ReferenceID 783
Betel leaf extract and its major component hydroxychavicol promote osteogenesis and alleviate glucocorticoid-induced osteoporosis in rats
Food Funct
Piper betle leaves possess several ethnomedicinal properties and are immensely used in traditional medicinal practices in regions of Asian and African subcontinents. However, their effects in treating skeletal complicati
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Record Fields
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- Reference Id
- 783
- Evidence Id
- 17373
- Core Evidence Id
- 17373
- Source Reference Id
- 1554
- Herb2 Reference Id
- HBREF002351
- Subject Paper Key
- HERB003038_34105538
- Pubmed Id
- 34105538
- Doi
- 10.1039/d0fo02619k
- Paper Title
- Betel leaf extract and its major component hydroxychavicol promote osteogenesis and alleviate glucocorticoid-induced osteoporosis in rats
- Paper Abstract
- Piper betle leaves possess several ethnomedicinal properties and are immensely used in traditional medicinal practices in regions of Asian and African subcontinents. However, their effects in treating skeletal complications are least known. In this study, we evaluated cellular and molecular effects of betel leaf extract (BLE) and its major phytoconstituent, hydroxychavicol (HCV) in promoting osteogenesis in vitro and alleviating glucocorticoid induced osteoporosis (GIO) in vivo. Both BLE and HCV markedly stimulated osteoblast differentiation of C3H10T1/2 cells with increased expression of RUNX2 and osteopontin through the GSK-3beta/beta-catenin-signaling pathway. Also, oral administration of BLE and HCV in GIO rats resulted in restoration of bone mass and tissue microarchitecture. Thus, with our findings we conclude that BLE and HCV promote osteogenesis of C3H10T1/2 cells via the GSK-3beta/beta-catenin pathway and alleviate GIO in rats.
- Journal
- Food Funct
- Publish Year
- 2021
- Experiment Subject
- rat; c3h10t1/2 cells
- Experiment Type
- Animal Experiment
- Phenotype Related
- Osteogenesis; Osteoporosis
- Paper Title Cn
- Paper Title En
- Betel leaf extract and its major component hydroxychavicol promote osteogenesis and alleviate glucocorticoid-induced osteoporosis in rats
- Bilingual Status
- semi_complete