ReferenceID 865
Morus alba Root Extract Induces the Anagen Phase in the Human Hair Follicle Dermal Papilla Cells
Pharmaceutics
Restoring hair follicles by inducing the anagen phase is a promising approach to prevent hair loss. Hair follicle dermal papilla cells (HFDPCs) play a major role in hair growth via the telogen-to-anagen transition. The t
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Record Fields
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- Reference Id
- 865
- Evidence Id
- 17455
- Core Evidence Id
- 17455
- Source Reference Id
- 1730
- Herb2 Reference Id
- HBREF002527
- Subject Paper Key
- HERB004833_34452116
- Pubmed Id
- 34452116
- Doi
- 10.3390/pharmaceutics13081155
- Paper Title
- Morus alba Root Extract Induces the Anagen Phase in the Human Hair Follicle Dermal Papilla Cells
- Paper Abstract
- Restoring hair follicles by inducing the anagen phase is a promising approach to prevent hair loss. Hair follicle dermal papilla cells (HFDPCs) play a major role in hair growth via the telogen-to-anagen transition. The therapeutic effect of Morus alba activates beta-catenin in HFDPCs, thereby inducing the anagen phase. The HFDPCs were treated with M. alba root extract (MARE) to promote hair growth. It contains chlorogenic acid and umbelliferone and is not cytotoxic to HFDPCs at a concentration of 20%. It was demonstrated that a small amount of MARE enhances growth factor secretion (related to the telogen-to-anagen transition). Activation of beta-catenin was observed in MARE-treated HFDPCs, which is crucial for inducing the anagen phase. The effect of conditioned medium derived from MARE-treated HFDPCs on keratinocytes and endothelial cells was also investigated. The findings of this study demonstrate the potency of MARE in eliciting the telogen-to-anagen transition.
- Journal
- Pharmaceutics
- Publish Year
- 2021
- Experiment Subject
- mare-treated hfdpcs
- Experiment Type
- Cell Experiment
- Phenotype Related
- Paper Title Cn
- Paper Title En
- Morus alba Root Extract Induces the Anagen Phase in the Human Hair Follicle Dermal Papilla Cells
- Bilingual Status
- semi_complete