DiseaseID 11080

硬斑病

disease

HPO2016_07_04:Isolated patches of hardened skin (scleroderma). [HPO:probinson]

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Disease: 1Experiment: 2Formula: 17Herb: 12Symptom: 12Target: 24Links: 67

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Record Fields

Scalar fields from the final disease record.

Disease Id: 11080
Core Entity Id: 68373
Source Entity Count: 1
Preferred Name: Morphea
Name Cn: 硬斑病
Name Pinyin: Ying Ban Bing
Name En: Morphea
Name Latin
Bilingual Status: complete
Disease Type: disease
Umls Disease Type: Disease or Syndrome
Disgenet Type: disease
Mesh Class: Cardiovascular Diseases; Digestive System Diseases; Skin and Connective Tissue Diseases; Nutritional and Metabolic DiseasesDigestive System Diseases; Pathological Conditions, Signs and SymptomsDigestive System Diseases; Skin and Connective Tissue Diseases; Pathological Conditions, Signs and SymptomsSkin and Connective Tissue Diseases
Do Class: disease of anatomical entitydisease of anatomical entity; syndrome
Hpo Class: Abnormality of the digestive systemAbnormality of the integument
Mesh Class Name: Digestive System Diseases; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases; Cardiovascular DiseasesPathological Conditions, Signs and Symptoms; Digestive System DiseasesPathological Conditions, Signs and Symptoms; Digestive System Diseases; Skin and Connective Tissue DiseasesSkin and Connective Tissue Diseases
Hpo Class Name: Abnormality of the digestive systemAbnormality of the integument
Do Class Name: disease of anatomical entitydisease of anatomical entity; syndrome
Disease Definition: HPO2016_07_04:Isolated patches of hardened skin (scleroderma). [HPO:probinson]
Version: v1,v2
Suppressed: No

Names

Preferred names, aliases, and source labels retained in the final schema.

Name

Morphea

Role

preferred

Name

Biliary Cirrhosis

Role

preferred

Name

Localized Scleroderma

Role

preferred

Name

Reynolds Syndrome

Role

preferred

Name

Scleroderma

Role

preferred

Name

Biliary Cirrhosis, Primary, 1

Role

preferred

Name

CREST Syndrome

Role

preferred

Name

Linear Scleroderma

Role

preferred

Name

Primary Biliary Cirrhosis

Role

preferred

Name

Scleroderma-Like Secondary Cutaneous Sclerosis

Role

preferred

Name

Secondary Biliary Cholangitis

Role

preferred

Name

Systemic Scleroderma

Role

preferred

Name

Biliary Cirrhosis, Primary

Role

alias

Name

Biliary Cirrhosis, Unspecified

Role

alias

Name

Cirrhosis, Biliary

Role

alias

Name

Cr(E)St Syndrome

Role

alias

Name

Dermatosclerosis

Role

alias

Name

Liver Cirrhosis, Biliary

Role

alias

Name

Localized Scleroderma [Morphea]

Role

alias

Name

PRIMARY BILIARY CIRRHOSIS, SCLERODERMA, RAYNAUD DISEASE, AND TELANGIECTASIA

Role

alias

Name

Pbc

Role

alias

Name

Primary Biliary Cirrhosis And Systemic Scleroderma

Role

alias

Name

Progressive Systemic Scleroderma

Role

alias

Name

Progressive Systemic Sclerosis

Role

alias

Name

Pseudoscleroderma

Role

alias

Name

Scleroderma, Localized

Role

alias

Name

Scleroderma, Systemic

Role

alias

Name

Secondary Biliary Cirrhosis

Role

alias

Name

Systemic Sclerosis

Role

alias

Name

Systemic Sclerosis, Unspecified

Role

alias

Cross References

Trusted external identifiers retained for this final record.

Hpo

HP:0002613HP:0012344HP:0100324

Herb

HBDIS000546HBDIS000767HBDIS001767HBDIS002699HBDIS002700HBDIS004336HBDIS005109HBDIS005570HBDIS011024HBDIS014462HBDIS027257HBDIS028653

Me Sh

D008105D012594D012595D017675

Omim

109720181750613471

Umls

C0011644C0023892C0036420C0036421C0206138C0748397C1527383

Icd10

K74.3K74.4K74.5L94.0L94.1M34M34.0M34.1M34.9

Sym Map

SMDE02577SMDE06428SMDE07626SMDE10504SMDE11084SMDE12433SMDE12995SMDE13781

Do Class

DOID:225DOID:7

Dis Ge Net

C0008312C0011644C0023892C0036420C0036421C0206138C0238065C0263409C0748397C1274865C1527383C4551595

Orphanet

779

Umls Sty

T047

Hpo Class

HP:0001574HP:0025031

Me Sh Class

C06C14C17C18C23

Etcm Disease

Biliary Cirrhosis, Primary, 1Localized Scleroderma

Tcmbank Disease

10734187222016120482174023149243782682430162304023838502562577719

Itcmdb Generated

ITX-DISEASE-19022A85B420ITX-DISEASE-1B687DA9F8A8ITX-DISEASE-728800A15A01ITX-DISEASE-AC1FBE7B515DITX-DISEASE-B9749A353B84ITX-DISEASE-D1CF01A5F4ECITX-DISEASE-D25436CAE372ITX-DISEASE-FD47C8D9BC60

Attributes

Merged source attributes and domain-specific metadata.

