DiseaseID 3245
Conn综合征
disease
Cushing disease (CD) is the most common cause of endogenous Cushing syndrome (CS; see this term) and is due to pituitary chronic over-secretion of ACTH by a pituitary corticotroph adenoma.
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Disease: 1Herb: 4Symptom: 12Target: 24Links: 40
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Record Fields
Scalar fields from the final disease record.
- Disease Id
- 3245
- Core Entity Id
- 59427
- Source Entity Count
- 1
- Preferred Name
- Conn Syndrome
- Name Cn
- Conn综合征
- Name Pinyin
- Conn Zong He Zheng
- Name En
- Conn Syndrome
- Name Latin
- Bilingual Status
- complete
- Disease Type
- disease
- Umls Disease Type
- Disease or Syndrome
- Disgenet Type
- disease
- Mesh Class
- Endocrine System DiseasesNervous System Diseases; Endocrine System DiseasesNervous System Diseases; Neoplasms; Endocrine System DiseasesSkin and Connective Tissue Diseases; Female Urogenital Diseases and Pregnancy Complications
- Do Class
- disease of anatomical entitydisease of anatomical entity; disease of cellular proliferationdisease of metabolism
- Hpo Class
- Abnormality of the endocrine systemAbnormality of the nervous system; Abnormality of the endocrine system
- Mesh Class Name
- Endocrine System DiseasesFemale Urogenital Diseases and Pregnancy Complications; Skin and Connective Tissue DiseasesNeoplasms; Nervous System Diseases; Endocrine System DiseasesNervous System Diseases; Endocrine System Diseases
- Hpo Class Name
- Abnormality of the endocrine systemAbnormality of the endocrine system; Abnormality of the nervous system
- Do Class Name
- disease of anatomical entitydisease of anatomical entity; disease of cellular proliferationdisease of metabolism
- Disease Definition
- Cushing disease (CD) is the most common cause of endogenous Cushing syndrome (CS; see this term) and is due to pituitary chronic over-secretion of ACTH by a pituitary corticotroph adenoma.
- Version
- v1
- Suppressed
- No
Names
Preferred names, aliases, and source labels retained in the final schema.
Name
Conn Syndrome
Role
preferred
Name
Adrenal Gland Hyperfunction
Role
preferred
Name
Chiari-Frommel Syndrome
Role
preferred
Name
Familial Hyperaldosteronism Type Iii
Role
preferred
Name
Hyperaldosteronism
Role
preferred
Name
Hyperaldosteronism, Familial, Type Ii
Role
preferred
Name
Hyperaldosteronism, Familial, Type Iii
Role
preferred
Name
Aldosterone-Producing Adenoma With Seizures And Neurological Abnormalities
Role
preferred
Name
Benign Neoplasm of Pituitary Gland
Role
preferred
Name
Cushing Disease
Role
preferred
Name
Cushing Syndrome
Role
preferred
Name
Familial Hyperaldosteronism
Role
preferred
Name
Hyperaldosteronism, Familial, Type I
Role
preferred
Name
Hyperprolactinemia
Role
preferred
Name
Idiopathic Hyperprolactinemia
Role
preferred
Name
Increased Circulating Cortisol Level
Role
preferred
Name
Pituitary Adenoma, Prolactin-Secreting
Role
preferred
Name
Adrenocortical Hyperfunction
Role
alias
Name
Conn'S Syndrome
Role
alias
Name
Cushing'S Syndrome
Role
alias
Name
Cushing'S Syndrome, Unspecified
Role
alias
Name
Elevated Plasma Aldosterone
Role
alias
Name
FH III
Role
alias
Name
FH3
Role
alias
Name
Familial Hyperaldosteronism Type 3
Role
alias
Name
HALD3
Role
alias
Name
Hyperaldosteronism, Unspecified
Role
alias
Name
Hypercortisolism
Role
alias
Name
Hyperprolactinaemia
Role
alias
Name
Increased Aldosterone
Role
alias
Name
Increased Aldosterone Production
Role
alias
Name
Increased Cortisol Production
Role
alias
Name
Mineralocorticoid Excess
Role
alias
Name
Pituitary Gland
Role
alias
Name
Primary Hyperaldosteronism
Role
alias
Name
Prolactin Excess
Role
alias
Cross References
Trusted external identifiers retained for this final record.
