Meta AnalysisID 116
薄荷对恶心呕吐的疗效：随机对照试验的系统评价和Meta分析
CRD42022379103
Is peppermint effective in the treatment of nausea and vomiting symptoms in adults compared to placebo, standard treatment or no treatment?
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 116
- Evidence Id
- 8674
- Core Evidence Id
- 8674
- Source Meta Analysis Id
- 104
- Herb2 Meta Analysis Id
- HBMA000104
- Crd Id
- CRD42022379103
- Title
- Efficacy of peppermint on nausea and vomiting: a systematic review and meta-analysis of randomized controlled trials
- Review Question
- Is peppermint effective in the treatment of nausea and vomiting symptoms in adults compared to placebo, standard treatment or no treatment?
- Study Type Included
- Randomized controlled and controlled clinical trials will be included.
- Condition Being Studied
- Investigating the efficacy of peppermint on the severity of postoperative nausea and vomiting (PONV), chemotherapy-induced nausea and vomiting (CINV), or nausea and vomiting during pregnancy. PONV is a common side effect following surgery, and CINV is a common adverse effect among cancer patients. Nausea and vomiting not only impact the quality of life but also the treatment outcomes. Nausea and vomiting during pregnancy involve increased health risks for the pregnant women and the fetus. Current pharmaceutical treatments for nausea and vomiting are not always effective or have unpleasant adverse effects. Also, during pregnancy, the possible treatment options are limited. Medicinal herbs could be alternative options for treating the symptoms as they are inexpensive, non‐invasive, and have low levels of adverse effects compared to standard pharmacological treatments. One alternative option could be peppermint oil as it could lower the symptoms of nausea and vomiting by acting on the 5-HT(3) (5-hydroxytryptamine-3) receptor. Although peppermint is a well-known medicinal herb, its clinical effectiveness is not known for the treatment of nausea and vomiting symptoms.
- Participant
- P1: Adult patients (over 18 years) experiencing nausea and vomiting postoperatively P2: Adult patients (over 18 years) experiencing nausea and vomiting due to chemotherapy P3: Adult patients (over 18 years) experiencing nausea and vomiting during pregnancy
- Animal
- Human Disease Modelled
- Intervention
- Peppermint as a standalone or an add-on treatment
- Comparator Control
- Placebo, standard treatment or no treatment
- Main Outcome
- Changes in severity of nausea measured by the Visual analogue scale Rhodes Index for the severity of nausea and vomiting Measures of effect standardized mean difference with a 95% confidence interval, mean (MD) difference with a 95% confidence interval (CI)
- Outcome Measure
- Additional Outcome
- Overall satisfaction Frequency of nausea and vomiting Duration of nausea Requested rescue antiemetics Intravenous antiemetics at any time Measures of effect standardized mean difference with a 95% confidence interval, mean (MD) difference with a 95% confidence interval (CI)
- Study Method
- Meta-analysis, Systematic review
- Keyword
- Adult; Humans; Mentha piperita; Nausea; Randomized Controlled Trials as Topic; Vomiting
- Contact
- Dorottya Gergő [email protected]
- Organisational Affiliation
- Centre for Translational Medicine, Semmelweis University, Budapest, Hungary Faculty of Pharmacy, Department of Pharmacognosy, Semmelweis University, Budapest, Hungary https://tm-centre.org/
- Funding Source
- Centre for Translational Medicine, Semmelweis University
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Peppermint; Nausea; Vomiting; Postoperative; Chemotherapy; Pregnancy
- Published Protocol
- Review Type
- Language
- English
- Country
- Hungary
- Review Stage
- Review Ongoing
- First Submission Date
- 2022-11-25
- Registration Date
- 2022-12-07
- Anticipated Start Date
- 2022-11-25
- Anticipated Completion Date
- 2023-05-31
- Title Cn
- 薄荷对恶心呕吐的疗效：随机对照试验的系统评价和Meta分析
- Title En
- Efficacy of peppermint on nausea and vomiting: a systematic review and meta-analysis of randomized controlled trials
- Bilingual Status
- complete