Meta AnalysisID 11
麦粒灸治疗偏瘫的疗效与安全性：系统评价与Meta分析方案
CRD42018117765
To determine the efficacy and safety of grain-moxibustion in hemiplegia. PICOS: P (Population): patients with hemiplegia; I (Intervention): grain-moxibustion; C (Comparison): conventional medicine therapy; O (Outcome): t
Relationship Network
Interactive first-hop connections across herbs, ingredients, formulas, targets, diseases, symptoms, syndromes, evidence, and monographs.
Click a node to open it in a new tab
Herb: 1Meta-analysis: 1Links: 1
Arranging relationship network...
Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 11
- Evidence Id
- 8569
- Core Evidence Id
- 8569
- Source Meta Analysis Id
- 11
- Herb2 Meta Analysis Id
- HBMA000011
- Crd Id
- CRD42018117765
- Title
- Efficacy and safety of grain-moxibustion in hemiplegia: a systematic review and meta‑analysis protocol
- Review Question
- To determine the efficacy and safety of grain-moxibustion in hemiplegia. PICOS: P (Population): patients with hemiplegia; I (Intervention): grain-moxibustion; C (Comparison): conventional medicine therapy; O (Outcome): total effective rate, etc; S (Study design): RCTs.
- Study Type Included
- Except for those references with incomplete or wrong data, all randomized controlled trial will be included, irrespective of language and publication status.
- Condition Being Studied
- Stroke is an acute cerebrovascular event caused by brain ischemia, which has become the second leading cause of death. Affecting greatly the ability of patients to take care of themselves, so that stroke has caused great economic burden to the society. There are 10.3 million new strokes and 113 million disability-adjusted life years per year. Economic development is closely related to morbidity, and it was reported that stroke incidence in high-income countries decreased by 42% while incidence showed 100% increase in low-income and middle-income countries in the past four decades. Spasticity, a common nerve injury symptoms in stroke, which is characterized as passive elongation of the involved muscle. At present, botulinum neurotoxin injection therapy combined with rehabilitation has been applied for stroke patients to reduce the spasticity of limbs with a positive effect on nerve recovery. However, as a bacterial endotoxin, botulinum toxin can cause allergic reactions, such as dizziness, tachycardia, redness, swelling, etc. Therefore, it is necessary to find other effective alternative therapies to minimize the devastating effects of stroke.
- Participant
- Patients involved suffered from hemiplegia (and meeting at least one of the current or past definitions of hemiplegia). No age, sex or race limit.
- Animal
- Human Disease Modelled
- Intervention
- In Asia, acupuncture and moxibustion are widely used in the rehabilitation of stroke patients with spastic hemiplegia as the comprehensive therapy. As a percutaneous therapy, moxibustion can permeate the volatile components and heat into acupoints through burned mugwort (Artemisia vulgaris) floss according to the theory of TCM, spastic hemiplegia in stroke is mainly related to the imbalance of Yin and Yang. Phlegh-damp, weakness, pathogenic wind and blood stasis are the main pathological factors. Moxibustion can warm up cold phlegm and dispel wind by its drug action and warm effect, and further induce flow of blood and qi to facilitate recovery from cerebral ischemic. Grain-moxibustion, different from indirect moxibustion, has the advantages of large amount of stimulation, concentrated position and strong permeability through direct acting on acupoints. It can stimulate human immune function instantaneously to promote qi and activating blood, finally restore balance of limb function. Avoiding the pain of acupuncture and overdose inhalation of mugwort smoke, it not only improves the peripheral circulation, but also affects the central cerebral cortex reflectively.
- Comparator Control
- RCTs comparing grain-moxibustion used alone versus drugs will be included. If, however, trials have assessed the combined effect of grain-moxibustion with other interventions, such as another herbal formula, qigong, tai chi, acupuncture, yoga or massage, they will be excluded, as the therapeutic effect of the grain-moxibustion may not be distinguishable from the effect of the additional therapy. In addition, studies using non-conventional medicine in their control groups will also be excluded.
- Main Outcome
- Total effective rate. Measures of effect To be calculated at the end of the test.
- Outcome Measure
- Additional Outcome
- Quality of life index (QLI) Measures of effect To be calculated at the end of the test.
- Study Method
- Systematic review
- Keyword
- Acupuncture Therapy; Hemiplegia; Humans; Moxibustion
- Contact
- Guoming Chen [email protected]
- Organisational Affiliation
- Guangzhou University of Chinese Medicine http://www.gzucm.edu.cn/
- Funding Source
- No funding
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2018-11-26
- Registration Date
- 2018-12-13
- Anticipated Start Date
- 2018-12-18
- Anticipated Completion Date
- 2020-12-18
- Title Cn
- 麦粒灸治疗偏瘫的疗效与安全性：系统评价与Meta分析方案
- Title En
- Efficacy and safety of grain-moxibustion in hemiplegia: a systematic review and meta‑analysis protocol
- Bilingual Status
- complete