Hpo
HP:0000859HP:0000870HP:0003118HP:0011736
Herb
HBDIS000070HBDIS000532HBDIS000695HBDIS001417HBDIS001455HBDIS006613HBDIS009760HBDIS014087HBDIS017010HBDIS020718HBDIS022082HBDIS025088
Me Sh
D000308D002640D003480D006929D006966
Omim
613677615555
Umls
C0001622C0008043C0010481C0020428C0020514C0033375C1260386C1384514C1854107C3150933
Icd10
D35.2E22.1E24E24.9E26E26.0E26.01E26.9
Med Dra
1003510910036832
Sym Map
SMDE00186SMDE00842SMDE01698SMDE02226SMDE03066SMDE03122SMDE05162SMDE05555SMDE06960SMDE07517SMDE07667SMDE09585SMDE09586
Do Class
DOID:0014667DOID:14566DOID:7
Dis Ge Net
C0001622C0008043C0010481C0020428C0020514C0271552C0496901C1384514C1854107C3150933C3713420C4025651
Orphanet
251274296536992940396253
Umls Sty
T033T047T191
Hpo Class
HP:0000707HP:0000818
Me Sh Class
C04C10C13C17C19
Etcm Disease
Hyperaldosteronism, Familial, Type IHyperaldosteronism, Familial, Type IiHyperaldosteronism, Familial, Type IiiHyperprolactinemia
Tcmbank Disease
1001715031712317267196622015424575247672542275929594307363110142665259
Itcmdb Generated
ITX-DISEASE-0D3778B7B7F6ITX-DISEASE-47B377B8E102ITX-DISEASE-633475C15DF3ITX-DISEASE-77E7F266CA69ITX-DISEASE-C8313647B080ITX-DISEASE-F04A58912D91ITX-DISEASE-F4692E3CB387ITX-DISEASE-F48AAAFDD104
Attributes
Merged source attributes and domain-specific metadata.
Version
v1v1,v2v2
Suppress
0
Page Title
Disease Hyperaldosteronism, Familial, Type I Details pageDisease Hyperaldosteronism, Familial, Type Ii Details pageDisease Hyperaldosteronism, Familial, Type Iii Details pageDisease Hyperprolactinemia Details page
Do Class Name
disease of anatomical entitydisease of anatomical entity; disease of cellular proliferationdisease of metabolism
Disease Type
diseasephenotype
Hpo Class Name
Abnormality of the endocrine systemAbnormality of the endocrine system; Abnormality of the nervous system
Do Disease Class
disease of anatomical entitydisease of anatomical entity; disease of cellular proliferationdisease of metabolism
Hpo Disease Class
Abnormality of the endocrine systemAbnormality of the nervous system; Abnormality of the endocrine system
Umls Disease Type
Disease or SyndromeFindingNeoplastic Process
Basic Information
Disease Name
Hyperaldosteronism, Familial, Type I
Global Category
Genetic diseases;Rare diseases
Anatomical Category
Blood diseases;Cardiovascular diseases;Endocrine diseases;Nephrological diseases
Disease Name
Hyperaldosteronism, Familial, Type Ii
Global Category
Genetic diseases;Rare diseases
Anatomical Category
Blood diseases;Cardiovascular diseases;Endocrine diseases;Nephrological diseases
Disease Name
Hyperaldosteronism, Familial, Type Iii
Global Category
Genetic diseases;Rare diseases
Anatomical Category
Blood diseases;Cardiovascular diseases;Endocrine diseases;Nephrological diseases
Disease Name
Hyperprolactinemia
Global Category
Genetic diseases;Metabolic diseases;Rare diseases
Anatomical Category
Blood diseases;Endocrine diseases;Reproductive diseases
Disease Definition
Cushing disease (CD) is the most common cause of endogenous Cushing syndrome (CS; see this term) and is due to pituitary chronic over-secretion of ACTH by a pituitary corticotroph adenoma.Familial hyperaldosteronism type III (FH-III) is a rare heritable form of primary aldosteronism (PA) that is characterized by early-onset severe hypertension, non glucocorticoid-remediable hyperaldostMSH2017_2016_08_12:A POSTPARTUM condition consists of persistent lactation (GALACTORRHEA) and AMENORRHEA in patients not BREAST FEEDING.NCI2016_02D:An adenoma of the anterior lobe of the pituitary gland that produces prolactin. It is the most common type of pituitary gland adenomas and it is associated with hyperprolactinemia. Clinical manifestations include amenorrhea, galactorrhea, impotence, headache, and visual disturbances.|MSH2017_2016_08_12:A pituitary adenoma which secretes PROLACTIN, leading to HYPERPROLACTINEMIA. Clinical manifestations include AMENORRHEA; GALACTORRHEA; IMPOTENCE; HEADACHE; visual disturbances; and CEREBROSPINAL FLUID RHINORRHEA.