ReferenceID 809
Green tea extract exhibits antidiabetic effects partly through regulating dipeptidyl peptidase-4 expression in adipose tissue
J Nutr Biochem
The antidiabetic effects of green tea have been demonstrated in clinical trials and epidemiological studies. This study investigated the antidiabetic effects of green tea extract (GTE) and its underlying molecular mechan
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- Reference Id
- 809
- Evidence Id
- 17399
- Core Evidence Id
- 17399
- Source Reference Id
- 1610
- Herb2 Reference Id
- HBREF002407
- Subject Paper Key
- HERB003617_36228975
- Pubmed Id
- 36228975
- Doi
- 10.1016/j.jnutbio.2022.109173
- Paper Title
- Green tea extract exhibits antidiabetic effects partly through regulating dipeptidyl peptidase-4 expression in adipose tissue
- Paper Abstract
- The antidiabetic effects of green tea have been demonstrated in clinical trials and epidemiological studies. This study investigated the antidiabetic effects of green tea extract (GTE) and its underlying molecular mechanisms using a leptin receptor-deficient db/db mouse model (Lepr db/db ). Treatment with GTE for 2 weeks improved glucose tolerance and insulin sensitivity in Lepr db/db mice. In addition, GTE treatment reduced the body weight and adiposity of Lepr db/db mice. Furthermore, GTE treatment reduced pro-inflammatory gene expression, including nuclear factor kappa B (NF-κB) in white adipose tissue (WAT), and also reduced dipeptidyl peptidase-4 (DPP4) expression levels in WAT as well as in the serum. The promoter region of Dpp4 contains the NF-κB binding site, and DPP4 was found to be a direct target of NF-κB. Consistently, in vitro treatment of cells with GTE or its main constituent epigallocatechin gallate reduced lipopolysaccharide-induced NF-κB/DPP4 expression in 3T3-L1 adipocytes and RAW264.7 cells. Overall, our data demonstrated that GTE exerts an anti-diabetic effect by regulating the expression levels of NF-κB and DPP4 in WAT.
- Journal
- J Nutr Biochem
- Publish Year
- 2022
- Experiment Subject
- mouse; 3t3-l1 adipocytes; raw264.7 cells
- Experiment Type
- Animal & Cell Experiment
- Phenotype Related
- Paper Title Cn
- Paper Title En
- Green tea extract exhibits antidiabetic effects partly through regulating dipeptidyl peptidase-4 expression in adipose tissue
- Bilingual Status
- semi_complete