ReferenceID 88
Preventive and therapeutic effects of oleuropein against carbon tetrachloride-induced liver damage in mice
Pharmacol Res
Olives and olive products, an inevitable part of the Mediterranean diet, possess various beneficial effects, such as a decreased risk of cardiovascular disease and cancer. Oleuropein is a non-toxic secoiridoid found in
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Record Fields
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- Reference Id
- 88
- Evidence Id
- 16678
- Core Evidence Id
- 16678
- Source Reference Id
- 150
- Herb2 Reference Id
- HBREF000323
- Subject Paper Key
- HBIN038054_22214867
- Pubmed Id
- 22214867
- Doi
- 10.1016/j.phrs.2011.12.005
- Paper Title
- Preventive and therapeutic effects of oleuropein against carbon tetrachloride-induced liver damage in mice
- Paper Abstract
- Olives and olive products, an inevitable part of the Mediterranean diet, possess various beneficial effects, such as a decreased risk of cardiovascular disease and cancer. Oleuropein is a non-toxic secoiridoid found in the leaves and fruits of olive (Olea europaea L.). In this study, we have investigated the hepatoprotective activity of oleuropein in carbon tetrachloride (CCl(4))-induced liver injury in male BALB/cN mice. Oleuropein in doses of 100 and 200mg/kg was administered intraperitoneally (ip) once daily for 3 consecutive days, prior to CCl(4) administration (the preventive treatment), or once daily for 2 consecutive days 6h after CCl(4) intoxication (the curative treatment). CCl(4) intoxication resulted in a massive hepatic necrosis and increased plasma transaminases. Liver injury was associated with oxidative/nitrosative stress evidenced by increased nitrotyrosine formation as well as a significant decrease in superoxide dismutase activity and glutathione levels. CCl(4) administration triggered inflammatory response in mice livers by inducing expression of nuclear factor-kappaB, which coincided with the induction of tumor necrosis factor-alpha, cyclooxygenase-2 and inducible nitric oxide synthase. In both treatment protocols, oleuropein significantly attenuated oxidative/nitrosative stress and inflammatory response and improved histological and plasma markers of liver damage. Additionally, in the curative regimen, oleuropein prevented tumor necrosis factor-beta1-mediated activation of hepatic stellate cells, as well as the activation of caspase-3. The hepatoprotective activity of oleuropein was, at least in part, achieved through the NF-E2-related factor 2-mediated induction of heme oxygenase-1. The present study demonstrates antioxidant, anti-inflammatory, antiapoptotic, and antifibrotic activity of oleuropein, with more pronounced therapeutic than prophylactic effects.
- Journal
- Pharmacol Res
- Publish Year
- 2012
- Experiment Subject
- mouse
- Experiment Type
- Animal Experiment
- Phenotype Related
- Liver Damage
- Paper Title Cn
- Paper Title En
- Preventive and therapeutic effects of oleuropein against carbon tetrachloride-induced liver damage in mice
- Bilingual Status
- semi_complete