ReferenceID 880
Thymus vulgaris Essential Oil Protects Zebrafish against Cognitive Dysfunction by Regulating Cholinergic and Antioxidants Systems
Antioxidants (Basel)
Thymus vulgaris L. is an aromatic herb used for medicinal purposes such as antimicrobial, spasmolytic, antioxidant, anti-inflammatory, antinociceptive, antitumor, and may have beneficial effects in the treatment of Alzhe
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Record Fields
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- Reference Id
- 880
- Evidence Id
- 17470
- Core Evidence Id
- 17470
- Source Reference Id
- 1749
- Herb2 Reference Id
- HBREF002546
- Subject Paper Key
- HERB004986_33158153
- Pubmed Id
- 33158153
- Doi
- 10.3390/antiox9111083
- Paper Title
- Thymus vulgaris Essential Oil Protects Zebrafish against Cognitive Dysfunction by Regulating Cholinergic and Antioxidants Systems
- Paper Abstract
- Thymus vulgaris L. is an aromatic herb used for medicinal purposes such as antimicrobial, spasmolytic, antioxidant, anti-inflammatory, antinociceptive, antitumor, and may have beneficial effects in the treatment of Alzheimer's disease. The present study aimed to investigate whether Thymus vulgaris L. essential oil enhances cognitive function via the action on cholinergic neurons using scopolamine (Sco)-induced zebrafish (Danio rerio) model of memory impairments. Thymus vulgaris L. essential oil (TEO, 25, 150, and 300 microL/L) was administered by immersion to zebrafish once daily for 13 days, whereas memory impairment was induced by Sco (100 muM), a muscarinic receptor antagonist, delivered 30 min before behavioral tests. Spatial memory was assessed using the Y-maze test and novel object recognition test (NOR). Anxiety and depression were measured in the novel tank diving test (NTT). Gas Chromatograph-Mass Spectrometry (GC-MS) analysis was used to study the phytochemical composition of TEO. Acetylcholinesterase (AChE) activity and oxidative stress response in the brain of zebrafish were determined. TEO ameliorated Sco-induced increasing of AChE activity, amnesia, anxiety, and reduced the brain antioxidant capacity. These results suggest that TEO may have preventive and/or therapeutic potentials in the management of memory deficits and brain oxidative stress in zebrafish with amnesia.
- Journal
- Antioxidants (Basel)
- Publish Year
- 2020
- Experiment Subject
- zebrafish
- Experiment Type
- Animal Experiment
- Phenotype Related
- Alzheimer's Disease; Memory Deficits; Anxiety; Brain Oxidative Stress; Memory Impairments; Amnesia
- Paper Title Cn
- Paper Title En
- Thymus vulgaris Essential Oil Protects Zebrafish against Cognitive Dysfunction by Regulating Cholinergic and Antioxidants Systems
- Bilingual Status
- semi_complete