ReferenceID 826
Spatholobus suberectus Dunn Water Extract Ameliorates Atopic Dermatitis-Like Symptoms by Suppressing Proinflammatory Chemokine Production In Vivo and In Vitro
Front Pharmacol
S. patholobus suberectus Dunn, a traditional Chinese herbal medicine, has various pharmacological activities, such as anti-inflammatory properties. However, to the best of our knowledge, its therapeutic effect on atopic
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Record Fields
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- Reference Id
- 826
- Evidence Id
- 17416
- Core Evidence Id
- 17416
- Source Reference Id
- 1642
- Herb2 Reference Id
- HBREF002439
- Subject Paper Key
- HERB003927_35795574
- Pubmed Id
- 35795574
- Doi
- 10.3389/fphar.2022.919230
- Paper Title
- Spatholobus suberectus Dunn Water Extract Ameliorates Atopic Dermatitis-Like Symptoms by Suppressing Proinflammatory Chemokine Production In Vivo and In Vitro
- Paper Abstract
- S. patholobus suberectus Dunn, a traditional Chinese herbal medicine, has various pharmacological activities, such as anti-inflammatory properties. However, to the best of our knowledge, its therapeutic effect on atopic dermatitis (AD) has not been investigated. In this study, we explored the effect of S. suberectus Dunn water extract (SSWex) on AD in vivo and in vitro . In Dermatophagoides farina extract (DfE)-treated NC/Nga mice, the oral administration of SSWex alleviated AD-like symptoms, such as ear thickness, dermatitis score, epidermal thickness, immune cell infiltration, and levels of AD-related serum parameters (immunoglobulin E, histamine, and proinflammatory chemokines). In HaCaT cells, the production of proinflammatory chemokines induced by interferon-γ (IFN-γ) and tumor necrosis factor-α (TNF-α) was inhibited by SSWex pretreatment. SSWex treatment inhibited the phosphorylation of mitogen-activated protein kinase and activation and translocation of transcriptional factors, such as signal transducer and activator of transcription 1 and nuclear factor kappa B in IFN-γ/TNF-α-stimulated HaCaT cells. These results indicate that SSWex may be developed as an efficient therapeutic agent for AD.
- Journal
- Front Pharmacol
- Publish Year
- 2022
- Experiment Subject
- mouse; hacat cells; ifn-γ/tnf-α-stimulated hacat cells
- Experiment Type
- Animal & Cell Experiment
- Phenotype Related
- Atopic Dermatitis; Dermatitis; Tumor
- Paper Title Cn
- Paper Title En
- Spatholobus suberectus Dunn Water Extract Ameliorates Atopic Dermatitis-Like Symptoms by Suppressing Proinflammatory Chemokine Production In Vivo and In Vitro
- Bilingual Status
- semi_complete