ReferenceID 819
Attenuating Effects of Dieckol on Hypertensive Nephropathy in Spontaneously Hypertensive Rats
Int J Mol Sci
Hypertension induces renal fibrosis or tubular interstitial fibrosis, which eventually results in end-stage renal disease. Epithelial-to-mesenchymal transition (EMT) is one of the underlying mechanisms of renal fibrosis.
Relationship Network
Interactive first-hop connections across herbs, ingredients, formulas, targets, diseases, symptoms, syndromes, evidence, and monographs.
Click a node to open it in a new tab
Ingredient: 1Reference: 1Links: 1
Arranging relationship network...
Record Fields
Scalar fields from the final reference record.
- Reference Id
- 819
- Evidence Id
- 17409
- Core Evidence Id
- 17409
- Source Reference Id
- 3516
- Herb2 Reference Id
- HBREF004313
- Subject Paper Key
- HBIN023738_33921823
- Pubmed Id
- 33921823
- Doi
- 10.3390/ijms22084230
- Paper Title
- Attenuating Effects of Dieckol on Hypertensive Nephropathy in Spontaneously Hypertensive Rats
- Paper Abstract
- Hypertension induces renal fibrosis or tubular interstitial fibrosis, which eventually results in end-stage renal disease. Epithelial-to-mesenchymal transition (EMT) is one of the underlying mechanisms of renal fibrosis. Though previous studies showed that Ecklonia cava extracts (ECE) and dieckol (DK) had inhibitory action on angiotensin (Ang) I-converting enzyme, which converts Ang I to Ang II. It is known that Ang II is involved in renal fibrosis; however, it was not evaluated whether ECE or DK attenuated hypertensive nephropathy by decreasing EMT. In this study, the effect of ECE and DK on decreasing Ang II and its down signal pathway of angiotensin type 1 receptor (AT1R)/TGFbeta/SMAD, which is related with the EMT and restoring renal function in spontaneously hypertensive rats (SHRs), was investigated. Either ECE or DK significantly decreased the serum level of Ang II in the SHRs. Moreover, the renal expression of AT1R/TGFbeta/SMAD was decreased by the administration of either ECE or DK. The mesenchymal cell markers in the kidney of SHRs was significantly decreased by ECE or DK. The fibrotic tissue of the kidney of SHRs was also significantly decreased by ECE or DK. The ratio of urine albumin/creatinine of SHRs was significantly decreased by ECE or DK. Overall, the results of this study indicate that ECE and DK decreased the serum levels of Ang II and expression of AT1R/TGFbeta/SMAD, and then decreased the EMT and renal fibrosis in SHRs. Furthermore, the decrease in EMT and renal fibrosis could lead to the restoration of renal function. It seems that ECE or DK could be beneficial for decreasing hypertensive nephropathy by decreasing EMT and renal fibrosis.
- Journal
- Int J Mol Sci
- Publish Year
- 2021
- Experiment Subject
- rat
- Experiment Type
- Animal Experiment
- Phenotype Related
- Hypertension; End-stage Renal Disease; Renal Fibrosis; Hypertensive Nephropathy; Tubular Interstitial Fibrosis
- Paper Title Cn
- Paper Title En
- Attenuating Effects of Dieckol on Hypertensive Nephropathy in Spontaneously Hypertensive Rats
- Bilingual Status
- semi_complete