ReferenceID 994
2'-Hydroxycinnamaldehyde ameliorates imiquimod-induced psoriasiform inflammation by targeting PKM2-STAT3 signaling in mice
Exp Mol Med
2'-Hydroxycinnamaldehyde (HCA), the active component isolated from the stem bark of Cinnamomum cassia, exerts anticancer effects through multiple mechanisms. We recently determined that HCA inhibits signal transducer and
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Record Fields
Scalar fields from the final reference record.
- Reference Id
- 994
- Evidence Id
- 17584
- Core Evidence Id
- 17584
- Source Reference Id
- 1991
- Herb2 Reference Id
- HBREF002788
- Subject Paper Key
- HBIN005791_33990689
- Pubmed Id
- 33990689
- Doi
- 10.1038/s12276-021-00620-z
- Paper Title
- 2'-Hydroxycinnamaldehyde ameliorates imiquimod-induced psoriasiform inflammation by targeting PKM2-STAT3 signaling in mice
- Paper Abstract
- 2'-Hydroxycinnamaldehyde (HCA), the active component isolated from the stem bark of Cinnamomum cassia, exerts anticancer effects through multiple mechanisms. We recently determined that HCA inhibits signal transducer and activator of transcription 3 (STAT3) signaling in prostate cancer cells. Because STAT3 overactivation has been closely associated with the development of psoriasis, a chronic autoimmune skin disease, we examined whether HCA ameliorates skin lesions in an imiquimod-induced psoriasis-like mouse model. The results showed that intraperitoneal administration of HCA alleviated imiquimod-induced psoriasis-like dermatitis, epidermal thickening, dermal infiltration of inflammatory cells, and proinflammatory cytokine production. Mechanistically, HCA inhibited pyruvate kinase isozyme M2 and STAT3 signaling, leading to the suppression of T cell activation, Th17 cell differentiation, and keratinocyte hyperproliferation. These results suggest that HCA may be a new treatment for psoriasis and other STAT3-mediated skin disorders, such as infection, inflammation and carcinogenesis.
- Journal
- Exp Mol Med
- Publish Year
- 2021
- Experiment Subject
- mouse
- Experiment Type
- Animal & Cell Experiment
- Phenotype Related
- Prostate Cancer; Stat3-mediated Skin Disorders; Psoriasis; Inflammation; Epidermal Thickening; Keratinocyte Hyperproliferation; Dermatitis; Chronic Autoimmune Skin Disease
- Paper Title Cn
- Paper Title En
- 2'-Hydroxycinnamaldehyde ameliorates imiquimod-induced psoriasiform inflammation by targeting PKM2-STAT3 signaling in mice
- Bilingual Status
- semi_complete