Meta AnalysisID 173
短链脂肪酸对人类血糖控制的影响：一项系统评价和Meta分析
CRD42021231115
What is the effect of short chain fatty acids (SCFAs) (acetate, propionate and butyrate) on blood glucose and insulin levels in humans?
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 173
- Evidence Id
- 8731
- Core Evidence Id
- 8731
- Source Meta Analysis Id
- 159
- Herb2 Meta Analysis Id
- HBMA000159
- Crd Id
- CRD42021231115
- Title
- The effect of short-chain fatty acids on glycaemic control in humans: a systematic review and meta-analysis
- Review Question
- What is the effect of short chain fatty acids (SCFAs) (acetate, propionate and butyrate) on blood glucose and insulin levels in humans?
- Study Type Included
- Interventional studies preferably randomised clinical trials and in controlled settings if acute.
- Condition Being Studied
- Glycaemic control (glucose and insulin) in humans.
- Participant
- Inclusion: humans (males or females), adults >=18 years old, any gender or ethnicity, and healthy lean, overweight or obese, have metabolic syndrome or type 2 diabetes. Exclusion: children, and having any other disease/syndrome that are not mentioned in the inclusion criteria such as liver disease, type 1 diabetes, etc.
- Animal
- Human Disease Modelled
- Intervention
- Inclusion: Vinegar, Acetate, Propionate and Butyrate administration alone, via routes of administration that include oral, intravenous and gastrointestinal. Administrations both lasting =<24h (acute) and >24h (chronic). Exclusion: SCFA conjugated with other substances that are not salts (i.e. hormones). SCFA combined with another type of fibre.
- Comparator Control
- Inclusion: against placebo Exclusion: When the comparison is done against different health status populations, for example, healthy vs. type 2 diabetic
- Main Outcome
- Quantifiable measures of glycaemic control as main outcomes such as fasting glucose/insulin, postprandial glucose/insulin (i.e. area under the curve), Hb1Ac, insulin sensitivity indexes (i.e. HOMA-IR, clamps). Measures of effect End of intervention values for test and control or change from baseline for test and control (depending on what is available).
- Outcome Measure
- Additional Outcome
- None. Measures of effect Not applicable.
- Study Method
- Intervention, Meta-analysis, Narrative synthesis, Systematic review
- Keyword
- Blood Glucose; Fatty Acids; Fatty Acids, Volatile; Glycemic Control; Humans
- Contact
- Anna Cherta-Murillo [email protected]
- Organisational Affiliation
- Imperial College London https://www.imperial.ac.uk/nutrition-and-food-centre
- Funding Source
- Quorn Foods Ltd. Imperial College London. Ministry of Higher Education, United Arab Emirates. The Section for Nutrition Research, Department of Metabolism, Digestion and Reproduction is funded by grants from the MRC, BBSRC, NIHR, an Integrative Mammalian Biology (IMB) Capacity Building Award, an FP7- HEALTH- 2009- 241592 EuroCHIP grant and is supported by the NIHR Biomedical Research Centre Funding Scheme.
- Other Selection Criteria
- Final Publication
- Not yet
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- England
- Review Stage
- Review Completed not published
- First Submission Date
- 2021-01-14
- Registration Date
- 2021-01-25
- Anticipated Start Date
- 2020-11-15
- Anticipated Completion Date
- 2021-03-31
- Title Cn
- 短链脂肪酸对人类血糖控制的影响：一项系统评价和Meta分析
- Title En
- The effect of short-chain fatty acids on glycaemic control in humans: a systematic review and meta-analysis
- Bilingual Status
- complete