|HPO2016_07_04:A type of pituitary adenoma originating in prolactin secreting cells. This kind of adenoma is characterized by overproduction of prolactin, and may cause loss of menstrual periods and breast milk production in women. [DDD:spark]NCI2016_02D:An endocrine disorder characterized by excessive production of aldosterone by the adrenal glands. Causes include adrenal gland adenoma and adrenal gland hyperplasia. The overproduction of aldosterone results in sodium and water retention and hypokalemia. Patients present with high blood pressure, muscle weakness, and headache.|MSH2017_2016_08_12:Primary hyperaldosteronism caused by the excess production of ALDOSTERONE by an ADENOMA of the ZONA GLOMERULOSA or CONN ADENOMA.|HPO2016_07_04:A form of hyperaldosteronism caused by a defect within the adrenal gland. [DDD:spark]|CSP2006:overproduction of aldosterone by an adrenal cortical adenoma, characterized typically by low potassium levels, underacidity of the body, muscular weakness, excess urination, excess thirst, and high blood pressure.NCI2016_NICHD_1602D:A constellation of signs and symptoms associated with abnormally high levels of cortisol in the body. It may be characterized by central obesity, hypertension, abnormal glucose tolerance, and other physical findings.|NCI2016_NCI-GLOSS_1602D:A condition in which there is too much cortisol (a hormone made by the outer layer of the adrenal gland) in the body. Cushing syndrome may be caused by taking too many steroid drugs or by certain types of tumors. Tumors that make adrenocorticotropic hormone (ACTH) cause the adrenal gland to make too much cortisol. Symptoms of Cushing syndrome include a round face, thin arms and legs, severe fatigue and muscle weakness, high blood pressure, high blood sugar, purple or pink stretch marks on the skin, and weight gain, especially in the abdomen.|NCI2016_02D:A syndrome caused by high levels of cortisol in the blood either due to excessive production and secretion of corticosteroids secondary to pituitary or adrenocortical neoplasms, or intake of glucocorticoid drugs. Signs and symptoms include a round face, upper body obesity, fragile and thin skin, purple stretch marks in the skin, fatigue, muscle weakness, hypertension, diabetes mellitus, hypertrichosis and amenorrhea in women, impotence in men, and osteoporosis.|MSH2017_2016_08_12:A condition caused by prolonged exposure to excess levels of cortisol (HYDROCORTISONE) or other GLUCOCORTICOIDS from endogenous or exogenous sources. It is characterized by upper body OBESITY; OSTEOPOROSIS; HYPERTENSION; DIABETES MELLITUS; HIRSUTISM; AMENORRHEA; and excess body fluid. Endogenous Cushing syndrome or spontaneous hypercortisolism is divided into two groups, those due to an excess of ADRENOCORTICOTROPIN and those that are ACTH-independent.|MEDLINEPLUS_20151021:<p>Cushing's syndrome is a hormonal disorder. The cause is long-term exposure to too much cortisol, a hormone that your adrenal gland makes. Sometimes, taking synthetic hormone medicine to treat an inflammatory disease leads to Cushing's. Some kinds of tumors produce a hormone that can cause your body to make too much cortisol.</p> <p>Cushing's syndrome is rare. Some symptoms are</p> <ul> <li>Upper body obesity </li> <li>Thin arms and legs</li> <li>Severe fatigue and muscle weakness</li> <li>High blood pressure</li> <li>High blood sugar</li> <li>Easy bruising</li> </ul> <p>Lab tests can show if you have it and find the cause. Your treatment will depend on why you have too much cortisol. If it is because you have been taking synthetic hormones, a lower dose may control your symptoms. If the cause is a tumor, surgery and other therapies may be needed.</p> <p >NIH: National Institute of Diabetes and Digestive and Kidney Diseases</p>|CSP2006:condition, more commonly seen in females, due to hyperadrenocorticism resulting from neoplasms of the adrenal cortex or the anterior lobe of the pituitary, or to prolonged excessive intake of glucocorticoids for therapeutic purposes; symptoms and signs may include rapidly developing adiposity of the face, neck, and trunk, kyphosis caused by osteoporosis of the spine, hypertension, diabetes mellitus, amenorrhea, hypertrichosis in females, impotence in males, dusky complexion with purple markings, polycythemia, pain in the abdomen and back, and muscular wasting and weakness.