Version

v1,v2v2

Suppress

Page Title

Disease Biliary Cirrhosis, Primary, 1 Details pageDisease Localized Scleroderma Details page

Do Class Name

disease of anatomical entitydisease of anatomical entity; syndrome

Disease Type

disease

Hpo Class Name

Abnormality of the digestive systemAbnormality of the integument

Do Disease Class

disease of anatomical entitydisease of anatomical entity; syndrome

Hpo Disease Class

Abnormality of the digestive systemAbnormality of the integument

Umls Disease Type

Disease or Syndrome

Basic Information

Disease Name

Biliary Cirrhosis, Primary, 1

Global Category

Genetic diseases;Rare diseases

Anatomical Category

Endocrine diseases;Gastrointestinal Diseases;Immune diseases;Liver diseases

Disease Name

Localized Scleroderma

Global Category

Genetic diseases;Rare diseases

Anatomical Category

Bone diseases;Immune diseases;Nephrological diseases;Neuronal diseases;Respiratory diseases;Skin diseases

Disease Definition

HPO2016_07_04:Isolated patches of hardened skin (scleroderma). [HPO:probinson]NCI2016_02D:An autoimmune inflammatory disorder characterized by destruction of the small intrahepatic bile ducts. It affects predominantly females and it may lead to cirrhosis and liver failure. Patients have antimitochondrial and antinuclear antibodies in the peripheral blood.|CSP2006:a form of biliary cirrhosis in which small intrahepatic ducts are destroyed while the major intra and extra hepatic ducts remain patent; most patients are middle aged females and have circulating antimitochondrial antibodies.NCI2016_02D:Cirrhosis of the liver caused either by destruction of the intrahepatic bile ducts (primary biliary cirrhosis) or blockage of the extrahepatic bile ducts (secondary biliary cirrhosis).|MSH2017_2016_08_12:FIBROSIS of the hepatic parenchyma due to obstruction of BILE flow (CHOLESTASIS) in the intrahepatic or extrahepatic bile ducts (BILE DUCTS, INTRAHEPATIC; BILE DUCTS, EXTRAHEPATIC). Primary biliary cirrhosis involves the destruction of small intra-hepatic bile ducts and bile secretion. Secondary biliary cirrhosis is produced by prolonged obstruction of large intrahepatic or extrahepatic bile ducts from a variety of causes.|HPO2016_07_04:Progressive destruction of the small-to-medium bile ducts of the intrahepatic biliary tree, which leads to progressive cholestasis and often end-stage liver disease. [HPO:probinson]NCI2016_NICHD_1602D:A chronic and progressive autoimmune disorder characterized by thickening of the skin and the connective tissues.|NCI2016_NCI-GLOSS_1602D:A chronic disorder marked by hardening and thickening of the skin. Scleroderma can be localized or it can affect the entire body (systemic).|NCI2016_02D:A localized or systemic chronic and progressive autoimmune disorder characterized by thickening of the skin and the connective tissues. Localized scleroderma affects only the skin. Systemic scleroderma affects internal organs, including the heart, lungs, gastrointestinal tract, and kidneys.|MEDLINEPLUS_20151021:Scleroderma means hard skin. It is a group of diseases that cause abnormal growth of connective tissue. Connective tissue is the material inside your body that gives your tissues their shape and helps keep them strong. In scleroderma, the tissue gets hard or thick. It can cause swelling or pain in your muscles and joints. Symptoms of scleroderma include <ul> <li> Calcium deposits in connective tissues</li> <li> <a href='https://www.nlm.nih.gov/medlineplus/raynaudsdisease.html'>Raynaud's phenomenon</a>, a narrowing of blood vessels in the hands or feet</li> <li> Swelling of the esophagus, the tube between your throat and stomach</li> <li> Thick, tight skin on your fingers</li> <li> Red spots on your hands and face </li> </ul> No one knows what causes scleroderma. It is more common in women. It can be mild or severe. Doctors diagnose scleroderma using your medical history, a physical exam, lab tests, and a skin biopsy. There is no cure, but various treatments can control symptoms and complications. NIH: National Institute of Arthritis and Musculoskeletal and Skin Diseases|HPO2016_07_04:A chronic autoimmune phenomenon characterized by fibrosis (or hardening) and vascular alterations of the skin. [HPO:sdoelken]|CSP2006:chronic hardening and thickening of the skin caused by swelling and thickening of fibrous tissue leading to eventual atrophy of the epidermis; can occur as a localized or a systemic disease.|CHV2011_02:pathologic thickening or hardening of skin|CHV2011_02:pathologic thickening or hardening of skin|CHV2011_02:pathologic thickening or hardening of skinNCI2016_NICHD_1602D:A heterogeneous disorder characterized by small vessel vasculopathy, autoantibodies, and fibroblast dysfunction which results in hardening and thickening of body tissue. The clinical manifestations vary with the majority of the patients having skin thickening and involvement of internal organs.