ReferenceID 774
Suppressive Effects of Turmeric Extract on Muscle Atrophy in Dexamethasone-Treated Mice and Myotubes
Nutrients
Sarcopenia is the decline in skeletal muscle mass, strength, and functions, which decreases the quality of life in elderly people. This study investigated the suppressive effect of turmeric (Curcuma longa) extract (TE) o
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Record Fields
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- Reference Id
- 774
- Evidence Id
- 17364
- Core Evidence Id
- 17364
- Source Reference Id
- 1539
- Herb2 Reference Id
- HBREF002336
- Subject Paper Key
- HERB002840_36235632
- Pubmed Id
- 36235632
- Doi
- 10.3390/nu14193979
- Paper Title
- Suppressive Effects of Turmeric Extract on Muscle Atrophy in Dexamethasone-Treated Mice and Myotubes
- Paper Abstract
- Sarcopenia is the decline in skeletal muscle mass, strength, and functions, which decreases the quality of life in elderly people. This study investigated the suppressive effect of turmeric (Curcuma longa) extract (TE) on muscle atrophy in dexamethasone (DEX)-treated mice and C2C12 myotubes. DEX treatment significantly decreased the muscle weight and significantly increased Fbxo32 and Murf1 expression in mice, and these changes were suppressed by the supplementation of an AIN-93 based diet with 2% TE. A similar pattern was observed in FBXO32 and MuRF1 protein expression. In C2C12 myotubes, DEX treatment significantly increased FBXO32 and MuRF1 gene and protein expression, and these increases were significantly suppressed by TE supplementation at a concentration of 200 µg/mL. Furthermore, one of the five TE fractions, which were separated by high-performance liquid chromatography had a similar effect with TE supplementation. The present study proposes the suppressive effect of turmeric on sarcopenia.
- Journal
- Nutrients
- Publish Year
- 2022
- Experiment Subject
- mouse; c2c12 myotubes; people
- Experiment Type
- Animal Experiment
- Phenotype Related
- Sarcopenia; Muscle Atrophy
- Paper Title Cn
- Paper Title En
- Suppressive Effects of Turmeric Extract on Muscle Atrophy in Dexamethasone-Treated Mice and Myotubes
- Bilingual Status
- semi_complete