ReferenceID 736
Hypericum ascyron L. extract reduces particulate matter-induced airway inflammation in mice
Phytother Res
The consequences of increased industrialization increased the risk of asthma and breathing difficulties due to increased particulate matter in the air. We aim to investigate the therapeutic properties of Hypericum ascyro
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Record Fields
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- Reference Id
- 736
- Evidence Id
- 17326
- Core Evidence Id
- 17326
- Source Reference Id
- 1457
- Herb2 Reference Id
- HBREF002254
- Subject Paper Key
- HERB002275_33150724
- Pubmed Id
- 33150724
- Doi
- 10.1002/ptr.6929
- Paper Title
- Hypericum ascyron L. extract reduces particulate matter-induced airway inflammation in mice
- Paper Abstract
- The consequences of increased industrialization increased the risk of asthma and breathing difficulties due to increased particulate matter in the air. We aim to investigate the therapeutic properties of Hypericum ascyron L. extract (HAE) in airway inflammation and unravel its mechanism of action. We conducted nitric oxide and cell viability assay, real-time PCR and western blot analyses along with in vitro studies. in vivo studies include a model of coal fly ash and diesel exhaust particle (CFD)-induced airway inflammation in mice. HAE reduced coal fly ash (CFA)-induced nitric oxide secretion without exhibiting cytotoxicity in MH-S cells. HAE also reduced the mRNA expression of pro-inflammatory cytokines and reduced the expression of proteins in the NFkappaB and MAPK pathways. In a mice model of CFD-induced airway inflammation, HAE effectively reduced neutrophil infiltration in bronchoalveolar lavage fluid (BALF) and increased the amount of T cells in the BALF, lungs, and blood while reducing all other immune cell subtypes to reduce airway inflammatory response. CXCL-1, IL-17, MIP-2, and TNF-alpha expression in the BALF were also reduced. HAE effectively reduced MIP-2 and TNF-alpha mRNA expression in the lung tissue of mice. In a nutshell, HAE is effective in preventing airway inflammation induced by CFA in MH-S cells, as well as inflammation induced by CFD in mice.
- Journal
- Phytother Res
- Publish Year
- 2021
- Experiment Subject
- mouse; mh-s cells
- Experiment Type
- Animal Experiment
- Phenotype Related
- Airway Inflammation; Asthma
- Paper Title Cn
- Paper Title En
- Hypericum ascyron L. extract reduces particulate matter-induced airway inflammation in mice
- Bilingual Status
- semi_complete