Meta AnalysisID 13
艾灸对下腰痛患者炎性细胞因子的影响：系统评价、Meta分析与Meta回归
CRD42022357108
Is moxibustion effective on the regulation of inflammatory cytokines for patients with low back pain? It is a systematic review and meta-analysis of randomized controlled trials.
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 13
- Evidence Id
- 8571
- Core Evidence Id
- 8571
- Source Meta Analysis Id
- 13
- Herb2 Meta Analysis Id
- HBMA000013
- Crd Id
- CRD42022357108
- Title
- Effect of moxibustion on inflammatory cytokines in patients with low back pain: a systematic review, meta-analysis, and meta-regression
- Review Question
- Is moxibustion effective on the regulation of inflammatory cytokines for patients with low back pain? It is a systematic review and meta-analysis of randomized controlled trials.
- Study Type Included
- Randomized controlled trials (RCTs) focused on human trials will be included.
- Condition Being Studied
- Low back pain (LBP) is a common problem worldwide. The pathological features of LBP involve many links, which include the production of pro-inflammatory mediators. Recent evidence supports that pro-inflammatory cytokines as well as anti-inflammatory cytokines play an important part in LBP. To date, many pharmacological therapies have been widely used to treat LBP by regulating inflammatory cytokines, but the side effects of Western medicine are common in clinic. Therefore, alternative therapy without side effect is gradually becoming a trend to treat LBP. Moxibustion therapy is a branch of traditional Chinese medicine. In China and Japan, it has been widely used to treat LBP. However, the mechanism of moxibustion to treat LBP remains unclear. Inflammatory response is important in the progression and prognosis of LBP. Therefore, it deserves our exploration to analyze whether moxibustion can treat LBP by regulating inflammatory response. Inflammatory responses are induced by inflammatory cytokine overexpression. Several studies showed that patients treated with moxibustion had lower levels of proinflammatory cytokines than those in the control group. But there is a lack of systematic review to summarize the evidence of moxibustion on inflammatory cytokines in patients with LBP.
- Participant
- This systematic review focus on patients with LBP. Disorders that lead to LBP, such as lumbar disc herniation (LDH), intervertebral disc degeneration (IDD), spinal stenosis, sciatica, ankylosing spondylitis, failed back surgery syndrome, will also be included.
- Animal
- Human Disease Modelled
- Intervention
- This systematic review focus on moxibustion therapy. As a complementary medicine, moxibustion is a technique that involves the burning of mugwort (moxa, Artemisia argyi) to facilitate healing over specific acupuncture points.
- Comparator Control
- There is no restriction on interventions in the control group.
- Main Outcome
- The primary outcomes considered are inflammatory cytokines, including TNF-α, interferon (IFN-) α, IFN-γ, IL-1β, IL-2, IL-4, IL-6, IL-10, IL-17.
- Outcome Measure
- Additional Outcome
- The secondary outcome is incidence rate of adverse events related to moxibustion intervention.
- Study Method
- Meta-analysis, Systematic review
- Keyword
- Cytokines; Humans; Low Back Pain; Moxibustion
- Contact
- Zhenni Zhao [email protected]
- Organisational Affiliation
- Nanjing University of Chinese Medicine
- Funding Source
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2022-08-31
- Registration Date
- 2022-09-11
- Anticipated Start Date
- 2022-03-01
- Anticipated Completion Date
- 2022-09-30
- Title Cn
- 艾灸对下腰痛患者炎性细胞因子的影响：系统评价、Meta分析与Meta回归
- Title En
- Effect of moxibustion on inflammatory cytokines in patients with low back pain: a systematic review, meta-analysis, and meta-regression
- Bilingual Status
- complete