ReferenceID 971
Cimicifuga racemosa Extract Ze 450 Re-Balances Energy Metabolism and Promotes Longevity
Antioxidants (Basel)
Recently, we reported that the Cimicifuga racemosa extract Ze 450 mediated protection from oxidative cell damage through a metabolic shift from oxidative phosphorylation to glycolysis. Here, we investigated the molecular
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Record Fields
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- Reference Id
- 971
- Evidence Id
- 17561
- Core Evidence Id
- 17561
- Source Reference Id
- 1936
- Herb2 Reference Id
- HBREF002733
- Subject Paper Key
- HERB007253_34573064
- Pubmed Id
- 34573064
- Doi
- 10.3390/antiox10091432
- Paper Title
- Cimicifuga racemosa Extract Ze 450 Re-Balances Energy Metabolism and Promotes Longevity
- Paper Abstract
- Recently, we reported that the Cimicifuga racemosa extract Ze 450 mediated protection from oxidative cell damage through a metabolic shift from oxidative phosphorylation to glycolysis. Here, we investigated the molecular mechanisms underlying the effects of Ze 450 against ferroptosis in neuronal cells, with a particular focus on mitochondria. The effects of Ze 450 on respiratory complex activity and hallmarks of ferroptosis were studied in isolated mitochondria and in cultured neuronal cells, respectively. In addition, Caenorhabditis elegans served as a model organism to study mitochondrial damage and longevity in vivo. We found that Ze 450 directly inhibited complex I activity in mitochondria and enhanced the metabolic shift towards glycolysis via cMyc and HIF1alpha regulation. The protective effects against ferroptosis were mediated independently of estrogen receptor activation and were distinct from effects exerted by metformin. In vivo, Ze 450 protected C. elegans from the mitochondrial toxin paraquat and promoted longevity in a dose-dependent manner. In conclusion, Ze 450 mediated a metabolic shift to glycolysis via direct effects on mitochondria and altered cell signaling, thereby promoting sustained cellular resilience to oxidative stress in vitro and in vivo.
- Journal
- Antioxidants (Basel)
- Publish Year
- 2021
- Experiment Subject
- cultured neuronal cells
- Experiment Type
- Animal Experiment
- Phenotype Related
- Ferroptosis
- Paper Title Cn
- Paper Title En
- Cimicifuga racemosa Extract Ze 450 Re-Balances Energy Metabolism and Promotes Longevity
- Bilingual Status
- semi_complete