ReferenceID 739
Safflower leaf ameliorates cognitive impairment through moderating excessive astrocyte activation in APP/PS1 mice
Food Funct
In addition to beta-amyloid (Abeta) plaques and neurofibrillary tangles, Alzheimer's disease (AD) is typically triggered or accompanied by abnormal inflammation, oxidative stress and astrocyte activation. Safflower (Cart
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Record Fields
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- Reference Id
- 739
- Evidence Id
- 17329
- Core Evidence Id
- 17329
- Source Reference Id
- 1460
- Herb2 Reference Id
- HBREF002257
- Subject Paper Key
- HERB002276_34730571
- Pubmed Id
- 34730571
- Doi
- 10.1039/d1fo01755a
- Paper Title
- Safflower leaf ameliorates cognitive impairment through moderating excessive astrocyte activation in APP/PS1 mice
- Paper Abstract
- In addition to beta-amyloid (Abeta) plaques and neurofibrillary tangles, Alzheimer's disease (AD) is typically triggered or accompanied by abnormal inflammation, oxidative stress and astrocyte activation. Safflower (Carthamus tinctorius L.) leaf, featuring functional ingredients, is a commonly consumed leafy vegetable. Whether and how dietary safflower leaf powder (SLP) ameliorates cognitive function in an AD mouse model has remained minimally explored. Therefore, we orally administered SLP to APP/PS1 transgenic mice to explore the neuroprotective effects of SLP in preventing AD progression. We found that SLP markedly improved cognitive impairment in APP/PS1 mice, as indicated by the water maze test. We further demonstrated that SLP treatment ameliorated inflammation, oxidative stress and excessive astrocyte activation. Further investigation indicated that SLP decreased the Abeta burden in APP/PS1 mice by mediating excessive astrocyte activation. Our study suggests that safflower leaf is possibly a promising, cognitively beneficial food for preventing and alleviating AD-related dementia.
- Journal
- Food Funct
- Publish Year
- 2021
- Experiment Subject
- mouse
- Experiment Type
- Animal Experiment
- Phenotype Related
- Ad-related Dementia; Neurofibrillary Tangles; Alzheimer's Disease
- Paper Title Cn
- Paper Title En
- Safflower leaf ameliorates cognitive impairment through moderating excessive astrocyte activation in APP/PS1 mice
- Bilingual Status
- semi_complete