|NCI2016_NCI-GLOSS_1602D:A disease that is marked by hardening and thickening of skin, connective tissue that surrounds other tissues and organs, and blood vessels.|NCI2016_02D:A chronic disorder, possibly autoimmune, marked by excessive production of collagen which results in hardening and thickening of body tissues. The two types of systemic scleroderma, limited cutaneous and diffuse cutaneous are classified with focus on the extent of affected skin. A relationship exists between the extent of skin area affected and degree of internal organ/system involvement. Systemic scleroderma can manifest itself in pulmonary fibrosis, Raynaud's syndrome, digestive system telangiectasias, renal hypertension and/or pulmonary hypertension.|MSH2017_2016_08_12:A chronic multi-system disorder of CONNECTIVE TISSUE. It is characterized by SCLEROSIS in the SKIN, the LUNGS, the HEART, the GASTROINTESTINAL TRACT, the KIDNEYS, and the MUSCULOSKELETAL SYSTEM. Other important features include diseased small BLOOD VESSELS and AUTOANTIBODIES. The disorder is named for its most prominent feature (hard skin), and classified into subsets by the extent of skin thickening: LIMITED SCLERODERMA and DIFFUSE SCLERODERMA.|CSP2006:systemic disorder of the connective tissue; manifested by hardening and thickening of the skin, by abnormalities involving the microvasculature and larger vessels, and by fibrotic degenerative changes in various body organs including the heart, lungs, kidneys, and gastrointestinal tract.|CHV2011_02:a rare, chronic disease characterized by excessive deposits of collagen in the skin or other organs|CHV2011_02:a rare, chronic disease characterized by excessive deposits of collagen in the skin or other organs|CHV2011_02:a rare, chronic disease characterized by excessive deposits of collagen in the skin or other organs|CHV2011_02:a rare, chronic disease characterized by excessive deposits of collagen in the skin or other organs|CHV2011_02:a rare, chronic disease characterized by excessive deposits of collagen in the skin or other organsNCI2016_NICHD_1602D:A variant of systemic scleroderma characterized by features such as calcinosis, Raynaud phenomenon, esophageal motility disorders, sclerodactyly, and telangiectasia.|NCI2016_02D:A variant of systemic sclerosis characterized by calcinosis, Raynaud phenomenon, esophageal motility disorders, sclerodactyly, and telangiectasia.|MSH2017_2016_08_12:A mild form of LIMITED SCLERODERMA, a multi-system disorder. Its features include symptoms of CALCINOSIS; RAYNAUD DISEASE; ESOPHAGEAL MOTILITY DISORDERS; sclerodactyly, and TELANGIECTASIS. When the defect in esophageal function is not prominent, it is known as CRST syndrome.NCI2016_NICHD_1602D:An autoimmune disorder marked by excessive production of collagen resulting in hardening and thickening of skin, with formation of patches or lines of thick and unyielding tissue. There can also be musculoskeletal and underlying tissue involvement. The affected areas of skin can be restrictive and disfiguring.|NCI2016_02D:A chronic disorder, possibly autoimmune, marked by excessive production of collagen which results in hardening and thickening of body tissues. Localized scleroderma typically affects the skin, with formation of patches or lines of thick and unyielding tissue; there can be muscle and underlying tissue involvement as well as occasional joint complications. The affected areas of skin can be restrictive and disfiguring. The shape, depth and location of the affected area is used to classify one of the four types of local scleroderma. An individual can have a combination of localized scleroderma types.|MSH2017_2016_08_12:A term used to describe a variety of localized asymmetrical SKIN thickening that is similar to those of SYSTEMIC SCLERODERMA but without the disease features in the multiple internal organs and BLOOD VESSELS. Lesions may be characterized as patches or plaques (morphea), bands (linear), or nodules.Reynolds syndrome (RS) is an autoimmune disorder characterized by the association of primary biliary cirrhosis (PBC) with limited cutaneous systemic sclerosis (lcSSc) (see these terms).

Me Sh Disease Class

Cardiovascular Diseases; Digestive System Diseases; Skin and Connective Tissue Diseases; Nutritional and Metabolic DiseasesDigestive System Diseases; Pathological Conditions, Signs and SymptomsDigestive System Diseases; Skin and Connective Tissue Diseases; Pathological Conditions, Signs and SymptomsSkin and Connective Tissue Diseases

Dis Ge Net Disease Type

disease

Disease Class Name Me Sh

Digestive System Diseases; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases; Cardiovascular DiseasesPathological Conditions, Signs and Symptoms; Digestive System DiseasesPathological Conditions, Signs and Symptoms; Digestive System Diseases; Skin and Connective Tissue DiseasesSkin and Connective Tissue Diseases

Umls Semantic Type Name

Disease or Syndrome