ReferenceID 921
Paramylon from Euglena gracilis Prevents Lipopolysaccharide-Induced Acute Liver Injury
Front Immunol
Acute liver injury (ALI) is a life-threatening syndrome with high mortality and lacks effective therapies. Rodents under LPS (lipopolysaccharide)/D-Gal (D-galactosamine) stress mimic ALI by presenting dramatically increa
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- Reference Id
- 921
- Evidence Id
- 17511
- Core Evidence Id
- 17511
- Source Reference Id
- 1828
- Herb2 Reference Id
- HBREF002625
- Subject Paper Key
- HERB005893_35126359
- Pubmed Id
- 35126359
- Doi
- 10.3389/fimmu.2021.797096
- Paper Title
- Paramylon from Euglena gracilis Prevents Lipopolysaccharide-Induced Acute Liver Injury
- Paper Abstract
- Acute liver injury (ALI) is a life-threatening syndrome with high mortality and lacks effective therapies. Rodents under LPS (lipopolysaccharide)/D-Gal (D-galactosamine) stress mimic ALI by presenting dramatically increased inflammation and cell death in the liver. Euglena gracilis, functioning like dietary fiber, is commonly used as a paramylon (Pa)-rich nutritional supplement that has various biological effects such as regulating immune system, anti-obesity, and anti-tumor. Here, we found that Pa or sonicated and alkalized paramylon (SA-Pa) alleviated the LPS/D-Gal-induced hepatic histopathological abnormalities in mice. Compared with Pa, SA-Pa had lower molecular weights/sizes and showed better efficacy in alleviating injury-induced hepatic functions, as well as the transcriptional levels of inflammatory cytokines. Moreover, SA-Pa treatment promoted M2 macrophage activation that enhanced the anti-inflammatory function in the liver, and downregulated STAT3 target genes, such as Fos, Jun, and Socs3 upon the injury. Meanwhile, SA-Pa treatment also alleviated apoptosis and necroptosis caused by the injury. Our results demonstrated that SA-Pa efficiently protected the liver from LPS/D-Gal-induced ALI by alleviating inflammation and cell death.
- Journal
- Front Immunol
- Publish Year
- 2022
- Experiment Subject
- mouse
- Experiment Type
- Animal Experiment
- Phenotype Related
- Acute Liver Injury; Inflammation
- Paper Title Cn
- Paper Title En
- Paramylon from Euglena gracilis Prevents Lipopolysaccharide-Induced Acute Liver Injury
- Bilingual Status
- semi_complete