quality of life and considerable cost to patients and healthcare providers. Despite important developments in treatment strategies over the last 30 years, uncertainty remains in terms of optimal management, particularly in relation to wound assessment and how this might provide prognostic information. Proteases are a group of enzymes that facilitate the breakdown of proteins. They have been found in the exudate of chronic wounds such as venous leg ulcers and it is widely assumed that at higher levels they impair healing, but it is unclear whether this conjecture is supported by research evidence. There is, at present, no published systematic review of the relevant prognostic literature.
- Participant
- Evaluations recruiting participants with venous leg ulcers will be eligible for inclusion. Diagnostic methods vary and we will accept any as described in study reports.
- Animal
- Human Disease Modelled
- Intervention
- The prognostic factor will be protease levels in exudate of venous leg ulcers.
- Comparator Control
- Not applicable for this review.
- Main Outcome
- Wound healing expressed as: time to healing; complete healing; or change in wound size. Measures of effect As reported in the included studies.
- Outcome Measure
- Additional Outcome
- None. Measures of effect Not applicable.
- Study Method
- Keyword
- Exudates and Transudates; Humans; Peptide Hydrolases; Varicose Ulcer;
- Contact
- Dr Susan O'Meara [email protected]
- Organisational Affiliation
- School of Healthcare, University of Leeds http://medhealth.leeds.ac.uk/healthcare
- Funding Source
- School of Healthcare, University of Leeds
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- England
- Review Stage
- Review Discontinued
- First Submission Date
- 2019-07-30
- Registration Date
- 2014-11-07
- Anticipated Start Date
- 2014-12-01
- Anticipated Completion Date
- 2015-11-30
- Title Cn
- 评估静脉性腿部溃疡渗出液中蛋白酶作为延迟愈合预后因素的作用：系统评价
- Title En
- Evaluating the role of proteases in venous leg ulcer exudate as a prognostic factor for delayed healing: a systematic review
- Bilingual Status
- complete