ReferenceID 725
Exploring the Potential Effects and Mechanisms of Asarum sieboldii Radix Essential Oil for Treatment of Asthma
Pharmaceutics
Asthma, a common chronic pulmonary disorder characterized by airway remodeling, hyperresponsiveness and obstruction, can be aggravated by repeated exposure to particulate matter (PM). The potential effect and mechanisms
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- Reference Id
- 725
- Evidence Id
- 17315
- Core Evidence Id
- 17315
- Source Reference Id
- 1442
- Herb2 Reference Id
- HBREF002239
- Subject Paper Key
- HERB002129_35335934
- Pubmed Id
- 35335934
- Doi
- 10.3390/pharmaceutics14030558
- Paper Title
- Exploring the Potential Effects and Mechanisms of Asarum sieboldii Radix Essential Oil for Treatment of Asthma
- Paper Abstract
- Asthma, a common chronic pulmonary disorder characterized by airway remodeling, hyperresponsiveness and obstruction, can be aggravated by repeated exposure to particulate matter (PM). The potential effect and mechanisms of Asarum sieboldii Radix essential oil (AEO) against asthma were explored based on network pharmacology. AEO was pre-treated using a nebulizer for 3 weeks and the mice were sensitized to ovalbumin (OVA) and PM 10 with the co-treatment of AEO for 4 weeks. In addition, A549 lung epithelial cells were sensitized with PM 10 to investigate the underlying mechanisms of AEO regarding the lung-fibrosis-related mediators. The target genes of methyl eugenol, a main compound of AEO, were highly matched by 48% with the gene set of asthma. AEO markedly inhibited the increase in epithelial thickness through the accumulation of goblet cells in the airways. Collagen deposition in the lung tissues of OVA+PM 10 -challenged asthmatic mice was significantly decreased by AEO. AEO also inhibited the influx of inflammatory cells in the bronchoalveolar lavage fluid, as well as the increases in serum IgE and IgG 2a and cytokines in the lung tissues. Furthermore, AEO regulated the expressions of fibrotic mediators, especially POSTN and TGF-β. In conclusion, we expect that AEO can be one of the effective alternative therapeutics to relieve asthma.
- Journal
- Pharmaceutics
- Publish Year
- 2022
- Experiment Subject
- mouse; a549 lung epithelial cells
- Experiment Type
- Animal Experiment
- Phenotype Related
- Chronic Pulmonary Disorder; Asthma; Airway Remodeling; Obstruction
- Paper Title Cn
- Paper Title En
- Exploring the Potential Effects and Mechanisms of Asarum sieboldii Radix Essential Oil for Treatment of Asthma
- Bilingual Status
- semi_complete