ReferenceID 798
Spirulina Enhances Bone Modeling in Growing Male Rats by Regulating Growth-Related Hormones
Nutrients
In recent years, growth hormone deficiency in children has been treated with hormone therapy despite the possible significant side effects. Therefore, it was deemed beneficial to develop functional foods or dietary suppl
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Record Fields
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- Reference Id
- 798
- Evidence Id
- 17388
- Core Evidence Id
- 17388
- Source Reference Id
- 1597
- Herb2 Reference Id
- HBREF002394
- Subject Paper Key
- HERB003610_32344533
- Pubmed Id
- 32344533
- Doi
- 10.3390/nu12041187
- Paper Title
- Spirulina Enhances Bone Modeling in Growing Male Rats by Regulating Growth-Related Hormones
- Paper Abstract
- In recent years, growth hormone deficiency in children has been treated with hormone therapy despite the possible significant side effects. Therefore, it was deemed beneficial to develop functional foods or dietary supplements for safely improving children's growth. Spirulina platensis is known for its high antioxidant, anti-aging, anti-cancer, and immunity-enhancing properties, as well as its high digestibility and high protein content, but little has been reported about its influence on bone development in children with a normal supply of protein. In this study, we evaluated the effects of spirulina on the bone metabolism and antioxidant profiles of three-week-old growing male rats. The animals were divided into four groups (n = 17 per group) and were fed AIN93G diets with 0% (control), 30% (SP30), 50% (SP50), and 70% (SP70) of casein protein replaced by spirulina, respectively, for seven weeks. We observed that spirulina enhanced bone growth and bone strength by stimulating parathyroid hormone and growth hormone activities, as well its increased antioxidant activity. These results indicate that spirulina provides a suitable dietary supplement and alternative protein source with antioxidant benefits for growth improvement in early developmental stages.
- Journal
- Nutrients
- Publish Year
- 2020
- Experiment Subject
- rat; children
- Experiment Type
- Animal Experiment
- Phenotype Related
- Growth Hormone Deficiency
- Paper Title Cn
- Paper Title En
- Spirulina Enhances Bone Modeling in Growing Male Rats by Regulating Growth-Related Hormones
- Bilingual Status
- semi_complete