ReferenceID 888
Persimmon leaf extract protects mice from atopic dermatitis by inhibiting T cell activation via regulation of the JNK pathway
Phytother Res
Persimmon leaf extracts (PLE) have been widely used as a traditional medicine in East Asian countries. The effects of persimmon leaves, including antioxidant, antiinflammatory, hypotensive, and anti-allergy effects, have
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- Reference Id
- 888
- Evidence Id
- 17478
- Core Evidence Id
- 17478
- Source Reference Id
- 1766
- Herb2 Reference Id
- HBREF002563
- Subject Paper Key
- HERB005099_33401337
- Pubmed Id
- 33401337
- Doi
- 10.1002/ptr.6985
- Paper Title
- Persimmon leaf extract protects mice from atopic dermatitis by inhibiting T cell activation via regulation of the JNK pathway
- Paper Abstract
- Persimmon leaf extracts (PLE) have been widely used as a traditional medicine in East Asian countries. The effects of persimmon leaves, including antioxidant, antiinflammatory, hypotensive, and anti-allergy effects, have been investigated; however, there is little evidence on the inhibition of T cell activation in vitro and effects on T cell-related diseases, such as atopic dermatitis (AD), in vivo by persimmon leaves. PLE (50 mug/mL) effectively attenuated the mRNA levels of IL-2 in Jurkat T cells stimulated with PMA/A23187 and Staphylococcus enterotoxin E-loaded Raji B cells without causing cytotoxicity. In Jurkat T cells stimulated with PMA/A23187, treatment with 50 mug/mL PLE blocked the translocation of p65 and IkappaBalpha degradation. Moreover, the JNK signaling pathway in Jurkat T cells stimulated with PMA/A23187 was affected by treatment with PLE. The oral administration of PLE markedly attenuated AD manifestations in mice, including ear thickness, IgE levels, and lymph node sizes. These results indicate PLE significantly blocked T cell activation via NF-kappaB signaling and the JNK pathway. This suggests underlying mechanisms of PLE involving the control of effector cytokines produced by activated T cells in ear tissue and lymph nodes, as well as the infiltration of mast cells and the therapeutic potential of AD.
- Journal
- Phytother Res
- Publish Year
- 2021
- Experiment Subject
- mouse; jurkat t cells; staphylococcus enterotoxin e-loaded raji b cells
- Experiment Type
- Animal & Cell Experiment
- Phenotype Related
- Atopic Dermatitis
- Paper Title Cn
- Paper Title En
- Persimmon leaf extract protects mice from atopic dermatitis by inhibiting T cell activation via regulation of the JNK pathway
- Bilingual Status
- semi_complete