|CHV2011_02:a rare hormonal disease that occurs when the body produces too much of the hormone cortisol|CHV2011_02:a rare hormonal disease that occurs when the body produces too much of the hormone cortisolNCI2016_NICHD_1602D:Abnormally high level of prolactin in the blood.|NCI2016_02D:Abnormally high level of prolactin in the blood.|MSH2017_2016_08_12:Increased levels of PROLACTIN in the BLOOD, which may be associated with AMENORRHEA and GALACTORRHEA. Relatively common etiologies include PROLACTINOMA, medication effect, KIDNEY FAILURE, granulomatous diseases of the PITUITARY GLAND, and disorders which interfere with the hypothalamic inhibition of prolactin release. Ectopic (non-pituitary) production of prolactin may also occur. (From Joynt, Clinical Neurology, 1992, Ch36, pp77-8)|HPO2016_07_04:The presence of abnormally increased levels of prolactin in the blood. Prolactin is a peptide hormone produced by the anterior pituitary gland that plays a role in breast development and lactation during pregnancy. [DDD:spark, HPO:probinson]|CSP2006:increased levels of prolactin in the blood, which may be associated with amenorrhea and galactorrhea; relatively common etiologies include prolactinoma, medication effect, kidney failure, granulomatous diseases of the pituitary gland, and disorders which interfere with the hypothalamic inhibition of prolactin release; ectopic (non-pituitary) production of prolactin may also occur.NCI2016_NICHD_1602D:Abnormally high levels of cortisol in the blood.|NCI2016_02D:Abnormally high level of cortisol in the blood.(NICHD)|MSH2017_2016_08_12:Excess production of ADRENAL CORTEX HORMONES such as ALDOSTERONE; HYDROCORTISONE; DEHYDROEPIANDROSTERONE; and/or ANDROSTENEDIONE. Hyperadrenal syndromes include CUSHING SYNDROME; HYPERALDOSTERONISM; and VIRILISM.|HPO2016_07_04:Overproduction of the hormone of cortisol by the adrenal cortex, resulting in a characteristic combination of clinical symptoms termed Cushing syndrome, with truncal obesity, a round, full face, striae atrophicae and acne, muscle weakness, and other features. [DDD:spark, HPO:probinson]|CSP2006:complex of symptoms and signs due to excessive production or administration of hydrocortisone or its semi-synthetic analogs.|CSP2006:abnormally increased secretion of adrenal hormones.NCI2016_NICHD_1602D:Excessive production of aldosterone and elevation of blood pressure by the adrenal gland, which is regulated by corticotropin.|NCI2016_02D:Excessive production of aldosterone and elevation of blood pressure by the adrenal gland, which is regulated by corticotropin.(NICHD)NCI2016_NICHD_1602D:Overproduction of aldosterone by the adrenal glands, which may lead to hypokalemia and/or hypernatremia.|NCI2016_02D:Overproduction of aldosterone by the adrenal glands, which may lead to hypokalemia and/or hypernatremia.(NICHD)|MSH2017_2016_08_12:A condition caused by the overproduction of ALDOSTERONE. It is characterized by sodium retention and potassium excretion with resultant HYPERTENSION and HYPOKALEMIA.|HPO2016_07_04:Overproduction of the mineralocorticoid aldosterone by the adrenal cortex. [DDD:spark, HPO:probinson]|CSP2006:abnormality of electrolyte function caused by excessive secretion of aldosterone by the adrenal cortex.
Me Sh Disease Class
Endocrine System DiseasesNervous System Diseases; Endocrine System DiseasesNervous System Diseases; Neoplasms; Endocrine System DiseasesSkin and Connective Tissue Diseases; Female Urogenital Diseases and Pregnancy Complications
Dis Ge Net Disease Type
diseasephenotype
Disease Class Name Me Sh
Endocrine System DiseasesFemale Urogenital Diseases and Pregnancy Complications; Skin and Connective Tissue DiseasesNeoplasms; Nervous System Diseases; Endocrine System DiseasesNervous System Diseases; Endocrine System Diseases
Umls Semantic Type Name
Disease or SyndromeFindingNeoplastic Process