ITCMDBv1
Meta AnalysisID 363

黄芪及其提取物对慢性肾脏病的有效性

CRD42019118652

In the treatment of chronic kidney disease, is the traditional Chinese medicine Huang Qi and its extracts effective?

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Meta Analysis Id
363
Evidence Id
8921
Core Evidence Id
8921
Source Meta Analysis Id
342
Herb2 Meta Analysis Id
HBMA000342
Crd Id
CRD42019118652
Title
The effectiveness of Huang Qi and its extracts on chronic kidney disease
Review Question
In the treatment of chronic kidney disease, is the traditional Chinese medicine Huang Qi and its extracts effective?
Study Type Included
We will include randomised trials to assess the beneficial effects of the treatments, and will supplement these with observational studies (including cohort and case–control studies) for the assessment of harms.
Condition Being Studied
Kidney disease; Hypertensive nephropathy; Diabetic nephropathy; Chronic nephritis; traditional Chinese medicine；Natural plant; plant extract; Combined use of plant extracts and drugs
Participant
Inclusion: Participants included in the study included essential hypertension patients with mild or moderate proteinuria for more than 5 years. There was no obvious clinical manifestation of target organ damage. Exclusion: other serious illnesses or complications; kidney transplant recipients and other types of kidney disease patients.
Animal
Human Disease Modelled
Intervention
In the treatment of chronic kidney disease, there are often serious adverse effects associated with traditional Western medicine treatment. The traditional Chinese medicine compound mixture is gradually recognized by modern medicine, but the research of its active ingredients is still in an immature stage. Related studies have reported basic research on the treatment of diseases with a single Chinese medicine and its extracts. Through preliminary searches, some clinical studies have used Huang Qi and its extracts to treat chronic kidney disease. The purpose of this study was to evaluate the effectiveness of Huang Qi and its extracts in chronic kidney disease.
Comparator Control
Placebo. A group of hypertensive nephropathy patients treated with ARB alone.
Main Outcome
24h urinary protein. Measures of effect Before and after intervention.
Outcome Measure
Additional Outcome
Serum creatinine, urinary creatinine, Urea nitrogen, urine microalbumin, glomerular filtration rate Measures of effect Before and after intervention.
Study Method
Intervention, Meta-analysis, Systematic review
Keyword
Drugs, Chinese Herbal; Huang Qi; Humans; Renal Insufficiency, Chronic
Contact
Yang Xu [email protected]
Organisational Affiliation
Shaanxi University of Chinese Medicine
Funding Source
Studio Construction Project (Shaanzhong Chinese Medicine Letter [2019] No. 82 Studio No.: 2019012) Shaanxi University of Traditional Chinese Medicine First-class Discipline Innovation Team Project (Shaanzhong University Office [2019] No. 2 2019- YL04) Shaanxi Provincial Department of Education Research Program (No. 18 JC009), Shaanxi Provincial Key Research and Development Program (2017SF-305) Chinese Medicine Administration Research and Tendering Theme (JCPT049) 2017 Xianyang Science and Technology Research Project (2016k02- 80)
Other Selection Criteria
Final Publication
Same Topic Review
Published Protocol
Review Type
Language
Chinese-Simplified, English
Country
China
Review Stage
Review Completed not published
First Submission Date
2018-12-05
Registration Date
2019-01-24
Anticipated Start Date
2018-12-05
Anticipated Completion Date
2020-01-07
Title Cn
黄芪及其提取物对慢性肾脏病的有效性
Title En
The effectiveness of Huang Qi and its extracts on chronic kidney disease
Bilingual Status
complete