ReferenceID 944
The Effects of Nettle Extract Consumption on Liver PPARs, SIRT1, ACOX1 and Blood Lipid Levels in Male and Female C57Bl6 Mice
Nutrients
The aim of this study was to evaluate how nettle ( Urtica dioica L.) water extract consumption would interact with regulators of peroxysomal lipid oxidation, histone deacetylase, and markers of oxidative stress in the li
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Record Fields
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- Reference Id
- 944
- Evidence Id
- 17534
- Core Evidence Id
- 17534
- Source Reference Id
- 1886
- Herb2 Reference Id
- HBREF002683
- Subject Paper Key
- HERB006575_36364732
- Pubmed Id
- 36364732
- Doi
- 10.3390/nu14214469
- Paper Title
- The Effects of Nettle Extract Consumption on Liver PPARs, SIRT1, ACOX1 and Blood Lipid Levels in Male and Female C57Bl6 Mice
- Paper Abstract
- The aim of this study was to evaluate how nettle ( Urtica dioica L.) water extract consumption would interact with regulators of peroxysomal lipid oxidation, histone deacetylase, and markers of oxidative stress in the liver and blood lipid levels in male and female C57Bl6 mice. Metabolically unchallenged (healthy) mice ( n = 5 per sex) were treated with a nettle extract in a dose of 40 mg of total polyphenols in the extract per kg mice body weight. The nettle extract was applied daily along with normal diet for 15 days. The serum triglycerides, cholesterol, HDL, LDL, and liver PPAR-α, PPAR-γ, PGC-1-α, ACOX1, SIRT1, MDA, SOD, CAT, and GSH were compared between exposed and unexposed (control) animals. In males, the PPAR-α, PGC1-α, and ACOX1 levels together with systemic HDL cholesterol were significantly ( p ≤ 0.05) increased while the LDL cholesterol decreased ( p ≤ 0.05). In females, no changes in PPAR-α and PGC1-α or serum lipids were noted, but the ACOX1 content in the liver was significantly ( p ≤ 0.05) increased. The SIRT1 activity increased ( p ≤ 0.05) only in females. In both sexes, the PPAR-γ levels were not significantly ( p ≤ 0.05) affected in either sex. The results indicate that nettle plant extract has the potential to modulate selected transcriptional factors and histone deacetylase in vivo, with certain sex differences, which should be studied further in similar models.
- Journal
- Nutrients
- Publish Year
- 2022
- Experiment Subject
- mouse
- Experiment Type
- Animal Experiment
- Phenotype Related
- Paper Title Cn
- Paper Title En
- The Effects of Nettle Extract Consumption on Liver PPARs, SIRT1, ACOX1 and Blood Lipid Levels in Male and Female C57Bl6 Mice
- Bilingual Status
- semi_complete