ReferenceID 918
Cinnamon extract inhibits allergen-specific immune responses in human and murine allergy models
Clin Exp Allergy
BACKGROUND: Ceylon cinnamon has been shown to possess anti-inflammatory properties in many diseases including allergic inflammation. OBJECTIVE: The aim of this study was to analyse in more detail the effects of cinnamon
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- Reference Id
- 918
- Evidence Id
- 17508
- Core Evidence Id
- 17508
- Source Reference Id
- 1823
- Herb2 Reference Id
- HBREF002620
- Subject Paper Key
- HERB005843_31573731
- Pubmed Id
- 31573731
- Doi
- 10.1111/cea.13507
- Paper Title
- Cinnamon extract inhibits allergen-specific immune responses in human and murine allergy models
- Paper Abstract
- BACKGROUND: Ceylon cinnamon has been shown to possess anti-inflammatory properties in many diseases including allergic inflammation. OBJECTIVE: The aim of this study was to analyse in more detail the effects of cinnamon extract (CE) and its major compounds p-cymene and trans-cinnamaldehyde (CA) on allergen-specific immune responses in vitro and in vivo. METHODS: Therefore, monocyte-derived mature dendritic cells (DC) from grass or birch pollen allergic donors were pulsed with the respective allergen in the presence or absence of CE, p-cymene, CA or the solvent ethanol and co-cultured with autologous CD4+ T cells. Furthermore, basophil activation test was performed with or without CE or ethanol treatment. For the in vivo experiments, BALB/c mice were immunized with ovalbumin (OVA) and orally treated with CE or ethanol. RESULTS: Addition of CE, p-cymene or CA, but not ethanol significantly inhibited DC maturation and subsequent allergen-specific T cell proliferation as well as Th1 and Th2 cytokine production. Sulphidoleukotriene release and CD63 expression by basophils were also significantly diminished after addition of CE. In vivo, treatment of OVA-sensitized mice with CE led to a significant shift from OVA-specific IgE towards IgG2a production and to a strong inhibition of OVA-specific proliferation. Moreover, airway inflammation as well as anaphylaxis after intranasal or systemic allergen challenge was significantly reduced in CE-treated mice. Furthermore, topical application of CE prevented calcipotriol-induced atopic dermatitis-like inflammation in these mice. CONCLUSIONS AND CLINICAL RELEVANCE: Taken together, our data indicate that the anti-inflammatory effect of cinnamon might be exploited for treatment of allergic inflammation, which needs to be further investigated.
- Journal
- Clin Exp Allergy
- Publish Year
- 2020
- Experiment Subject
- mouse
- Experiment Type
- Animal & Cell Experiment
- Phenotype Related
- Allergic Inflammation; Atopic Dermatitis-like Inflammation; Airway Inflammation; Anaphylaxis
- Paper Title Cn
- Paper Title En
- Cinnamon extract inhibits allergen-specific immune responses in human and murine allergy models
- Bilingual Status
- semi_complete